Experimental approaches have been applied to address questions in understanding three-dimensional chromatin organisation and function. As datasets increase in size and complexity, it becomes a challenge to reach a mechanistic interpretation of experimental results. Polymer simulations and mechanistic modelling have been applied to explain experimental observations, and the links to different aspects of genome function. Here, we provide a guide for biologists, explaining different simulation approaches and the contexts in which they have been used.
@article{arxiv.2010.06413,
title = {Mechanistic Modelling of Chromatin Folding to Understand Function},
author = {Chris A. Brackley and Davide Marenduzzo and Nick Gilbert},
journal= {arXiv preprint arXiv:2010.06413},
year = {2020}
}