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Ultrasound Localization Microscopy can resolve the microvascular bed down to a few micrometers. To achieve such performance microbubble contrast agents must perfuse the entire microvascular network. Microbubbles are then located…

Computer Vision and Pattern Recognition · Computer Science 2023-10-13 Léo Milecki , Jonathan Porée , Hatim Belgharbi , Chloé Bourquin , Rafat Damseh , Patrick Delafontaine-Martel , Frédéric Lesage , Maxime Gasse , Jean Provost

Ultrasound Localization Microscopy (ULM) relies on the injection of microbubbles (MBs) to obtain highly resolved density maps of blood circulation in vivo, with a resolution that can reach 10 {\mu}m ~ {\lambda}/10 in the rodent brain.…

Super-resolution ultrasound imaging through microbubble (MB) localisation and tracking, also known as ultrasound localisation microscopy, allows non-invasive sub-diffraction resolution imaging of microvasculature in animals and humans. The…

Image and Video Processing · Electrical Eng. & Systems 2025-05-23 Su Yan , Clotilde Vié , Marcelo Lerendegui , Herman Verinaz-Jadan , Jipeng Yan , Martina Tashkova , James Burn , Bingxue Wang , Gary Frost , Kevin G. Murphy , Meng-Xing Tang

Ultrasound contrast enhanced imaging has seen widespread uptake in research and clinical diagnostic imaging. This includes applications such as vector flow imaging, functional ultrasound and super-resolution Ultrasound Localization…

Image and Video Processing · Electrical Eng. & Systems 2022-11-03 Marcelo Lerendegui , Kai Riemer , Bingxue Wang , Christopher Dunsby , Meng-Xing Tang

Three-dimensional ultrasound localization microscopy (ULM) enables comprehensive visualization of the vasculature, thereby improving diagnostic reliability. Nevertheless, its clinical translation remains challenging, as the exponential…

Ultrasound vascular imaging is limited by acoustic diffraction, restricting visualization of microvessels essential for understanding organ function and disease. Label-free super-resolution methods exploiting endogenous red blood cells have…

In Ultrasound Localization Microscopy (ULM), achieving high-resolution images relies on the precise localization of contrast agent particles across a series of beamformed frames. However, our study uncovers an enormous potential: The…

Computational Geometry · Computer Science 2024-04-09 Christopher Hahne , Georges Chabouh , Arthur Chavignon , Olivier Couture , Raphael Sznitman

Generation of super-resolution (SR) ultrasound (US) images, created from the successive local-ization of individual microbubbles in the circulation, has enabled the visualization of microvascular structure and flow at a level of detail that…

Image and Video Processing · Electrical Eng. & Systems 2024-06-19 Scott Schoen , Zhigen Zhao , Ashley Alva , Chengwu Huang , Shigao Chen , Costas Arvanitis

Perfusion by the microcirculation is key to the development, maintenance and pathology of tissue. Its measurement with high spatiotemporal resolution is consequently valuable but remains a challenge in deep tissue. Ultrasound Localization…

Signal Processing · Electrical Eng. & Systems 2023-04-26 Kai Riemer , Matthieu Toulemonde , Jipeng Yan , Marcelo Lerendegui , Eleanor Stride , Peter D. Weinberg , Christopher Dunsby , Meng-Xing Tang

Super-resolution ultrasound imaging with ultrasound localization microscopy (ULM) offers a high-resolution view of microvascular structures. Yet, ULM image quality heavily relies on precise microbubble (MB) detection. Despite the crucial…

Artificial Intelligence · Computer Science 2026-01-15 Sepideh K. Gharamaleki , Brandon Helfield , Hassan Rivaz

Mapping blood microflows of the whole brain is crucial for early diagnosis of cerebral diseases. Ultrasound localization microscopy (ULM) was recently applied to map and quantify blood microflows in 2D in the brain of adult patients down to…

Medical Physics · Physics 2023-04-12 Hugues Favre , Mathieu Pernot , Mickael Tanter , Clément Papadacci

Ultrasound Localization Microscopy (ULM) has presented great potential in functional imaging, benefiting from its ability to reconstruct deep microvasculature. However, the hemodynamic reconstruction is compromised by sparsity in the ULM…

Image and Video Processing · Electrical Eng. & Systems 2026-05-27 Jipeng Yan , Oscar Bates , Jingwen Zhu , Qingyuan Tan , Biao Huang , John Goodwin , Andriy S. Kozlov , Chris Dunsby , Meng-Xing Tang

The-Bodega is a Matlab-based toolbox for simulating ground-truth datasets for Ultrasound Localization Microscopy (ULM)-a super resolution imaging technique that resolves microvessels by systematically tracking microbubbles flowing through…

Mechanisms for non-invasive target drug delivery using microbubbles and ultrasound have attracted growing interest. Microbubbles can be loaded with a therapeutic payload and tracked via ultrasound imaging to selectively release their…

Medical Physics · Physics 2019-02-07 S. Harput , L. Nie , D. M. J. Cowell , T. Carpenter , B. Raiton , J. McLaughlan , S. Freear

Ultrasound offers promising applications in biology and chemistry, but quantifying local ultrasound conditions remains challenging due to the lack of non-invasive measurement tools. We introduce antibubbles as novel optical reporters of…

Imaging the human brain vasculature with high spatial and temporal resolution remains challenging in the clinic today. Transcranial ultrasound is scarcely used for cerebrovascular imaging, due to low sensitivity and strong phase aberrations…

Beamforming in ultrasound imaging has significant impact on the quality of the final image, controlling its resolution and contrast. Despite its low spatial resolution and contrast, delay-and-sum is still extensively used nowadays in…

Computer Vision and Pattern Recognition · Computer Science 2016-05-20 Teodora Szasz , Adrian Basarab , Denis Kouamé

The row-column addressed array is an emerging probe for ultrafast 3-D ultrasound imaging. It achieves this with far fewer independent electronic channels and a wider field of view than traditional 2-D matrix arrays, of the same channel…

Beamforming is an essential step in the ultrasound image formation pipeline and has recently attracted growing interest. An important goal of beamforming is to increase the image spatial resolution, or in other words to narrow down the…

Image and Video Processing · Electrical Eng. & Systems 2022-09-01 Sobhan Goudarzi , Adrian Basarab , Hassan Rivaz

To overcome the half a wavelength resolution limitations of ultrasound imaging, microbubbles (MBs) have been utilized widely in the field. Conventional MB localization methods are limited whether by exhaustive parameter tuning or…

Image and Video Processing · Electrical Eng. & Systems 2023-08-22 Sepideh K. Gharamaleki , Brandon Helfield , Hassan Rivaz