Related papers: Using fluorescent beads to emulate single fluropho…
Optical interferometers increasingly use single-mode fibers as spatial filters to convert varying wavefront distortion into intensity fluctuations which can be monitored for accurate calibration of fringe amplitudes. Here I propose using an…
Optical fibers have altered astronomical instrument design by allowing for a complex, often large instrument to be mounted in a remote and stable location with respect to the telescope. The fibers also enable the possibility to rearrange…
Determining the number of fluorescent entities that are coupled to a given molecule (DNA, protein, etc.) is a key point of numerous biological studies, especially those based on a single molecule approach. Reliable methods are important, in…
A method to create instructive, nonuniform aperture functions using spatial frequency filtering is described. The diffraction from a single slit in the Fresnel limit and the interference from a double slit in the Fraunhofer limit are…
In order to discern aggregation in solutions, we present a quantum mechanical analog of the photon statistics from fluorescent molecules diffusing through a focused beam. A generating functional is developed to fully describe the…
Emerging coherent X-ray scattering patterns of single particles have shown dominant morphological signatures in agreement with predictions of the scattering model used for conventional protein crystallography. The key question is if and to…
An electrostatic hexapole lens is used to manipulate the transverse properties of a beam of barium fluoride molecules from a cryogenic buffer gas source. The spatial distribution of the beam is measured by recording state-selective…
Single molecule rotational correlation functions are analyzed for several reorientation geometries. Even for the simplest model of isotropic rotational diffusion our findings predict non-exponential correlation functions to be observed by…
Micromagnetic beads are widely used in biomedical applications for cell separation, drug delivery, and hypothermia cancer treatment. Here we propose to use self-organized magnetic bead structures which accumulate on fixed magnetic seeding…
Droplet microfluidics combined with optical detection has become a powerful approach for high-throughput single-cell assays, but these systems often face limited sensitivity and signal heterogeneity due to optical and geometrical…
The fluorescence of silicon clusters is reviewed. Atomic clusters of silicon have been at the focus of research for several decades because of the relevance of size effects for material properties, the importance of silicon in electronics…
Lensless flexible fiber-bundle based endoscopes allow imaging at depths beyond the reach of conventional microscopes with a minimal footprint. These multicore fibers provide a simple solution for widefield fluorescent imaging when the…
We present an in-depth study of surface brightness fluctuations (SBFs) in low-luminosity stellar systems. Using the MIST models, we compute theoretical predictions for absolute SBF magnitudes in the LSST, HST ACS/WFC, and proposed Roman…
Optical interference is not only a fundamental phenomenon that has enabled new theories of light to be derived but it has also been used in interferometry for the measurement of small displacements, refractive index changes and surface…
Patient-specific therapies require that cells be manufactured in multiple batches of small volumes, making it a challenge for conventional modes of quality control. The added complexity of inherent variability (even within batches)…
We introduce a new algorithm for interpolating measurements of the point-spread function (PSF) using stars from many exposures. The principal components of the variation in the PSF pattern from multiple exposures are used to solve for…
Multiplexed, real-time fluorescence detection at the single-molecule level is highly desirable to reveal the stoichiometry, dynamics, and interactions of individual molecular species within complex systems. However, traditionally…
Context: Fast Radio Bursts (FRBs) are enigmatic extragalactic bursts whose properties are still largely unknown, but based on their extremely small time duration, they are proposed to have a compact structure, making them candidates for…
Weak gravitational lensing is one of the most powerful tools for cosmology, while subject to challenges in quantifying subtle systematic biases. The Point Spread Function (PSF) can cause biases in weak lensing shear inference when the PSF…
The extensive use of the structure function (SF) in the field of blazar variability suggests that characteristics time-scales are embedded in the light curves of these objects. We argue that for blazar variability studies, the SF results…