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Cortical folding exhibits substantial inter-individual variability while preserving stable anatomical landmarks that enable fine-scale characterization of cortical organization. Among these, the three-hinge gyrus (3HG) serves as a key…

Neurons and Cognition · Quantitative Biology 2026-02-03 Minheng Chen , Tong Chen , Yan Zhuang , Chao Cao , Jing Zhang , Tianming Liu , Lu Zhang , Dajiang Zhu

While some convolutional neural networks (CNNs) have achieved great success in object recognition, they struggle to identify objects in images corrupted with different types of common noise patterns. Recently, it was shown that simulating…

Computer Vision and Pattern Recognition · Computer Science 2023-10-17 Ruxandra Barbulescu , Tiago Marques , Arlindo L. Oliveira

This work presents a procedure to extract morphological information from neuronal cells based on the variation of shape functionals as the cell geometry undergoes a dilation through a wide interval of spatial scales. The targeted shapes are…

Surface analysis of the cortex is ubiquitous in human neuroimaging with MRI, e.g., for cortical registration, parcellation, or thickness estimation. The convoluted cortical geometry requires isotropic scans (e.g., 1mm MPRAGEs) and good…

Image and Video Processing · Electrical Eng. & Systems 2023-05-04 Karthik Gopinath , Douglas N. Greve , Sudeshna Das , Steve Arnold , Colin Magdamo , Juan Eugenio Iglesias

Using demographic data of high spatial resolution for a region in the south of Europe, we study the population over fixed-size spatial cells. We find that, counterintuitively, the distribution of the number of inhabitants per cell increases…

Physics and Society · Physics 2022-12-07 Alvaro Corral , Montserrat García del Muro

Parkinson disease (PD) is marked by progressive neurodegeneration, yet early and subtle structural alterations in brain tissue remain difficult to detect with conventional imaging and analytical methods. Fractal and multifractal frameworks…

Medical Physics · Physics 2025-12-09 Santanu Maity , Mousa Alrubayan , Mohammad Moshahid Khan , Prabhakar Pradhan

It is shown that a Hopfield recurrent neural network exhibits a scaling regime, whose specific exponents depend on the number of parcels used and the decay length of the coupling strength. This scaling regime recovers the picture introduced…

Disordered Systems and Neural Networks · Physics 2025-02-17 Giorgio Gosti , Sauro Succi , Giancarlo Ruocco

Cortical folding reflects coordinated neurodevelopmental processes and provides a sensitive marker of neurological disease. In juvenile myoclonic epilepsy (JME), structural abnormalities are subtle and spatially distributed, limiting the…

Neurons and Cognition · Quantitative Biology 2026-04-21 Moo K. Chung , Luigi Maccotta , Aaron Struck

The quintessential property of neuronal systems is their intensive patterns of selective synaptic connections. The current work describes a physics-based approach to neuronal shape modeling and synthesis and its consideration for the…

Neurons and Cognition · Quantitative Biology 2009-11-10 Luciano da Fontoura Costa , Regina Celia Coelho

The brain is immensely complex, with diverse components and dynamic interactions building upon one another to orchestrate a wide range of functions and behaviors. Understanding patterns of these complex interactions and how they are…

Neurons and Cognition · Quantitative Biology 2024-08-06 Suman Kulkarni , Dani S. Bassett

Evidence of critical dynamics has been recently found in both experiments and models of large scale brain dynamics. The understanding of the nature and features of such critical regime is hampered by the relatively small size of the…

Disordered Systems and Neural Networks · Physics 2019-12-04 Mahdi Zarepour , Juan I. Perotti , Orlando V. Billoni , Dante R. Chialvo , Sergio A. Cannas

In this study we propose a deformation-based framework to jointly model the influence of aging and Alzheimer's disease (AD) on the brain morphological evolution. Our approach combines a spatio-temporal description of both processes into a…

Neurons and Cognition · Quantitative Biology 2019-05-27 Raphaël Sivera , Hervé Delingette , Marco Lorenzi , Xavier Pennec , Nicholas Ayache

We show that fractality in complex networks arises from the geometric self-similarity of their built-in hierarchical community-like structure, which is mathematically described by the scale-invariant equation for the masses of the boxes…

We studied the structural alterations between healthy and diseased brain tissues using a multiparametric framework combining fractal analysis, fractal functional transformation, multifractal analysis, and the Inverse Participation Ratio…

Medical Physics · Physics 2025-12-09 Mousa Alrubayan , Santanu Maity , Prabhakar Pradhan

The curves of scaling behavior is a significant concept in fractal dimension analysis of complex systems. However, the underlying rationale of this kind of curves for fractal cities is not yet clear. The aim of this paper is at researching…

Physics and Society · Physics 2025-08-28 Yanguang Chen

The brain is composed of billions of neurons with virtually endless morphologies and ion channel compositions, resulting in unique extracellular waveforms. Nevertheless, almost all neuronal morphologies can be reduced to a simple…

Neurons and Cognition · Quantitative Biology 2026-01-12 Jérémie Sibille , Kai Lun Teh , Alexandra Tzilivaki , Dietmar Schmitz , Paula T. Kuokkanen

Observations of galaxies over large distances reveal the possibility of a fractal distribution of their positions. The source of fractal behavior is the lack of a length scale in the two body gravitational interaction. However, even with…

Mathematical Physics · Physics 2007-05-23 Bruce N. Miller , Jean-Louis Rouet , Emmanuel Le Guirriec

Since they became observable, neuron morphologies have been informally compared with biological trees but they are studied by distinct communities, neuroscientists, and ecologists. The apparent structural similarity suggests there may be…

Neurons and Cognition · Quantitative Biology 2023-07-06 Roozbeh Farhoodi , Phil Wilkes , Anirudh M. Natarajan , Samantha Ing-Esteves , Julie L. Lefebvre , Mathias Disney , Konrad P. Kording

A curious feature of organ and organoid morphogenesis is that in certain cases, spatial oscillations in the thickness of the growing "film" are out-of-phase with the deformation of the slower-growing "substrate," while in other cases, the…

Biological Physics · Physics 2018-12-26 T. A. Engstrom , Teng Zhang , A. K. Lawton , A. L. Joyner , J. M. Schwarz

The advent of novel opto-genetics technology allows the recording of brain activity with a resolution never seen before. The characterisation of these very large data sets offers new challenges as well as unique theory-testing…

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