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Functional connectivity analysis is an important tool for characterizing interactions among brain regions, particularly in studies of neurodegenerative disorders such as Alzheimer's disease (AD). Gaussian graphical models (GGMs) provide a…

Methodology · Statistics 2026-04-14 Panpan Zhang , Shiying Xiao , W. Hudson Robb , Dandan Liu , Angela L. Jefferson , Jun Yan

We study the problem of discovering the simplest latent variable that can make two observed discrete variables conditionally independent. The minimum entropy required for such a latent is known as common entropy in information theory. We…

Problems of probabilistic inference and decision making under uncertainty commonly involve continuous random variables. Often these are discretized to a few points, to simplify assessments and computations. An alternative approximation is…

Artificial Intelligence · Computer Science 2013-03-08 William B. Poland , Ross D. Shachter

Concepts of Granger causality (GC) and Granger autonomy (GA) are central to assess the dynamics of coupled physiologic processes. While causality measures have been already proposed and applied in time and frequency domains, measures…

Signal Processing · Electrical Eng. & Systems 2023-07-20 Laura Sparacino , Yuri Antonacci , Chiara Barà , Angela Valenti , Alberto Porta , Luca Faes

Granger causality is a statistical notion of causal influence based on prediction via vector autoregression. Developed originally in the field of econometrics, it has since found application in a broader arena, particularly in neuroscience.…

Mathematical Physics · Physics 2015-05-14 Lionel Barnett , Adam B Barrett , Anil K. Seth

Modelling time-varying and frequency-specific relationships between two brain signals is becoming an essential methodological tool to answer heoretical questions in experimental neuroscience. In this article, we propose to estimate a…

Methodology · Statistics 2018-04-16 Sezen Cekic , Didier Grandjean , Olivier Renaud

Information transfer between time series is calculated by using the asymmetric information-theoretic measure known as transfer entropy. Geweke's autoregressive formulation of Granger causality is used to find linear transfer entropy, and…

Data Analysis, Statistics and Probability · Physics 2023-03-24 Z. Keskin , T. Aste

Causality in time series can be challenging to determine, especially in the presence of non-linear dependencies. Granger causality helps analyze potential relationships between variables, thereby offering a method to determine whether one…

Machine Learning · Computer Science 2025-10-13 Harsh Poonia , Felix Divo , Kristian Kersting , Devendra Singh Dhami

This paper proposes a novel method (GLS Granger test) to determine causal relationships between time series based on the estimation of the autocovariance matrix and generalized least squares. We show the effectiveness of proposed…

Methodology · Statistics 2023-01-10 Hugo J. Bello

Dynamic Causal Modelling (DCM) is the predominant method for inferring effective connectivity from neuroimaging data. In the 15 years since its introduction, the neural models and statistical routines in DCM have developed in parallel,…

Quantitative Methods · Quantitative Biology 2019-07-15 Peter Zeidman , Amirhossein Jafarian , Nadège Corbin , Mohamed L. Seghier , Adeel Razi , Cathy J. Price , Karl J. Friston

This paper addresses the problem of inferring circulation of information between multiple stochastic processes. We discuss two possible frameworks in which the problem can be studied: directed information theory and Granger causality. The…

Information Theory · Computer Science 2011-11-02 Pierre-Olivier Amblard , Olivier J. J. Michel

Magnetoencephalography (MEG) is a noninvasive method for measuring magnetic flux signals caused by brain activity using sensor arrays located on or above the scalp. A common strategy for monitoring brain activity is to place sensors on a…

Medical Physics · Physics 2022-05-24 Wan-Jin Yeo , Samu Taulu , J. Nathan Kutz

Neuroscientific studies aim to find an accurate and reliable brain Effective Connectome (EC). Although current EC discovery methods have contributed to our understanding of brain organization, their performances are severely constrained by…

Machine Learning · Computer Science 2024-03-12 Abdolmahdi Bagheri , Mahdi Dehshiri , Yamin Bagheri , Alireza Akhondi-Asl , Babak Nadjar Araabi

Dynamic Causal Modeling (DCM) is a Bayesian framework for inferring on hidden (latent) neuronal states, based on measurements of brain activity. Since its introduction in 2003 for functional magnetic resonance imaging data, DCM has been…

Quantitative Methods · Quantitative Biology 2021-04-08 Inês Pereira , Stefan Frässle , Jakob Heinzle , Dario Schöbi , Cao Tri Do , Moritz Gruber , Klaas E. Stephan

Causal discovery uncovers complex relationships between variables, enhancing predictions, decision-making, and insights into real-world systems, especially in nonlinear multivariate time series. However, most existing methods primarily…

Machine Learning · Computer Science 2025-10-30 Wasim Ahmad , Joachim Denzler , Maha Shadaydeh

Entropic causal inference is a recent framework for learning the causal graph between two variables from observational data by finding the information-theoretically simplest structural explanation of the data, i.e., the model with smallest…

Machine Learning · Computer Science 2025-09-23 Spencer Compton , Kristjan Greenewald , Dmitriy Katz , Murat Kocaoglu

We develop new methods to integrate experimental and observational data in causal inference. While randomized controlled trials offer strong internal validity, they are often costly and therefore limited in sample size. Observational data,…

Econometrics · Economics 2025-11-04 Xuelin Yang , Licong Lin , Susan Athey , Michael I. Jordan , Guido W. Imbens

Continuous glucose monitoring (CGM) is a minimally invasive technology that measures blood glucose every few minutes for weeks or months at a time. CGM data are often collected in the free-living environment and is strongly related to…

Methodology · Statistics 2025-09-04 Marcos Matabuena , Ciprian M. Crainiceanu

This study addresses the problem of learning a summary causal graph on time series with potentially different sampling rates. To do so, we first propose a new causal temporal mutual information measure for time series. We then show how this…

Artificial Intelligence · Computer Science 2023-11-03 Charles K. Assaad , Emilie Devijver , Eric Gaussier

Granger causal inference is a contentious but widespread method used in fields ranging from economics to neuroscience. The original definition addresses the notion of causality in time series by establishing functional dependence…

Methodology · Statistics 2023-09-19 Noah D. Gade , Jordan Rodu