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We present a rigorous mathematical framework for analyzing dynamics of a broad class of Boolean network models. We use this framework to provide the first formal proof of many of the standard critical transition results in Boolean network…

Disordered Systems and Neural Networks · Physics 2016-08-30 C. Seshadhri , Yevgeniy Vorobeychik , Jackson R. Mayo , Robert C. Armstrong , Joseph R. Ruthruff

Here we present a network theory-based approach to investigate the Mack-mode instability signature found in high-speed schlieren data from a Mach 6 laminar boundary layer flow over a $7^\circ$ cone. The data contain instability wave packets…

The problem of reliability of the dynamics in biological regulatory networks is studied in the framework of a generalized Boolean network model with continuous timing and noise. Using well-known artificial genetic networks such as the…

Molecular Networks · Quantitative Biology 2008-05-28 Stefan Braunewell , Stefan Bornholdt

It is an increasingly important problem to study conditions on the structure of a network that guarantee a given behavior for its underlying dynamical system. In this paper we report that a Boolean network may fall within the chaotic…

Molecular Networks · Quantitative Biology 2008-11-04 Winfried Just , German Enciso

Boolean networks are discrete dynamical systems in which the state (zero or one) of each node is updated at each time t to a state determined by the states at time t-1 of those nodes that have links to it. When these systems are used to…

Molecular Networks · Quantitative Biology 2012-02-28 Andrew Pomerance , Michelle Girvan , Ed Ott

The dynamics of noise-resilient Boolean networks with majority functions and diverse topologies is investigated. A wide class of possible topological configurations is parametrized as a stochastic blockmodel. For this class of networks, the…

Disordered Systems and Neural Networks · Physics 2012-01-11 Tiago P. Peixoto

This review explains in a self-contained way the properties of random Boolean networks and their attractors, with a special focus on critical networks. Using small example networks, analytical calculations, phenomenological arguments, and…

Statistical Mechanics · Physics 2008-11-14 Barbara Drossel

Using Boolean networks as prototypical examples, the role of symmetry in the dynamics of heterogeneous complex systems is explored. We show that symmetry of the dynamics, especially in critical states, is a controlling feature that can be…

Statistical Mechanics · Physics 2015-06-19 Shabnam Hossein , Matthew D. Reichl , Kevin E. Bassler

Effective control of biological systems can often be achieved through the control of a surprisingly small number of distinct variables. We bring clarity to such results using the formalism of Boolean dynamical networks, analyzing the…

Molecular Networks · Quantitative Biology 2021-09-13 Enrico Borriello , Bryan C. Daniels

Boolean networks have been the object of much attention, especially since S. Kauffman proposed them in the 1960's as models for gene regulatory networks. These systems are characterized by being defined on a Boolean state space and by…

Molecular Networks · Quantitative Biology 2008-01-30 Winfried Just , German Enciso

The Kauffman model describes a system of randomly connected nodes with dynamics based on Boolean update functions. Though it is a simple model, it exhibits very complex behavior for "critical" parameter values at the boundary between a…

Disordered Systems and Neural Networks · Physics 2007-05-23 Barbara Drossel , Tamara Mihaljev , Florian Greil

We describe all heteroclinic networks in $\mathbb{R}^4$ made of simple heteroclinic cycles of types $B$ or $C$, with at least one common connecting trajectory. For networks made of cycles of type $B$, we study the stability of the cycles…

Dynamical Systems · Mathematics 2016-10-21 Sofia B. S. D. Castro , Alexander Lohse

The theory of complex networks and of disordered systems is used to study the stability and dynamical properties of a simple model of material flow networks defined on random graphs. In particular we address instabilities that are…

Disordered Systems and Neural Networks · Physics 2009-11-13 Kartik Anand , Tobias Galla

Deterministic and stochastic Boolean network models are build for the dynamics of negative feedback loops of the p53 pathways. It is shown that the main function of the negative feedback in the p53 pathways is to keep p53 at a low steady…

Molecular Networks · Quantitative Biology 2009-04-16 Hao Ge , Min Qian

We study the stability of orbits in large Boolean networks with given complex topology. We impose no restrictions on the form of the update rules, which may be correlated with local topological properties of the network. While recent past…

Physics and Society · Physics 2014-09-05 Shane Squires , Andrew Pomerance , Michelle Girvan , Edward Ott

Regulatory dynamics in biology is often described by continuous rate equations for continuously varying chemical concentrations. Binary discretization of state space and time leads to Boolean dynamics. In the latter, the dynamics has been…

Biological Physics · Physics 2013-05-29 Fakhteh Ghanbarnejad , Konstantin Klemm

This paper deals with the global stability of time-delayed dynamical networks. We show that for a time-delayed dynamical network with non-distributed delays the network and the corresponding non-delayed network are both either globally…

Dynamical Systems · Mathematics 2015-06-05 Lenonid Bunimovich , Benjamin Webb

In this paper we investigate equilibria of continuous differential equation models of network dynamics. The motivation comes from gene regulatory networks where each directed edge represents either down- or up-regulation, and is modeled by…

Dynamical Systems · Mathematics 2021-07-08 William Duncan , Tomas Gedeon , Hiroshi Kokubu , Konstantin Mischaikow , Hiroe Oka

A method is presented to analyze the stability of feedback systems with neural network controllers. Two stability theorems are given to prove asymptotic stability and to compute an ellipsoidal inner-approximation to the region of attraction…

Systems and Control · Electrical Eng. & Systems 2021-01-28 He Yin , Peter Seiler , Murat Arcak

We study the properties of the distance between attractors in Random Boolean Networks, a prominent model of genetic regulatory networks. We define three distance measures, upon which attractor distance matrices are constructed and their…

Neural and Evolutionary Computing · Computer Science 2010-11-23 Andrea Roli , Stefano Benedettini , Roberto Serra , Marco Villani