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Introduction: The discovery of causal mechanisms underlying diseases enables better diagnosis, prognosis and treatment selection. Clinical trials have been the gold standard for determining causality, but they are resource intensive,…

Machine Learning · Computer Science 2020-11-12 Xinpeng Shen , Sisi Ma , Prashanthi Vemuri , M. Regina Castro , Pedro J. Caraballo , Gyorgy J. Simon

Electronic Health Record (EHR) data has been of tremendous utility in Artificial Intelligence (AI) for healthcare such as predicting future clinical events. These tasks, however, often come with many challenges when using classical machine…

Machine Learning · Computer Science 2021-04-08 Tingyi Wanyan , Jing Zhang , Ying Ding , Ariful Azad , Zhangyang Wang , Benjamin S Glicksberg

Estimation of heterogeneous treatment effects is an essential component of precision medicine. Model and algorithm-based methods have been developed within the causal inference framework to achieve valid estimation and inference. Existing…

Methodology · Statistics 2021-05-10 Ruohong Li , Honglang Wang , Wanzhu Tu

Electronic health record (EHR) data is collected by individual institutions and often stored across locations in silos. Getting access to these data is difficult and slow due to security, privacy, regulatory, and operational issues. We…

Computers and Society · Computer Science 2018-12-04 Dianbo Liu , Timothy Miller , Raheel Sayeed , Kenneth D. Mandl

Electronic health records (EHRs) offer great promises for advancing precision medicine and, at the same time, present significant analytical challenges. Particularly, it is often the case that patient-level data in EHRs cannot be shared…

Methodology · Statistics 2022-07-04 Changgee Chang , Zhiqi Bu , Qi Long

Causal inference is central to statistics and scientific discovery, enabling researchers to identify cause-and-effect relationships beyond associations. While traditionally studied within Euclidean spaces, contemporary applications…

Methodology · Statistics 2025-07-01 Satarupa Bhattacharjee , Bing Li , Xiao Wu , Lingzhou Xue

Deriving disease subtypes from electronic health records (EHRs) can guide next-generation personalized medicine. However, challenges in summarizing and representing patient data prevent widespread practice of scalable EHR-based…

This PhD thesis contains several contributions to the field of statistical causal modeling. Statistical causal models are statistical models embedded with causal assumptions that allow for the inference and reasoning about the behavior of…

Machine Learning · Statistics 2021-10-05 Martin Emil Jakobsen

Referral workflow inefficiencies, including misaligned referrals and delays, contribute to suboptimal patient outcomes and higher healthcare costs. In this study, we investigated the possibility of predicting procedural needs based on…

The growing adoption of electronic health record (EHR) systems has provided unprecedented opportunities for predictive modeling to guide clinical decision making. Structured EHRs contain longitudinal observations of patients across hospital…

Machine Learning · Computer Science 2026-03-12 Deyi Li , Zijun Yao , Qi Xu , Muxuan Liang , Lingyao Li , Zijian Xu , Mei Liu

Kernel embeddings have emerged as a powerful tool for representing probability measures in a variety of statistical inference problems. By mapping probability measures into a reproducing kernel Hilbert space (RKHS), kernel embeddings enable…

Machine Learning · Statistics 2024-10-31 Dino Sejdinovic

This article presents a novel method for predicting suicidal ideation from Electronic Health Records (EHR) and Ecological Momentary Assessment (EMA) data using deep sequential models. Both EHR longitudinal data and EMA question forms are…

Despite extensive standardization, diagnostic interviews for mental health disorders encompass substantial subjective judgment. Previous studies have demonstrated that EEG-based neural measures can function as reliable objective correlates…

Machine Learning · Computer Science 2020-11-19 Garrett Honke , Irina Higgins , Nina Thigpen , Vladimir Miskovic , Katie Link , Sunny Duan , Pramod Gupta , Julia Klawohn , Greg Hajcak

Today, despite decades of developments in medicine and the growing interest in precision healthcare, vast majority of diagnoses happen once patients begin to show noticeable signs of illness. Early indication and detection of diseases,…

Electronic Health Records (EHR) are high-dimensional data with implicit connections among thousands of medical concepts. These connections, for instance, the co-occurrence of diseases and lab-disease correlations can be informative when…

Machine Learning · Computer Science 2021-03-29 Weicheng Zhu , Narges Razavian

We show how to learn low-dimensional representations (embeddings) of patient visits from the corresponding electronic health record (EHR) where International Classification of Diseases (ICD) diagnosis codes are removed. We expect that these…

Computers and Society · Computer Science 2018-03-28 Jean-Baptiste Escudié , Alaa Saade , Alice Coucke , Marc Lelarge

Embedding models have been an effective learning paradigm for high-dimensional data. However, one open issue of embedding models is that their representations (latent factors) often result in large parameter space. We observe that existing…

Machine Learning · Computer Science 2021-12-15 Xupeng Miao , Hailin Zhang , Yining Shi , Xiaonan Nie , Zhi Yang , Yangyu Tao , Bin Cui

Accurate imputation of missing laboratory values in electronic health records (EHRs) is critical to enable robust clinical predictions and reduce biases in AI systems in healthcare. Existing methods, such as XGBoost, softimpute, GAIN,…

Machine Learning · Computer Science 2025-06-27 David Restrepo , Chenwei Wu , Yueran Jia , Jaden K. Sun , Jack Gallifant , Catherine G. Bielick , Yugang Jia , Leo A. Celi

Owing to the advantages of increased accuracy and the potential to detect unseen patterns, provided by data mining techniques they have been widely incorporated for standard classification problems. They have often been used for high…

Machine Learning · Computer Science 2022-10-05 Anirudha Rayasam , Nagamma Patil

Deep learning models for Electrocardiogram (ECG) diagnosis have achieved remarkable accuracy but exhibit fragility against adversarial perturbations, particularly Smooth Adversarial Perturbations (SAP) that mimic biological morphology.…

Machine Learning · Computer Science 2026-01-01 Shunbo Jia , Caizhi Liao