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We introduce a novel contrastive representation learning objective and a training scheme for clinical time series. Specifically, we project high dimensional EHR. data to a closed unit ball of low dimension, encoding geometric priors so that…

Machine Learning · Computer Science 2022-07-05 Thesath Nanayakkara , Gilles Clermont , Christopher James Langmead , David Swigon

Advancements in machine learning algorithms have had a beneficial impact on representation learning, classification, and prediction models built using electronic health record (EHR) data. Effort has been put both on increasing models'…

Machine Learning · Computer Science 2021-03-24 Yiwen Meng , William Speier , Michael K. Ong , Corey W. Arnold

This study proposes a risk prediction method based on a Multi-Scale Temporal Alignment Network (MSTAN) to address the challenges of temporal irregularity, sampling interval differences, and multi-scale dynamic dependencies in Electronic…

Machine Learning · Computer Science 2025-11-27 Wei-Chen Chang , Lu Dai , Ting Xu

Substantial increase in the use of Electronic Health Records (EHRs) has opened new frontiers for predictive healthcare. However, while EHR systems are nearly ubiquitous, they lack a unified code system for representing medical concepts.…

Machine Learning · Computer Science 2022-03-21 Kyunghoon Hur , Jiyoung Lee , Jungwoo Oh , Wesley Price , Young-Hak Kim , Edward Choi

The non-Euclidean geometry of hyperbolic spaces has recently garnered considerable attention in the realm of representation learning. Current endeavors in hyperbolic representation largely presuppose that the underlying hierarchies can be…

Machine Learning · Computer Science 2023-06-16 Menglin Yang , Min Zhou , Rex Ying , Yankai Chen , Irwin King

Training deep neural networks usually requires a large amount of labeled data to obtain good performance. However, in medical image analysis, obtaining high-quality labels for the data is laborious and expensive, as accurately annotating…

Computer Vision and Pattern Recognition · Computer Science 2020-05-20 Quande Liu , Lequan Yu , Luyang Luo , Qi Dou , Pheng Ann Heng

Electronic health records (EHR) are characterized as non-stationary, heterogeneous, noisy, and sparse data; therefore, it is challenging to learn the regularities or patterns inherent within them. In particular, sparseness caused mostly by…

Machine Learning · Computer Science 2020-03-03 Eunji Jun , Ahmad Wisnu Mulyadi , Jaehun Choi , Heung-Il Suk

Deep learning models achieve strong performance across various domains but often rely on spurious correlations, making them vulnerable to distribution shifts. This issue is particularly severe in subpopulation shift scenarios, where models…

Machine Learning · Computer Science 2026-03-03 Subeen Park , Joowang Kim , Hakyung Lee , Sunjae Yoo , Kyungwoo Song

Causal discovery aims to infer causal relationships among variables from observational data, typically represented by a directed acyclic graph (DAG). Most existing methods assume independent and identically distributed observations, an…

Methodology · Statistics 2026-03-27 Alex Chen , Qing Zhou

Recent advances in deep learning (DL) have prompted the development of high-performing early warning score (EWS) systems, predicting clinical deteriorations such as acute kidney injury, acute myocardial infarction, or circulatory failure.…

Machine Learning · Computer Science 2025-02-05 Yuxiao Cheng , Xinxin Song , Ziqian Wang , Qin Zhong , Kunlun He , Jinli Suo

Missingness in variables that define study eligibility criteria is a seldom addressed challenge in electronic health record (EHR)-based settings. It is typically the case that patients with incomplete eligibility information are excluded…

Clinical outcome prediction based on the Electronic Health Record (EHR) plays a crucial role in improving the quality of healthcare. Conventional deep sequential models fail to capture the rich temporal patterns encoded in the longand…

Machine Learning · Computer Science 2019-08-27 Luchen Liu , Haoran Li , Zhiting Hu , Haoran Shi , Zichang Wang , Jian Tang , Ming Zhang

We present a comprehensive analysis of deep learning approaches for Electronic Health Record (EHR) time-series imputation, examining how architectural and framework biases combine to influence model performance. Our investigation reveals…

Machine Learning · Computer Science 2025-02-05 Linglong Qian , Tao Wang , Jun Wang , Hugh Logan Ellis , Robin Mitra , Richard Dobson , Zina Ibrahim

Building models for health prediction based on Electronic Health Records (EHR) has become an active research area. EHR patient journey data consists of patient time-ordered clinical events/visits from patients. Most existing studies focus…

Machine Learning · Computer Science 2022-07-18 Yuxi Liu , Zhenhao Zhang , Antonio Jimeno Yepes , Flora D. Salim

Background Predicting mortality and resource utilization from electronic health records (EHRs) is challenging yet crucial for optimizing patient outcomes and managing costs in intensive care unit (ICU). Existing approaches predominantly…

Computation and Language · Computer Science 2025-08-29 Yucheng Ruan , Xiang Lan , Daniel J. Tan , Hairil Rizal Abdullah , Mengling Feng

We address the problem of predicting when a disease will develop, i.e., medical event time (MET), from a patient's electronic health record (EHR). The MET of non-communicable diseases like diabetes is highly correlated to cumulative health…

Machine Learning · Computer Science 2023-06-01 Takayuki Katsuki , Kohei Miyaguchi , Akira Koseki , Toshiya Iwamori , Ryosuke Yanagiya , Atsushi Suzuki

Observational causal inference is useful for decision making in medicine when randomized clinical trials (RCT) are infeasible or non generalizable. However, traditional approaches fail to deliver unconfounded causal conclusions in practice.…

Causal inference methods based on electronic health record (EHR) databases must simultaneously handle confounding and missing data. Vast scholarship exists aimed at addressing these two issues separately, but surprisingly few papers attempt…

Methodology · Statistics 2025-07-28 Luke Benz , Alexander Levis , Sebastien Haneuse

Latent space models are widely used for analyzing high-dimensional discrete data matrices, such as patient-feature matrices in electronic health records (EHRs), by capturing complex dependence structures through low-dimensional embeddings.…

Machine Learning · Computer Science 2026-02-19 Weijing Tang , Ming Yuan , Zongqi Xia , Tianxi Cai

Electronic health records (EHR) consist of longitudinal clinical observations portrayed with sparsity, irregularity, and high-dimensionality, which become major obstacles in drawing reliable downstream clinical outcomes. Although there…

Machine Learning · Computer Science 2020-11-17 Ahmad Wisnu Mulyadi , Eunji Jun , Heung-Il Suk