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Inspired by motile cells in tissue formation, we find that active systems of self-aligning adhesive particles undergo ballistic aggregation through a flocking transition. This kinetic regime emerges when the cluster persistence length grows…

Single and collective cell migration are fundamental processes critical for physiological phenomena ranging from embryonic development and immune response to wound healing and cancer metastasis. To understand cell migration from a physical…

Biological Physics · Physics 2023-10-10 David B. Brückner , Chase P. Broedersz

Collective migration -- the directed, coordinated motion of many self-propelled agents -- is a fascinating emergent behavior exhibited by active matter that has key functional implications for biological systems. Extensive studies have…

Biological Physics · Physics 2022-06-07 Tapomoy Bhattacharjee , Daniel B. Amchin , Ricard Alert , J. A. Ott , Sujit S. Datta

We consider a system of two kinetic equations modelling a multicellular system : The first equation governs the dynamics of cells, whereas the second kinetic equation governs the dynamics of the chemoattractant. For this system, we first…

Analysis of PDEs · Mathematics 2019-07-30 Mohamed Khaladi , Nisrine Outada , Nicolas Vauchelet

Chemically active droplets provide simple models for cell-like systems that can grow and divide. Such active droplet systems are driven away from thermodynamic equilibrium and turn over chemically, which corresponds to a simple metabolism.…

Biological Physics · Physics 2022-09-28 Jonathan Bauermann , Christoph A. Weber , Frank Jülicher

The transition from a microscopic model for the movement of many particles to a macroscopic continuum model for a density flow is studied. The microscopic model for the free flow is completely deterministic, described by an interaction…

Statistical Mechanics · Physics 2021-01-12 Jennifer Weissen , Simone Göttlich , Dieter Armbruster

We introduce and study a family of cooperative exclusion processes whose microscopic dynamics is governed by selective kinetic constraints. They display, in sharp contrast to the simple symmetric exclusion process, density profiles that can…

Statistical Mechanics · Physics 2019-11-27 Mauro Sellitto

When particles move at a constant speed and have the tendency to align their directions of motion, ordered large scale movement can emerge despite significant levels of noise. Many variants of this model of self-propelled particles have…

Biological Physics · Physics 2012-12-11 Matthias Meschede , Oskar Hallatschek

The logistic equation is ubiquitous in applied mathematics as a minimal model of saturating growth. Here, we examine a broad generalisation of the logistic growth model to discretely structured populations, motivated by examples that range…

Populations and Evolution · Quantitative Biology 2025-05-15 Benjamin J. Walker , Helen M. Byrne

A model describing the competition of two species for a common nutrient is studied. It is assumed that one of the competitors is motionless while the other has the ability to move upwards gradients of the nutrient density. It is proved that…

Analysis of PDEs · Mathematics 2018-05-31 Piotr Krzyzanowski , Michael Winkler , Dariusz Wrzosek

We present a simple model for describing the dynamics of the interaction between a homogeneous population or society, and the natural resources and reserves that the society needs for its survival. The model is formulated in terms of…

Physics and Society · Physics 2020-04-22 Basil Grammaticos , Ralph Willox , Junkichi Satsuma

A number of biological processes, such as embryo development, cancer metastasis or wound healing, rely on cells moving in concert. The mechanisms leading to the emergence of coordinated motion remain however largely unexplored. Although…

Cell Behavior · Quantitative Biology 2011-08-23 Alexandre J Kabla

Stochastic models of diffusion with excluded-volume effects are used to model many biological and physical systems at a discrete level. The average properties of the population may be described by a continuum model based on partial…

Chemical Physics · Physics 2012-12-20 Maria Bruna , S. Jonathan Chapman

This paper addresses congested transport, which can be described, at macroscopic scales, by a continuity equation with a pressure variable generated from the hard-congestion constraint (maximum value of the density). The main goal of the…

Analysis of PDEs · Mathematics 2024-05-27 Inwon Kim , Antoine Mellet , Jeremy Sheung-Him Wu

In systems as diverse as migrating mammals to road traffic, crowding acts to inhibit efficient collective movement. Bacteria, however, are observed to move in very dense groups containing billions of individuals without causing the gridlock…

An imbalance between energy intake and energy expenditure will lead to a change in body weight (mass) and body composition (fat and lean masses). A quantitative understanding of the processes involved, which currently remains lacking, will…

Tissues and Organs · Quantitative Biology 2015-05-13 Carson C. Chow , Kevin D. Hall

Collective motion of cells is critical to some of the most vital tasks including wound healing, development, and immune response [Friedl and Gilmour 2009; Tokarski et al. 2012; Lee et al. 2012; Beltman et al. 2009], and is common to many…

Cell Behavior · Quantitative Biology 2014-07-04 Mircea Davidescu , Iain Couzin

Diffusion is a fundamental phenomenon that occurs ubiquitously in nature and remains the subject of continuous research interest. Understanding diffusion is a key to understanding leaving systems. In this Chapter, I discuss diffusion of…

Soft Condensed Matter · Physics 2018-10-15 Svyatoslav Kondrat

This paper establishes existence, uniqueness, and an L^1-comparison principle for weak solutions of a PDE system modeling phase transition reaction-diffusion in congested crowd motion. We consider a general reaction term and mixed…

Analysis of PDEs · Mathematics 2025-09-17 Noureddine Igbida , Fahd Karami , Driss Meskine

We analyse collective motion that occurs during rare (large deviation) events in systems of active particles, both numerically and analytically. We discuss the associated dynamical phase transition to collective motion, which occurs when…

Statistical Mechanics · Physics 2021-02-10 Yann-Edwin Keta , Étienne Fodor , Frédéric van Wijland , Michael E. Cates , Robert L. Jack