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We report on a novel flow-based method for high-precision chemical detection that integrates quantum sensing with droplet microfluidics. We deploy nanodiamond particles hosting fluorescent nitrogen vacancy defects as quantum sensors in…

A flow-through sensing platform based on open-ended porous silicon (PSi) microcavity membranes that are compatible with integration in on-chip sensor arrays is demonstrated. Due to the high aspect ratio of PSi nanopores, the performance of…

Materials Science · Physics 2016-10-27 Yiliang Zhao , Girija Gaur , Scott T. Retterer , Paul E. Laibinis , Sharon M. Weiss

The mechanical properties of biological fluids can serve as early indicators of disease, offering valuable insights into complex physiological and pathological processes. However, the existing technologies can hardly support high throughput…

Optics · Physics 2025-09-18 Zhonghao Li , Zhihan Cai , Chaoyang Gong

Fluorescence labeling is the standard approach to reveal cellular structures and other subcellular constituents for microscopy images. However, this invasive procedure may perturb or even kill the cells and the procedure itself is highly…

Image and Video Processing · Electrical Eng. & Systems 2024-06-25 Han Liu , Hao Li , Jiacheng Wang , Yubo Fan , Zhoubing Xu , Ipek Oguz

We report efforts to quantify the loading of cell-sized lipid vesicles using in-line digital holographic microscopy. This method does not require fluorescent reporters, fluorescent tracers, or radioactive tracers. A single-color LED light…

Artificial intelligence has significantly advanced the automation of diagnostic processes, benefiting various fields including agriculture. This study introduces an AI-based system for the automatic diagnosis of urban street plants using…

Computer Vision and Pattern Recognition · Computer Science 2024-07-04 Marc Josep Montagut Marques , Liu Mingxin , Kuri Thomas Shiojiri , Tomika Hagiwara , Kayo Hirose , Kaori Shiojiri , Shinjiro Umezu

Absolute quantity imaging of biomolecules on a single cell level is critical for measurement assurance in biosciences and bioindustries. While infrared (IR) transmission microscopy is a powerful label-free imaging modality capable of…

Quantitative Methods · Quantitative Biology 2024-03-29 Yow-Ren Chang , Seong-Min Kim , Young Jong Lee

A surface plasmon resonance imaging biosensor based on $\text{MoS}_2$ deposited on Aluminium substrate is designed for high imaging sensitivity and detection accuracy. The proposed biosensor exhibits better performance than graphene-based…

Mesoscale and Nanoscale Physics · Physics 2018-12-19 Yi Xu , Lin Wu , Lay Kee Ang

Many medical and biological protocols for analyzing individual biological cells involve morphological evaluation based on cell staining, designed to enhance imaging contrast and enable clinicians and biologists to differentiate between…

Rapid identification of microparticles in liquid is an important problem in environmental and biomedical applications such as for microplastic detection in water sources and physiological fluids. Existing spectro-scopic techniques are…

Applied Physics · Physics 2024-11-20 Yagmur Ceren Alatas , Uzay Tefek , Sayedus Salehin , Hashim Alhmoud , M. Selim Hanay

The presence of clouds between an airshower and a space-based detector can dramatically alter the measured signal characteristics due to absorption and scattering of the photonic signals. Furthermore, knowledge of the cloud cover in the…

Astrophysics · Physics 2007-05-23 John Krizmanic , Pierre Sokolsky , Robert Streitmatter

Fiber imaging bundles are widely used as thin, passive image conduits for miniaturised and endoscopic microscopy, particularly for confocal fluorescence imaging. Holographic microscopy through fiber bundles is more challenging; phase…

Optics · Physics 2020-10-28 Michael R Hughes

This paper presents a vision-based Unscented FastSLAM (UFastSLAM) algorithm combing the Rao-Blackwellized particle filter and Unscented Kalman filte(UKF). The landmarks are detected by a binocular vision to integrate localization and…

Robotics · Computer Science 2019-05-09 Chunxin Qiu , Xiaorui Zhu , Xiaobing Zhao

Wearable sensing technology capable of point-of-care, continuous and non-invasive analysis of exosomes in biofluid such as tears and sweat is an essential part for future personalized medicine. Major detection and identification methods of…

Mesoscale and Nanoscale Physics · Physics 2026-05-26 Yang Li , Xiaoming Lyu , Ling Xia , Kuo Zhan , Haoyu Ji , Lei Qin , Seppo J. Vainio , Jian-An Huang

We present a comprehensive study on fully automated pollen recognition across both conventional optical and digital in-line holographic microscopy (DIHM) images of sample slides. Visually recognizing pollen in unreconstructed holographic…

Computer Vision and Pattern Recognition · Computer Science 2025-12-25 Swarn S. Warshaneyan , Maksims Ivanovs , Blaž Cugmas , Inese Bērziņa , Laura Goldberga , Mindaugas Tamosiunas , Roberts Kadiķis

Fluorescence imaging and spectroscopy remain the most powerful tools for visualization with chemical and immunological specificity of labeled biomolecules, viruses, cellular organelles, and living cells in complex biological backgrounds.…

Environmental acoustic sensing involves the retrieval and processing of audio signals to better understand our surroundings. While large-scale acoustic data make manual analysis infeasible, they provide a suitable playground for machine…

Machine Learning · Statistics 2017-12-08 Yunpeng Li , Ivan Kiskin , Davide Zilli , Marianne Sinka , Henry Chan , Kathy Willis , Stephen Roberts

Flexible photonics offers the possibility to realize wearable sensors by bridging the advantages of flexible materials and photonic sensing elements. Recently, optical resonators have emerged as a tool to improve its over sensitivity by…

Optics · Physics 2023-12-22 Ningyuan Nie , Yu-Cheng Chen

Droplet microlasers, as promising tools for biophotonics and biomedical sciences, have witnessed rapid advances due to their flexible reconfigurability, high sensitivity to stimuli, and label-free biosensing ability. However, designing…

Holotomography (HT) has revolutionized quantitative label-free 3D imaging, yet conventional lens-based implementations are fundamentally constrained in field-of-view (FOV) and imaging depth, limiting their utility for critical…

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