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Blood leukocytes can exhibit extensive morphological changes during their passage through small capillary vessels. The human monocytic THP-1 cell line was used to explore the metabolic dependence of these shape changes. Cells were aspirated…
Dimensionality reduction is a crucial technique in data analysis, as it allows for the efficient visualization and understanding of high-dimensional datasets. The circular coordinate is one of the topological data analysis techniques…
A new nonlinear hyperelastic bending model for shells formulated directly in surface form is presented, and compared to four prominently used bending models. Through an essential set of elementary nonlinear bending test cases, the stresses…
Automatic cell detection in histology images is a challenging task due to varying size, shape and features of cells and stain variations across a large cohort. Conventional deep learning methods regress the probability of each pixel…
We study the rheology of dry and wet granular materials in the steady quasistatic regime using the Discrete Element Method (DEM) in a split-bottom ring shear cell with focus on the macroscopic friction. The aim of our study is to understand…
De-homogenization is becoming an effective method to significantly expedite the design of high-resolution multiscale structures, but existing methods have thus far been confined to simple static compliance minimization. There are two…
We use mesoscale numerical simulations to investigate the unsteady dynamics of a single red blood cell (RBC) subjected to an external mechanical load. We carry out a detailed comparison between the {\it loading} (L) dynamics, following the…
This paper presents a comprehensive experimental validation of a recently developed Ray Deflection Function (RDF) approach, which offers a new framework for modeling surface roughness effects in optical systems. Through detailed geometrical…
Wood-composite materials are widely used today as they homogenize humidity related directional deformations. Quantification of these deformations as coefficients is important for construction and engineering and topic of current research…
Cryo-electron tomography (Cryo-ET) is a 3D imaging technique that enables the systemic study of shape, abundance, and distribution of macromolecular structures in single cells in near-atomic resolution. However, the systematic and efficient…
Commonly used linear and nonlinear constitutive material models in deformation simulation contain many simplifications and only cover a tiny part of possible material behavior. In this work we propose a framework for learning customized…
Standard cells form the building blocks of digital circuits, so their delay and power critically influence chip-level performance; yet characterization still relies on slow simulation sweeps, and many fast predictors ignore layout geometry,…
This paper investigates how the measurement of geometrical features of structures obtained from ballistic deposition of objects with complex shapes, particularly neuronal cells, can be used for characterization and analysis of the shapes…
The Materials Project crystal structure database has been searched for materials possessing layered motifs in their crystal structures using a topology-scaling algorithm. The algorithm identifies and measures the sizes of bonded atomic…
The purpose of this work is the development and determination of higher-order continuum-like kinematic measures which characterize discrete kinematic data obtained from experimental measurement (e.g., digital image correlation) or kinematic…
Many media are divided into elementary units with irregular shape and size, as exemplified by domains in magnetic materials, bubbles in foams, or cells in biological tissues. Such media are essentially characterized by geometrical disorder…
Covariant density functional theory (CDFT) is a modern theoretical tool for the description of nuclear structure phenomena. The current investigation aims at the global assessment of the accuracy of the description of the ground state…
The rich chemical information from tissue metabolomics provides a powerful means to elaborate tissue physiology or tumor characteristics at cellular and tumor microenvironment levels. However, the process of obtaining such information…
Cell-cell adhesion is one the most fundamental mechanisms regulating collective cell migration during tissue development, homeostasis and repair, allowing cell populations to self-organize and eventually form and maintain complex tissue…
Radiation therapy presents a need for dynamic tracking of a target tumor volume. Fiducial markers such as implanted gold seeds have been used to gate radiation delivery but the markers are invasive and gating significantly increases…