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Bone marrow cytology is required to make a hematological diagnosis, influencing critical clinical decision points in hematology. However, bone marrow cytology is tedious, limited to experienced reference centers and associated with high…

Image and Video Processing · Electrical Eng. & Systems 2021-07-09 Rohollah Moosavi Tayebi , Youqing Mu , Taher Dehkharghanian , Catherine Ross , Monalisa Sur , Ronan Foley , Hamid R. Tizhoosh , Clinton JV Campbell

Growth-elasticity is a powerful model framework for understanding complex shape development in soft biological tissues. At each instant, by mapping how continuum building blocks have grown geometrically and how they respond elastically to…

Numerical Analysis · Mathematics 2024-10-23 Min Wu

Sorting cells based on their intrinsic properties is a highly desirable objective, since changes in cell deformability are often associated with various stress conditions and diseases. Deterministic lateral displacement (DLD) devices offer…

Fluid Dynamics · Physics 2024-06-03 Zunmin Zhang , Wei Chien , Ewan Henry , Dmitry A. Fedosov , Gerhard Gompper

The connection between the properties of cell tissue and those of the single constituent cells remains to be elucidated. At the purely mechanical level, the degree of rigidity of different cellular components, such as the nucleus and the…

Soft Condensed Matter · Physics 2022-03-15 Stefano Villa , Andrea Palamidessi , Emanuela Frittoli , Giorgio Scita , Roberto Cerbino , Fabio Giavazzi

Understanding lattice deformations is crucial in determining the properties of nanomaterials, which can become more prominent in future applications ranging from energy harvesting to electronic devices. However, it remains challenging to…

Computational cytology is a critical, rapid-developing, yet challenging topic in the field of medical image computing which analyzes the digitized cytology image by computer-aided technologies for cancer screening. Recently, an increasing…

Image and Video Processing · Electrical Eng. & Systems 2023-03-21 Hao Jiang , Yanning Zhou , Yi Lin , Ronald CK Chan , Jiang Liu , Hao Chen

Identifying, measuring and reporting lesions accurately and comprehensively from patient CT scans are important yet time-consuming procedures for physicians. Computer-aided lesion/significant-findings detection techniques are at the core of…

Computer Vision and Pattern Recognition · Computer Science 2020-09-01 Jinzheng Cai , Ke Yan , Chi-Tung Cheng , Jing Xiao , Chien-Hung Liao , Le Lu , Adam P. Harrison

To insight the relationships between the self-organizing structures of cells, such as the cell clusters, and the properties of biotissues is helpful in revealing the function and designing biomaterial. Traditional random foam model neglects…

Soft Condensed Matter · Physics 2017-06-07 Xiaohua Zhou , Erhu Zhang , Minggang Xia , Jianlin Liu , Shengli Zhang

Lookup tables (LUTs) are frequently used to efficiently store arrays of precomputed values for complex mathematical computations. When used in the context of neural networks, these functions exhibit a lack of recognizable patterns which…

Hardware Architecture · Computer Science 2025-01-03 Oliver Cassidy , Marta Andronic , Samuel Coward , George A. Constantinides

Deep learning has achieved spectacular performance in image and speech recognition and synthesis. It outperforms other machine learning algorithms in problems where large amounts of data are available. In the area of measurement technology,…

Quantitative Methods · Quantitative Biology 2019-08-20 Yueqin Li , Ata Mahjoubfar , Claire Lifan Chen , Kayvan Reza Niazi , Li Pei , Bahram Jalali

To investigate the interplay between microscopic dynamics and macroscopic rheology in soft matter, we couple a stress-controlled-rheometer equipped with a Couette cell to a light scattering setup in the imaging geometry, which allows us to…

Soft Condensed Matter · Physics 2016-11-23 N. Ali , DCD. Roux , L. Cipelletti , F. Caton

This paper describes and validates for the first time the dynamic modelling of Liquid Crystal (LC)-based planar multi-resonant cells, as well as its use as bias signals synthesis tool to improve their reconfigurability time. The dynamic LC…

In the emerging field of 3D bioprinting, cell damage due to large deformations is considered a main cause for cell death and loss of functionality inside the printed construct. Those deformations, in turn, strongly depend on the…

The phase-field method has become in recent years the method of choice for simulating microstructural pattern formation during solidification. One of its main advantages is that time-dependent three-dimensional simulations become feasible.…

Materials Science · Physics 2007-05-23 M. Dejmek , R. Folch , A. Parisi , M. Plapp

Topological defects are a ubiquitous phenomenon in diverse physical systems. In nematic liquid crystals (LCs), they are dynamic, physicochemically distinct, sensitive to stimuli, and are thereby promising for a range of applications.…

Soft Condensed Matter · Physics 2023-12-25 Shengzhu Yi , Hao Chen , Xinyu Wang , Miao Jiang , Bo Li , Qi-huo Wei , Rui Zhang

Purpose: Lung nodules have very diverse shapes and sizes, which makes classifying them as benign/malignant a challenging problem. In this paper, we propose a novel method to predict the malignancy of nodules that have the capability to…

Computer Vision and Pattern Recognition · Computer Science 2019-04-24 Mundher Al-Shabi , Boon Leong Lan , Wai Yee Chan , Kwan-Hoong Ng , Maxine Tan

The deformability of human red blood cells (RBCs), which comprise almost 99% of the cells in whole blood, is largely related not only to pathophysiological blood flow but also to the levels of intracellular compounds. Therefore, statistical…

Here, we derive the equations to calculate the effective viscosity of solutions of methyl cellulose (MC) dissolved in phosphate buffered saline (PBS) in real-time deformability cytometry (RT-DC) experiments. The calculations are based on…

Soft Condensed Matter · Physics 2023-02-09 Felix Reichel , Beyza Büyükurgancı

Detecting and classifying cells in histopathology H\&E stained whole-slide images is a core task in computational pathology, as it provides valuable insight into the tumor microenvironment. In this work we investigate the impact of ground…

Image and Video Processing · Electrical Eng. & Systems 2023-12-20 Lydia A. Schoenpflug , Viktor H. Koelzer

The development of traction-force microscopy, in the past two decades, has created the unprecedented opportunity of performing direct mechanical measurements on living cells as they adhere or crawl on uniform or micro-patterned substrates.…

Biological Physics · Physics 2019-10-25 Luca Giomi