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Amyotrophic lateral sclerosis (ALS) is incurable neurological disorder with rapidly progressive course. Common early symptoms of ALS are difficulty in swallowing and speech. However, early acoustic manifestation of speech and voice symptoms…

Sound · Computer Science 2021-01-12 Maxim Vashkevich , Yulia Rushkevich

The analysis of speech in individuals with amyotrophic lateral sclerosis is a powerful tool to support clinicians in the assessment of bulbar dysfunction. However, current methods used in clinical practice consist of subjective evaluations…

Audio and Speech Processing · Electrical Eng. & Systems 2025-05-28 Francesco Pierotti , Andrea Bandini

Large Language Models (LLMs) are increasingly used in Spoken Language Understanding (SLU), where effective multimodal learning depends on the alignment between audio and text. Despite various fusion methods, no standard metric exists to…

Computation and Language · Computer Science 2025-07-08 Pooneh Mousavi , Yingzhi Wang , Mirco Ravanelli , Cem Subakan

We propose a cloud-based multimodal dialog platform for the remote assessment and monitoring of Amyotrophic Lateral Sclerosis (ALS) at scale. This paper presents our vision, technology setup, and an initial investigation of the efficacy of…

Automatic prediction of amyotrophic lateral sclerosis (ALS) disease progression provides a more efficient and objective alternative than manual approaches. We propose ALS longitudinal speech transformer (ALST), a neural network-based…

On average the lack of biological markers causes a one year diagnostic delay to detect amyotrophic lateral sclerosis (ALS). To improve the diagnostic process an automatic voice assessment based on acoustic analysis can be used. The purpose…

Sound · Computer Science 2020-03-25 Maxim Vashkevich , Alexander Petrovsky , Yuliya Rushkevich

Diagnosing autism spectrum disorder (ASD) by identifying abnormal speech patterns from examiner-patient dialogues presents significant challenges due to the subtle and diverse manifestations of speech-related symptoms in affected…

Sound · Computer Science 2024-05-09 Chuanbo Hu , Jacob Thrasher , Wenqi Li , Mindi Ruan , Xiangxu Yu , Lynn K Paul , Shuo Wang , Xin Li

Background: An early diagnosis together with an accurate disease progression monitoring of multiple sclerosis is an important component of successful disease management. Prior studies have established that multiple sclerosis is correlated…

Audio and Speech Processing · Electrical Eng. & Systems 2021-09-28 Emil Svoboda , Tomáš Bořil , Jan Rusz , Tereza Tykalová , Dana Horáková , Charles R. G. Guttman , Krastan B. Blagoev , Hiroto Hatabu , Vlad I. Valtchinov

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and memory loss. Early detection of AD is crucial for effective intervention and treatment. In this paper, we propose a novel approach…

Audio and Speech Processing · Electrical Eng. & Systems 2025-04-29 Yu Pu , Wei-Qiang Zhang

Amyotrophic lateral sclerosis is a fatal disease that not only affects movement, speech, and breath but also cognition. Recent studies have focused on the use of language analysis techniques to detect ALS and infer scales for monitoring…

Computation and Language · Computer Science 2023-09-14 Carla Agurto , Guillermo Cecchi , Bo Wen , Ernest Fraenkel , James Berry , Indu Navar , Raquel Norel

The average life expectancy is increasing globally due to advancements in medical technology, preventive health care, and a growing emphasis on gerontological health. Therefore, developing technologies that detect and track aging-associated…

Computational Engineering, Finance, and Science · Computer Science 2022-09-14 Saurav K. Aryal , Howard Prioleau , Legand Burge

Compared to other clinical screening techniques, speech-and-language-based automated Alzheimer's disease (AD) detection methods are characterized by their non-invasiveness, cost-effectiveness, and convenience. Previous studies have…

Audio and Speech Processing · Electrical Eng. & Systems 2024-12-10 Yin-Long Liu , Rui Feng , Jia-Hong Yuan , Zhen-Hua Ling

Background: Speech and language pathologists (SLPs) often relyon judgements of speech fluency for diagnosing or monitoringpatients with aphasia. However, such subjective methods havebeen criticised for their lack of reliability and their…

Computation and Language · Computer Science 2023-08-10 Lionel Fontan , Typhanie Prince , Aleksandra Nowakowska , Halima Sahraoui , Silvia Martinez-Ferreiro

Automated speaking assessment (ASA) typically involves automatic speech recognition (ASR) and hand-crafted feature extraction from the ASR transcript of a learner's speech. Recently, self-supervised learning (SSL) has shown stellar…

Sound · Computer Science 2025-03-04 Tien-Hong Lo , Fu-An Chao , Tzu-I Wu , Yao-Ting Sung , Berlin Chen

Although personalized automatic speech recognition (ASR) models have recently been designed to recognize even severely impaired speech, model performance may degrade over time for persons with degenerating speech. The aims of this study…

Audio and Speech Processing · Electrical Eng. & Systems 2022-11-02 Katrin Tomanek , Katie Seaver , Pan-Pan Jiang , Richard Cave , Lauren Harrel , Jordan R. Green

Automatic speech recognition (ASR) systems have dramatically improved over the last few years. ASR systems are most often trained from 'typical' speech, which means that underrepresented groups don't experience the same level of…

Speech processing techniques are useful for analyzing speech and language development in children with Autism Spectrum Disorder (ASD), who are often varied and delayed in acquiring these skills. Early identification and intervention are…

Audio and Speech Processing · Electrical Eng. & Systems 2023-06-02 Anfeng Xu , Rajat Hebbar , Rimita Lahiri , Tiantian Feng , Lindsay Butler , Lue Shen , Helen Tager-Flusberg , Shrikanth Narayanan

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by a rapid motor decline, leading to respiratory failure and subsequently to death. In this context, researchers have sought for models to automatically…

Machine Learning · Computer Science 2019-07-31 Telma Pereira , Sofia Pires , Marta Gromicho , Susana Pinto , Mamede de Carvalho , Sara C. Madeira

Lipreading or visually recognizing speech from the mouth movements of a speaker is a challenging and mentally taxing task. Unfortunately, multiple medical conditions force people to depend on this skill in their day-to-day lives for…

Computer Vision and Pattern Recognition · Computer Science 2021-11-04 Bipasha Sen , Aditya Agarwal , Rudrabha Mukhopadhyay , Vinay Namboodiri , C V Jawahar

Alzheimer's Disease (AD) is nowadays the most common form of dementia, and its automatic detection can help to identify symptoms at early stages, so that preventive actions can be carried out. Moreover, non-intrusive techniques based on…

Computation and Language · Computer Science 2020-11-21 Mireia Farrús , Joan Codina-Filbà
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