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Multimodal MRI offers complementary multi-scale information to characterize the brain structure. However, it remains challenging to effectively integrate multimodal MRI while achieving neuroscience interpretability. Here we propose to use…
Differential Dynamic Microscopy (DDM) analyzes traditional real-space microscope images to extract information on sample dynamics in a way akin to light scattering, by decomposing each image in a sequence into Fourier modes, and evaluating…
The accuracy of deformable image registration (DIR) has a significant dosimetric impact in radiation treatment planning. We evaluated accuracy of various DIR algorithms using variations of the deformation point and volume. The reference…
This work proposes NePhi, a generalizable neural deformation model which results in approximately diffeomorphic transformations. In contrast to the predominant voxel-based transformation fields used in learning-based registration…
We introduce the Push-Forward Signed Distance Morphometric (PF-SDM) for shape quantification in biomedical imaging. The PF-SDM compactly encodes geometric and topological properties of closed shapes, including their skeleton and symmetries.…
Understanding how networks of neurons process information is one of the key challenges in modern neuroscience. A necessary step to achieve this goal is to be able to observe the dynamics of large populations of neurons over a large area of…
This paper introduces the Neural Differential Manifold (NDM), a novel neural network architecture that explicitly incorporates geometric structure into its fundamental design. Departing from conventional Euclidean parameter spaces, the NDM…
Brain mapping research in most neuroanatomical laboratories relies on conventional processing techniques, which often introduce histological artifacts such as tissue tears and tissue loss. In this paper we present techniques and algorithms…
Spatially aligning medical images from different modalities remains a challenging task, especially for intraoperative applications that require fast and robust algorithms. We propose a weakly-supervised, label-driven formulation for…
Partial shapes correspondences is a problem that often occurs in computer vision (occlusion, evolution in time...). In medical imaging, data may come from different modalities and be acquired under different conditions which leads to…
Brain-to-image decoding has been recently propelled by the progress in generative AI models and the availability of large ultra-high field functional Magnetic Resonance Imaging (fMRI). However, current approaches depend on complicated…
Understanding and predicting the progression of neurodegenerative diseases remains a major challenge in medical AI, with significant implications for early diagnosis, disease monitoring, and treatment planning. However, most available…
Deep learning has proven to successfully learn variations in tissue and cell morphology. Training of such models typically relies on expensive manual annotations. Here we conjecture that spatially resolved gene expression, e.i., the…
Recent advances in imaging and high-performance computing have made it possible to image the entire human brain at the cellular level. This is the basis to study the multi-scale architecture of the brain regarding its subdivision into brain…
We propose a novel machine learning strategy for studying neuroanatomical shape variation. Our model works with volumetric binary segmentation images, and requires no pre-processing such as the extraction of surface points or a mesh. The…
In cognitive science and AI, a longstanding question is whether machines learn representations that align with those of the human mind. While current models show promise, it remains an open question whether this alignment is superficial or…
The segmentation of substantial brain lesions is a significant and challenging task in the field of medical image segmentation. Substantial brain lesions in brain imaging exhibit high heterogeneity, with indistinct boundaries between lesion…
We present a novel algorithm named 3DPIFCM, for automatic segmentation of noisy MRI Brain images. The algorithm is an extension of a well-known IFCM (Improved Fuzzy C-Means) algorithm. It performs fuzzy segmentation and introduces a fitness…
Statistical shape modeling is an essential tool for the quantitative analysis of anatomical populations. Point distribution models (PDMs) represent the anatomical surface via a dense set of correspondences, an intuitive and easy-to-use…
This article introduces a full mathematical and numerical framework for treating functional shapes (or fshapes) following the landmarks of shape spaces and shape analysis. Functional shapes can be described as signal functions supported on…