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Microwell microfluidics has been utilized for single-cell analysis to reveal heterogeneity in gene expression, signaling pathways, and phenotypic responses for identifying rare cell types, understanding disease progression, and developing…
Abdominal organ segmentation from CT and MRI is an essential prerequisite for surgical planning and computer-aided navigation systems. It is challenging due to the high variability in the shape, size, and position of abdominal organs.…
Segmentation is often an essential intermediate step in image analysis. A volume segmentation characterizes the underlying volume image in terms of geometric information--segments, faces between segments, curves in which several faces…
Fueled by recent advances in machine learning, there has been tremendous progress in the field of semantic segmentation for the medical image computing community. However, developed algorithms are often optimized and validated by hand based…
We propose a mesh-based technique to aid in the classification of Alzheimer's disease dementia (ADD) using mesh representations of the cortex and subcortical structures. Deep learning methods for classification tasks that utilize structural…
Diffusion magnetic resonance imaging (dMRI) is a crucial non-invasive technique for exploring the microstructure of the living human brain. Traditional hand-crafted and model-based tissue microstructure reconstruction methods often require…
We derive an algorithm for compression of the currents and varifolds representations of shapes, using ridge leverage score (RLS) sampling, and the theory of Nystrom approximation in Reproducing Kernel Hilbert Spaces. Our method is faster…
In-scanner motion degrades the quality of magnetic resonance imaging (MRI) thereby reducing its utility in the detection of clinically relevant abnormalities. We introduce a deep learning-based MRI artifact reduction model (DMAR) to…
We extend the Locally-Subdivided Neural Intersection Function (LSNIF) to support parameterized deformable and animated geometry. Our approach introduces a rest-space and deformed-space formulation inspired by meshless rendering, allowing…
To build the connectomics map of the brain, we developed a new algorithm that can automatically refine the Membrane Detection Probability Maps (MDPM) generated to perform automatic segmentation of electron microscopy (EM) images. To achieve…
Deep learning-based methods have recently demonstrated promising results in deformable image registration for a wide range of medical image analysis tasks. However, existing deep learning-based methods are usually limited to small…
In this paper, we propose a predictive regression model for longitudinal images with missing data based on large deformation diffeomorphic metric mapping (LDDMM) and deep neural networks. Instead of directly predicting image scans, our…
Brain cell structure and function reflect neurodevelopment, plasticity and ageing, and changes can help flag pathological processes such as neurodegeneration and neuroinflammation. Accurate and quantitative methods to non-invasively…
Effective learning of asymmetric and local features in images and other data observed on multi-dimensional grids is a challenging objective critical for a wide range of image processing applications involving biomedical and natural images.…
For domains that are easily represented by structured meshes, robust geometric multigrid solvers can quickly provide the numerical solution to many discretized elliptic PDEs. However, for complicated domains with unstructured meshes,…
This study investigates the application of Riemannian geometry-based methods for brain decoding using invasive electrophysiological recordings. Although previously employed in non-invasive, the utility of Riemannian geometry for invasive…
In recent years there has been considerable interest in methods for diffeomorphic warping of images, with applications e.g.\ in medical imaging and evolutionary biology. The original work generally cited is that of the evolutionary…
Manifolds discovered by machine learning models provide a compact representation of the underlying data. Geodesics on these manifolds define locally length-minimising curves and provide a notion of distance, which are key for reduced-order…
We introduce a differential visual similarity metric to train deep neural networks for 3D reconstruction, aimed at improving reconstruction quality. The metric compares two 3D shapes by measuring distances between multi-view images…
State-space models (SSMs) have become a cornerstone for unraveling brain dynamics, revealing how latent neural states evolve over time and give rise to observed signals. By combining the flexibility of deep learning with the principled…