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As a contribution to interpretable machine learning research, we develop a novel optimization framework for learning accurate and sparse two-level Boolean rules. We consider rules in both conjunctive normal form (AND-of-ORs) and disjunctive…

Machine Learning · Statistics 2016-06-21 Guolong Su , Dennis Wei , Kush R. Varshney , Dmitry M. Malioutov

Unsupervised ensemble learning emerged to address the challenge of combining multiple learners' predictions without access to ground truth labels or additional data. This paradigm is crucial in scenarios where evaluating individual…

Machine Learning · Computer Science 2026-01-29 Ariel Maymon , Yanir Buznah , Uri Shaham

Uncertainty quantification in automated image analysis is highly desired in many applications. Typically, machine learning models in classification or segmentation are only developed to provide binary answers; however, quantifying the…

Motivation: Metabolomics data is typically scaled to a common reference like a constant volume of body fluid, a constant creatinine level, or a constant area under the spectrum. Such normalization of the data, however, may affect the…

Ordinary differential equation models have become a standard tool for the mechanistic description of biochemical processes. If parameters are inferred from experimental data, such mechanistic models can provide accurate predictions about…

Quantitative Methods · Quantitative Biology 2018-10-12 Fabian Fröhlich , Carolin Loos , Jan Hasenauer

In todays world the request for very complex models for huge data sets is rising steadily. The problem with these models is that by raising the complexity of the models, it gets much harder to interpret them. The growing field of…

Machine Learning · Statistics 2020-09-18 Alexander Gerharz , Andreas Groll , Gunther Schauberger

In this paper ensemble learning based feature selection and classifier ensemble model is proposed to improve classification accuracy. The hypothesis is that good feature sets contain features that are highly correlated with the class from…

Machine Learning · Computer Science 2020-10-28 Tipawan Silwattananusarn , Wanida Kanarkard , Kulthida Tuamsuk

In the integrative analyses of omics data, it is often of interest to extract data representation from one data type that best reflect its relations with another data type. This task is traditionally fulfilled by linear methods such as…

Applications · Statistics 2021-03-30 Tianwei Yu

Ensemble models refer to methods that combine a typically large number of classifiers into a compound prediction. The output of an ensemble method is the result of fitting a base-learning algorithm to a given data set, and obtaining diverse…

Machine Learning · Statistics 2019-06-10 Waldyn Martinez

We present a novel method - LIBRE - to learn an interpretable classifier, which materializes as a set of Boolean rules. LIBRE uses an ensemble of bottom-up weak learners operating on a random subset of features, which allows for the…

Machine Learning · Computer Science 2019-11-18 Graziano Mita , Paolo Papotti , Maurizio Filippone , Pietro Michiardi

In this paper, we address an issue of finding explainable clusters of class-uniform data in labelled datasets. The issue falls into the domain of interpretable supervised clustering. Unlike traditional clustering, supervised clustering aims…

Machine Learning · Computer Science 2023-07-18 Natallia Kokash , Leonid Makhnist

Interpretability is essential in medical imaging to ensure that clinicians can comprehend and trust artificial intelligence models. In this paper, we propose a novel interpretable approach that combines attribute regularization of the…

Image and Video Processing · Electrical Eng. & Systems 2023-12-15 Maxime Di Folco , Cosmin I. Bercea , Julia A. Schnabel

Connectivity estimation is challenging in the context of high-dimensional data. A useful preprocessing step is to group variables into clusters, however, it is not always clear how to do so from the perspective of connectivity estimation.…

Machine Learning · Statistics 2018-05-25 Ricardo Pio Monti , Aapo Hyvärinen

Recent years have seen important advances in the building of interpretable models, machine learning models that are designed to be easily understood by humans. In this work, we show that large language models (LLMs) are remarkably good at…

Machine Learning · Computer Science 2024-02-23 Sebastian Bordt , Ben Lengerich , Harsha Nori , Rich Caruana

One of the most tedious tasks in the application of machine learning is model selection, i.e. hyperparameter selection. Fortunately, recent progress has been made in the automation of this process, through the use of sequential model-based…

Machine Learning · Computer Science 2014-02-05 Alexandre Lacoste , Hugo Larochelle , François Laviolette , Mario Marchand

Integrating multi-omics datasets through data-driven analysis offers a comprehensive understanding of the complex biological processes underlying various diseases, particularly cancer. Graph Neural Networks (GNNs) have recently demonstrated…

Machine Learning · Computer Science 2025-08-11 Jielong Lu , Zhihao Wu , Jiajun Yu , Jiajun Bu , Haishuai Wang

Metabolomic data can potentially enable accurate, non-invasive and low-cost prediction of coronary artery disease. Regression-based analytical approaches however might fail to fully account for interactions between metabolites, rely on a…

Tree ensemble models like random forests and gradient boosting machines are widely used in machine learning due to their excellent predictive performance. However, a high-performance ensemble consisting of a large number of decision trees…

Machine Learning · Statistics 2024-10-28 Zebin Yang , Agus Sudjianto , Xiaoming Li , Aijun Zhang

Ensembles of classifier models typically deliver superior performance and can outperform single classifier models given a dataset and classification task at hand. However, the gain in performance comes together with the lack in…

Human-Computer Interaction · Computer Science 2017-10-23 Bruno Schneider , Dominik Jäckle , Florian Stoffel , Alexandra Diehl , Johannes Fuchs , Daniel Keim

In this article, we propose a covariance based method for combining partial data sets in the genotype to phenotype spectrum. In particular, an expectation-maximization algorithm that can be used to combine partially overlapping…

Applications · Statistics 2020-01-13 Deniz Akdemir , Julio Isidro Sanchez