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Immunohistochemistry is a valuable diagnostic tool for cancer pathology. However, it requires specialist labs and equipment, is time-intensive, and is difficult to reproduce. Consequently, a long term aim is to provide a digital method of…

Image and Video Processing · Electrical Eng. & Systems 2022-04-15 Christopher D. Walsh , Joanne Edwards , Robert H. Insall

There is large consent that successful training of deep networks requires many thousand annotated training samples. In this paper, we present a network and training strategy that relies on the strong use of data augmentation to use the…

Computer Vision and Pattern Recognition · Computer Science 2015-05-19 Olaf Ronneberger , Philipp Fischer , Thomas Brox

Histopathological images of tumors contain abundant information about how tumors grow and how they interact with their micro-environment. Better understanding of tissue phenotypes in these images could reveal novel determinants of…

Image and Video Processing · Electrical Eng. & Systems 2021-04-14 Adalberto Claudio Quiros , Roderick Murray-Smith , Ke Yuan

Deep learning is a rapidly developing approach in the field of infrared and visible image fusion. In this context, the use of dense blocks in deep networks significantly improves the utilization of shallow information, and the combination…

Computer Vision and Pattern Recognition · Computer Science 2021-01-27 Yu Fu , Xiao-Jun Wu

Deep learning models that are trained on histopathological images obtained from a single lab and/or scanner give poor inference performance on images obtained from another scanner/lab with a different staining protocol. In recent years,…

Image and Video Processing · Electrical Eng. & Systems 2020-10-07 Harshal Nishar , Nikhil Chavanke , Nitin Singhal

Objective: A new image instance segmentation method is proposed to segment individual glands (instances) in colon histology images. This process is challenging since the glands not only need to be segmented from a complex background, they…

Computer Vision and Pattern Recognition · Computer Science 2017-11-27 Yan Xu , Yang Li , Yipei Wang , Mingyuan Liu , Yubo Fan , Maode Lai , Eric I-Chao Chang

Manually annotating nuclei from the gigapixel Hematoxylin and Eosin (H&E)-stained Whole Slide Images (WSIs) is a laborious and costly task, meaning automated algorithms for cell nuclei instance segmentation and classification could…

Computer Vision and Pattern Recognition · Computer Science 2024-07-29 João D. Nunes , Diana Montezuma , Domingos Oliveira , Tania Pereira , Jaime S. Cardoso

We present a novel method for cell segmentation in microscopy images which is inspired by the Generative Adversarial Neural Network (GAN) approach. Our framework is built on a pair of two competitive artificial neural networks, with a…

Computer Vision and Pattern Recognition · Computer Science 2018-09-14 Assaf Arbelle , Tammy Riklin Raviv

Image-to-image translation is a long-established and a difficult problem in computer vision. In this paper we propose an adversarial based model for image-to-image translation. The regular deep neural-network based methods perform the task…

Computer Vision and Pattern Recognition · Computer Science 2019-01-25 Manan Oza , Himanshu Vaghela , Sudhir Bagul

Purpose: The purpose of this study is to investigate the robustness of a commonly-used convolutional neural network for image segmentation with respect to visually-subtle adversarial perturbations, and suggest new methods to make these…

Image and Video Processing · Electrical Eng. & Systems 2019-08-05 Zheng Liu , Jinnian Zhang , Varun Jog , Po-Ling Loh , Alan B McMillan

Weakly supervised nuclei segmentation is a critical problem for pathological image analysis and greatly benefits the community due to the significant reduction of labeling cost. Adopting point annotations, previous methods mostly rely on…

Image and Video Processing · Electrical Eng. & Systems 2022-02-14 Weizhen Liu , Qian He , Xuming He

In histological pathology, frozen sections are often used for rapid diagnosis during surgeries, as they can be produced within minutes. However, they suffer from artifacts and often lack crucial diagnostic details, particularly within the…

Image and Video Processing · Electrical Eng. & Systems 2024-11-12 Elad Yoshai , Gil Goldinger , Miki Haifler , Natan T. Shaked

Melanoma is the most lethal form of skin cancer, with an increasing incidence rate worldwide. Analyzing histological images of melanoma by localizing and classifying tissues and cell nuclei is considered the gold standard method for…

Computer Vision and Pattern Recognition · Computer Science 2025-09-03 Nima Torbati , Anastasia Meshcheryakova , Ramona Woitek , Sepideh Hatamikia , Diana Mechtcheriakova , Amirreza Mahbod

Convolutional neural networks (CNNs) have achieved state-of-the-art performance for automatic medical image segmentation. However, they have not demonstrated sufficiently accurate and robust results for clinical use. In addition, they are…

Computer Vision and Pattern Recognition · Computer Science 2018-07-23 Guotai Wang , Wenqi Li , Maria A. Zuluaga , Rosalind Pratt , Premal A. Patel , Michael Aertsen , Tom Doel , Anna L. David , Jan Deprest , Sebastien Ourselin , Tom Vercauteren

Multiple instance (MI) learning with a convolutional neural network enables end-to-end training in the presence of weak image-level labels. We propose a new method for aggregating predictions from smaller regions of the image into an…

Computer Vision and Pattern Recognition · Computer Science 2018-06-14 Heather D. Couture , J. S. Marron , Charles M. Perou , Melissa A. Troester , Marc Niethammer

This work is about the semantic segmentation of skin lesion boundary and their attributes using Image-to-Image Translation with Conditional Adversarial Nets. Melanoma is a type of skin cancer that can be cured if detected in time.…

Image and Video Processing · Electrical Eng. & Systems 2021-02-02 Cristian Lazo

Generative Adversarial Networks (GANs) are state of the art for image synthesis. Here, we present dapi2ck, a novel GAN-based approach to synthesize cytokeratin (CK) staining from immunofluorescent (IF) DAPI staining of nuclei in non-small…

Image and Video Processing · Electrical Eng. & Systems 2022-08-18 Felix Jakob Segerer , Katharina Nekolla , Lorenz Rognoni , Ansh Kapil , Markus Schick , Helen Angell , Günter Schmidt

The segmentation of cell nuclei in tissue images stained with the blood dye hematoxylin and eosin (H$\&$E) is essential for various clinical applications and analyses. Due to the complex characteristics of cellular morphology, a large…

Image and Video Processing · Electrical Eng. & Systems 2024-07-26 Ziwei Cui , Jingfeng Yao , Lunbin Zeng , Juan Yang , Wenyu Liu , Xinggang Wang

Virtual immunohistochemistry (IHC) staining from hematoxylin and eosin (H&E) images can accelerate diagnostics by providing preliminary molecular insight directly from routine sections, reducing the need for repeat sectioning when tissue is…

Computer Vision and Pattern Recognition · Computer Science 2026-03-16 Jillur Rahman Saurav , Thuong Le Hoai Pham , Pritam Mukherjee , Paul Yi , Brent A. Orr , Jacob M. Luber

Existing deep learning methods of video recognition usually require a large number of labeled videos for training. But for a new task, videos are often unlabeled and it is also time-consuming and labor-intensive to annotate them. Instead of…

Computer Vision and Pattern Recognition · Computer Science 2018-05-14 Feiwu Yu , Xinxiao Wu , Yuchao Sun , Lixin Duan
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