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A novel functional additive model is proposed which is uniquely modified and constrained to model nonlinear interactions between a treatment indicator and a potentially large number of functional and/or scalar pretreatment covariates. The…

Methodology · Statistics 2021-01-26 Hyung Park , Eva Petkova , Thaddeus Tarpey , R. Todd Ogden

One of the goals of neuroscience is to study interactions between different brain regions during rest and while performing specific cognitive tasks. The Multivariate Bayesian Autoregressive Decomposition (MBMARD) is proposed as an intuitive…

Methodology · Statistics 2023-05-16 Guillermo Granados-Garcia , Raquel Prado , Hernando Ombao

Measures of linear dependence (coherence) and nonlinear dependence (phase synchronization) between any number of multivariate time series are defined. The measures are expressed as the sum of lagged dependence and instantaneous dependence.…

Methodology · Statistics 2007-11-12 Roberto D. Pascual-Marqui

Modern mobile health (mHealth) assessment combines self-reported measures of participants' health experiences with passively collected health behavior data throughout the day. These data are collected across multiple measurement scales,…

Methodology · Statistics 2026-03-13 Debangan Dey , Rahul Ghosal , Kathleen Merikangas , Vadim Zipunnikov

Cross-correlation functions (CCFs) are classical tools for studying lead-lag relationships between paired time series, but they are most often used descriptively rather than inferentially. Motivated by mouse experiments on gut-brain…

Applications · Statistics 2026-04-07 Bhaskar Ray , Tùng Bùi , William Matthew Howe , Srijan Sengupta

Topological data analysis (TDA) approaches are becoming increasingly popular for studying the dependence patterns in multivariate time series data. In particular, various dependence patterns in brain networks may be linked to specific tasks…

Methodology · Statistics 2025-12-08 Anass El Yaagoubi Bourakna , Moo K. Chung , Hernando Ombao

A central focus in survival analysis is examining how covariates influence survival time. These covariate effects are often found to be either time-varying, heterogeneous - such as being specific to patients, treatments, or subgroups - or…

Methodology · Statistics 2025-01-24 Niklas Hagemann , Thomas Kneib , Kathrin Möllenhoff

Multivariate time-series analysis involves extracting informative representations from sequences of multiple interdependent variables, supporting tasks such as forecasting, imputation, and anomaly detection. In real-world scenarios, these…

Machine Learning · Computer Science 2026-05-19 Israel Zexer , Omri Azencot

This study investigates the potential of multimodal data integration, which combines electroencephalogram (EEG) data with sociodemographic characteristics like age, sex, education, and intelligence quotient (IQ), to diagnose mental diseases…

Machine Learning · Computer Science 2025-02-07 Himanshi Singh , Sadhana Tiwari , Sonali Agarwal , Ritesh Chandra , Sanjay Kumar Sonbhadra , Vrijendra Singh

Self-initiated attention shifts play a critical role in voluntary behavior but are difficult to study due to the absence of explicit temporal markers. While previous studies have examined their neural correlates, it remains unclear how…

Signal Processing · Electrical Eng. & Systems 2026-05-19 Yuwen Zeng , Dengzhe Hou , Zhang Zhang , Sai Sun , Yongsong Huang , Chia-huei Tseng , Satoshi Shioiri

Current source density (CSD) power asymmetry, a measure derived from electroencephalography (EEG), is a potential biomarker for major depressive disorder (MDD). Though this measure is functional in nature (defined on the frequency domain),…

Applications · Statistics 2020-12-07 Adam Ciarleglio , Eva Petkova , Ofer Harel

Electroencephalography signals allow to explore the functional activity of the brain cortex in a non-invasive way. However, the analysis of these signals is not straightforward due to the presence of different artifacts and the very low…

Neurons and Cognition · Quantitative Biology 2022-01-24 Nicolás Gallego-Molina , Marco Formoso , Andrés Ortiz , Francisco J. Martínez-Murcia , Juan L. Luque

Modern medicine requires generalised approaches to the synthesis and integration of multimodal data, often at different biological scales, that can be applied to a variety of evidence structures, such as complex disease analyses and…

Quantitative Methods · Quantitative Biology 2019-11-11 Devin Taylor , Simeon Spasov , Pietro Liò

We consider the problem of estimating the difference between two functional undirected graphical models with shared structures. In many applications, data are naturally regarded as high-dimensional random function vectors rather than…

Machine Learning · Statistics 2019-11-19 Boxin Zhao , Y. Samuel Wang , Mladen Kolar

Learning from multi-variate time-series with heterogeneous channel configurations remains a fundamental challenge for deep neural networks, particularly in clinical domains such as intracranial electroencephalography (iEEG), where channel…

Machine Learning · Computer Science 2025-08-26 Francesco Carzaniga , Michael Hersche , Abu Sebastian , Kaspar Schindler , Abbas Rahimi

Recent analyses combining advanced theoretical techniques and high-quality data from thousands of simultaneously recorded neurons provide strong support for the hypothesis that neural dynamics operate near the edge of instability across…

Neurons and Cognition · Quantitative Biology 2024-03-25 Rubén Calvo , Carles Martorell , Guillermo B. Morales , Serena Di Santo , Miguel A. Muñoz

Coherence is a widely used measure to assess linear relationships between time series. However, it fails to capture nonlinear dependencies. To overcome this limitation, this paper introduces the notion of residual spectral density as a…

Statistics Theory · Mathematics 2024-05-21 Yuichi Goto , Xuze Zhang , Benjamin Kedem , Shuo Chen

Studying the flow of information between different areas of the brain can be performed by using the so-called Partial Directed Coherence. This measure is usually evaluated by first identifying a multivariate autoregressive model, and then…

Neurons and Cognition · Quantitative Biology 2013-11-26 Pierre-Olivier Amblard

Attention Deficit Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder in children, characterized by difficulties in attention, hyperactivity, and impulsivity. Early and accurate diagnosis of ADHD is critical for effective…

Signal Processing · Electrical Eng. & Systems 2025-04-08 Md Bayazid Hossain , Md Anwarul Islam Himel , Md Abdur Rahim , Shabbir Mahmood , Abu Saleh Musa Miah , Jungpil Shin

Functional connections in the brain are frequently represented by weighted networks, with nodes representing locations in the brain, and edges representing the strength of connectivity between these locations. One challenge in analyzing…

Applications · Statistics 2022-09-28 Yura Kim , Daniel Kessler , Elizaveta Levina