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Cryo-electron microscopy (cryo-EM) is unique among tools in structural biology in its ability to image large, dynamic protein complexes. Key to this ability is image processing algorithms for heterogeneous cryo-EM reconstruction, including…

Quantitative Methods · Quantitative Biology 2022-11-28 Karsten Kreis , Tim Dockhorn , Zihao Li , Ellen Zhong

Recent advances in materials discovery have been driven by structure-based models, particularly those using crystal graphs. While effective for computational datasets, these models are impractical for real-world applications where atomic…

Machine Learning · Computer Science 2025-07-03 Jithendaraa Subramanian , Linda Hung , Daniel Schweigert , Santosh Suram , Weike Ye

Electromagnetic (EM) imaging is an important tool for non-invasive sensing with low-cost and portable devices. One emerging application is EM stroke imaging, which enables early diagnosis and continuous monitoring of brain strokes.…

Signal Processing · Electrical Eng. & Systems 2025-09-08 Rui Guo , Yi Zhang , Yhonatan Kvich , Tianyao Huang , Maokun Li , Yonina C. Eldar

In differential phase contrast scanning transmission electron microscopy (DPC-STEM), variability in dynamical diffraction resulting from changes in sample thickness and local crystal orientation (due to sample bending) can produce contrast…

Materials Science · Physics 2020-02-06 T. Mawson , A. Nakamura , T. C. Petersen , N. Shibata , H. Sasaki , D. M. Paganin , M. J. Morgan , S. D. Findlay

Scanning transmission electron microscopy (STEM) is a powerful tool to reveal the morphologies and structures of materials, thereby attracting intensive interests from the scientific and industrial communities. The outstanding spatial…

Image and Video Processing · Electrical Eng. & Systems 2024-09-26 Hanlei Zhang , Jincheng Bai , Xiabo Chen , Can Li , Chuanjian Zhong , Jiye Fang , Guangwen Zhou

The classical method of determining the atomic structure of complex molecules by analyzing diffraction patterns is currently undergoing drastic developments. Modern techniques for producing extremely bright and coherent X-ray lasers allow a…

Biomolecules · Quantitative Biology 2015-10-12 Tomas Ekeberg , Stefan Engblom , Jing Liu

One of the key challenges in magnetism remains the determination of the nanoscopic magnetization profile within the volume of thick samples, such as permanent ferromagnets. Thanks to the large penetration depth of neutrons, magnetic…

Mesoscale and Nanoscale Physics · Physics 2020-09-21 Philipp Bender , Jonathan Leliaert , Mathias Bersweiler , Dirk Honecker , Andreas Michels

In this research work, we have demonstrated the application of Mask-RCNN (Regional Convolutional Neural Network), a deep-learning algorithm for computer vision and specifically object detection, to semiconductor defect inspection domain.…

Computer Vision and Pattern Recognition · Computer Science 2022-11-07 Bappaditya Dey , Enrique Dehaerne , Kasem Khalil , Sandip Halder , Philippe Leray , Magdy A. Bayoumi

Single-beam scanning electron microscopes (SEM) are widely used to acquire massive data sets for biomedical study, material analysis, and fabrication inspection. Datasets are typically acquired with uniform acquisition: applying the…

Image and Video Processing · Electrical Eng. & Systems 2021-01-11 Lu Mi , Hao Wang , Yaron Meirovitch , Richard Schalek , Srinivas C. Turaga , Jeff W. Lichtman , Aravinthan D. T. Samuel , Nir Shavit

Medical image segmentation is a critical step in computer-aided diagnosis, and convolutional neural networks are popular segmentation networks nowadays. However, the inherent local operation characteristics make it difficult to focus on the…

Computer Vision and Pattern Recognition · Computer Science 2023-05-18 Fenghe Tang , Jianrui Ding , Lingtao Wang , Min Xian , Chunping Ning

Diffraction is the most common method to solve for unknown or partially known crystal structures. However, it remains a challenge to determine the crystal structure of a new material that may have nanoscale size or heterogeneities. Here we…

With the development of affordable aberration-correctors, analytical scanning transmission electron microscopy (STEM) studies of complex interfaces can now be conducted at high spatial resolution at laboratories worldwide. Energy-dispersive…

Materials Science · Physics 2017-04-10 Steven R. Spurgeon , Yingge Du , Scott A. Chambers

The effectiveness of machine learning in metallographic microstructure segmentation is often constrained by the lack of human-annotated phase masks, particularly for rare or compositionally complex morphologies within the metal alloy. We…

Computer Vision and Pattern Recognition · Computer Science 2025-08-05 Hoang Hai Nam Nguyen , Minh Tien Tran , Hoheok Kim , Ho Won Lee

Scanning Electron Microscopy (SEM) is a widely used tool for nanoparticle characterization, but long-term directional drift can compromise image quality. We present a novel algorithm for post-imaging drift correction in SEM nanoparticle…

Atomic-resolution imaging with scanning transmission electron microscopy is a powerful tool for characterizing the nanoscale structure of materials, in particular features such as defects, local strains, and symmetry-breaking distortions.…

Crystal orientation and strain mapping of an individual curved and asymmetrical core-shell hetero-nanowire is performed based on transmission electron microscopy. It relies on a comprehensive analysis of scanning nanobeam electron…

Materials Science · Physics 2023-01-16 Serhii Kryvyi , Slawomir Kret , Piotr Wojnar

Scanning electron microscopy (SEM), a century-old technique, is today a ubiquitous method of imaging the surface of nanostructures. However, most SEM detectors simply count the number of secondary electrons from a material of interest, and…

The miniaturization of semiconductor devices to the scales where small numbers of dopants can control device properties requires the development of new techniques capable of characterizing their dynamics. Investigating single dopants…

Mesoscale and Nanoscale Physics · Physics 2017-06-28 Mohammad Rashidi , Wyatt Vine , Jacob A. J. Burgess , Marco Taucer , Roshan Achal , Jason L. Pitters , Sebastian Loth , Robert A. Wolkow

Synthesizing realistic and spatially precise anomalies is essential for enhancing the robustness of industrial anomaly detection systems. While recent diffusion-based methods have demonstrated strong capabilities in modeling complex defect…

Computer Vision and Pattern Recognition · Computer Science 2025-12-01 Yanshu Wang , Xichen Xu , Xiaoning Lei , Guoyang Xie

The routine and unique determination of minor phases in microstructures is critical to materials science. In metallurgy alone, applications include alloy and process development and the understanding of degradation in service. We develop a…

Materials Science · Physics 2020-01-22 T. P. McAuliffe , A. Foden , C. Bilsland , D. Daskalaki-Mountanou , D. Dye , T. B. Britton
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