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Cancer survival prediction is important for developing personalized treatments and inducing disease-causing mechanisms. Multi-omics data integration is attracting widespread interest in cancer research for providing information for…

Genomics · Quantitative Biology 2022-07-12 Xing Wu , Qiulian Fang

We explore the use of Vector Quantized Variational AutoEncoder (VQ-VAE) models for large scale image generation. To this end, we scale and enhance the autoregressive priors used in VQ-VAE to generate synthetic samples of much higher…

Machine Learning · Computer Science 2019-06-04 Ali Razavi , Aaron van den Oord , Oriol Vinyals

While unsupervised variational autoencoders (VAE) have become a powerful tool in neuroimage analysis, their application to supervised learning is under-explored. We aim to close this gap by proposing a unified probabilistic model for…

Machine Learning · Computer Science 2019-07-15 Qingyu Zhao , Ehsan Adeli , Nicolas Honnorat , Tuo Leng , Kilian M. Pohl

Estimation of uncertainty in deep learning models is of vital importance, especially in medical imaging, where reliance on inference without taking into account uncertainty could lead to misdiagnosis. Recently, the probabilistic Variational…

Machine Learning · Computer Science 2020-10-20 Haleh Akrami , Anand A. Joshi , Sergul Aydore , Richard M. Leahy

Lung cancer is responsible for 21% of cancer deaths in the UK and five-year survival rates are heavily influenced by the stage the cancer was identified at. Recent studies have demonstrated the capability of AI methods for accurate and…

Computer Vision and Pattern Recognition · Computer Science 2023-11-28 Benjamin Keel , Aaron Quyn , David Jayne , Samuel D. Relton

Disentangled representation learning aims to represent the underlying generative factors of a dataset in a latent representation independently of one another. In our work, we propose a discrete variational autoencoder (VAE) based model…

Computer Vision and Pattern Recognition · Computer Science 2025-11-06 Gulcin Baykal , Melih Kandemir , Gozde Unal

Although semi-supervised variational autoencoder (SemiVAE) works in image classification task, it fails in text classification task if using vanilla LSTM as its decoder. From a perspective of reinforcement learning, it is verified that the…

Computation and Language · Computer Science 2016-11-28 Weidi Xu , Haoze Sun , Chao Deng , Ying Tan

Classical supervised classification tasks search for a nonlinear mapping that maps each encoded feature directly to a probability mass over the labels. Such a learning framework typically lacks the intuition that encoded features from the…

Computer Vision and Pattern Recognition · Computer Science 2020-06-11 Cat P. Le , Yi Zhou , Jie Ding , Vahid Tarokh

Recent state-of-the-art autoencoder based generative models have an encoder-decoder structure and learn a latent representation with a pre-defined distribution that can be sampled from. Implementing the encoder networks of these models in a…

Machine Learning · Computer Science 2020-05-11 D. T. Braithwaite , M. O'Connor , W. B. Kleijn

We present a Split Vector Quantized Variational Autoencoder (SVQ-VAE) architecture using a split vector quantizer for NTTS, as an enhancement to the well-known Variational Autoencoder (VAE) and Vector Quantized Variational Autoencoder…

Sound · Computer Science 2023-09-15 Marek Strong , Jonas Rohnke , Antonio Bonafonte , Mateusz Łajszczak , Trevor Wood

Image generative models can learn the distributions of the training data and consequently generate examples by sampling from these distributions. However, when the training dataset is corrupted with outliers, generative models will likely…

Machine Learning · Computer Science 2022-09-21 Chieh-Hsin Lai , Dongmian Zou , Gilad Lerman

Artificial Intelligence (AI) has the potential to revolutionize diagnosis and segmentation in medical imaging. However, development and clinical implementation face multiple challenges including limited data availability, lack of…

Image and Video Processing · Electrical Eng. & Systems 2025-01-22 Zelong Liu , Andrew Tieu , Nikhil Patel , Georgios Soultanidis , Louisa Deyer , Ying Wang , Sean Huver , Alexander Zhou , Yunhao Mei , Zahi A. Fayad , Timothy Deyer , Xueyan Mei

Motivation: Despite advances in the computational analysis of high-throughput molecular profiling assays (e.g. transcriptomics), a dichotomy exists between methods that are simple and interpretable, and ones that are complex but with lower…

Machine Learning · Computer Science 2023-06-12 Pedro Henrique da Costa Avelar , Min Wu , Sophia Tsoka

Vector-quantized autoencoders deliver high-fidelity latents but suffer inherent flaws: the quantizer is non-differentiable, requires straight-through hacks, and is prone to collapse. We address these issues at the root by replacing VQ with…

Machine Learning · Computer Science 2026-02-24 Hao Lu , Onur C. Koyun , Yongxin Guo , Zhengjie Zhu , Abbas Alili , Metin Nafi Gurcan

In this paper, we seek a clinically-relevant latent code for representing the spectrum of macular disease. Towards this end, we construct retina-VAE, a variational autoencoder-based model that accepts a patient profile vector (pVec) as…

Image and Video Processing · Electrical Eng. & Systems 2019-07-12 Stephen G. Odaibo

In this paper, we introduce a Variational Autoencoder (VAE) based training approach that can compress and decompress cancer pathology slides at a compression ratio of 1:512, which is better than the previously reported state of the art…

While most frontier models still use deterministic frequency-based tokenization algorithms such as byte-pair encoding (BPE), there has been significant recent work to design learned neural tokenizers. However, these schemes generally add to…

Machine Learning · Computer Science 2025-12-29 Theo Datta , Kayla Huang , Sham Kakade , David Brandfonbrener

Understanding the structure of complex, nonstationary, high-dimensional time-evolving signals is a central challenge in scientific data analysis. In many domains, such as speech and biomedical signal processing, the ability to learn…

Machine Learning · Computer Science 2026-01-13 Ioannis Ziogas , Aamna Al Shehhi , Ahsan H. Khandoker , Leontios J. Hadjileontiadis

Recent analysis identified distinct genomic subtypes of lower-grade glioma tumors which are associated with shape features. In this study, we propose a fully automatic way to quantify tumor imaging characteristics using deep learning-based…

Image and Video Processing · Electrical Eng. & Systems 2019-06-11 Mateusz Buda , Ashirbani Saha , Maciej A Mazurowski

We present a novel application of Vector quantised variational autoencoders (VQ-VAEs) to deep 1.28 GHz radio continuum images taken from the MeerKAT Galaxy Cluster Legacy Survey (MGCLS).VQ-VAEs are deep learning models widely used in modern…

Instrumentation and Methods for Astrophysics · Physics 2026-01-21 Fernando L. Ventura , Kshitij Thorat , Anna Bosman , Roger Deane , Christopher Cleghorn
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