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Throughout the course of the SARS-CoV-2 pandemic, genetic variation has contributed to the spread and persistence of the virus. For example, various mutations have allowed SARS-CoV-2 to escape antibody neutralization or to bind more…

Populations and Evolution · Quantitative Biology 2024-03-22 Hong-Li Zeng , Cheng-Long Yang , Bo Jing , John Barton , Erik Aurell

CovID-19 genetics analysis is critical to determine virus type,virus variant and evaluate vaccines. In this paper, SARS-Cov-2 RNA sequence analysis relative to region or territory is investigated. A uniform framework of sequence SVM model…

Quantitative Methods · Quantitative Biology 2021-01-12 Jingwei Liu

The SARS-CoV-2 virus and COVID-19 disease have posed unprecedented and overwhelming demand, challenges and opportunities to domain, model and data driven modeling. This paper provides a comprehensive review of the challenges, tasks,…

Computers and Society · Computer Science 2021-08-05 Longbing Cao , Qing Liu

To address the modality imbalance caused by data heterogeneity, existing multi-modal learning (MML) approaches primarily focus on balancing this difference from the perspective of optimization objectives. However, almost all existing…

Machine Learning · Computer Science 2025-01-06 Zhi-Hao Guan

The rapid proliferation of benchmarks for evaluating large language models (LLMs) has created an urgent need for systematic methods to assess benchmark quality itself. We propose Benchmark^2, a comprehensive framework comprising three…

Nowadays, we are witnessing a wide adoption of Machine learning (ML) models in many safety-critical systems, thanks to recent breakthroughs in deep learning and reinforcement learning. Many people are now interacting with systems based on…

Software Engineering · Computer Science 2018-12-07 Houssem Ben Braiek , Foutse Khomh

Machine learning (ML) models show strong promise for new biomedical prediction tasks, but concerns about trustworthiness have hindered their clinical adoption. In particular, it is often unclear whether a model relies on true clinical cues…

Machine Learning · Computer Science 2026-01-13 Dushan N. Wadduwage , Dineth Jayakody , Leonidas Zimianitis

Background. Forecasting the time of forthcoming pandemic reduces the impact of diseases by taking precautionary steps such as public health messaging and raising the consciousness of doctors. With the continuous and rapid increase in the…

Machine Learning · Statistics 2021-02-12 Muhammad Naeem , Jian Yu , Muhammad Aamir , Sajjad Ahmad Khan , Olayinka Adeleye , Zardad Khan

The outbreak of COVID-19 caused millions of deaths worldwide, and the number of total infections is still rising. It is necessary to identify some potentially effective drugs that can be used to prevent the development of severe symptoms or…

Molecular Networks · Quantitative Biology 2022-09-07 Fan Hu , Jiaxin Jiang , Peng Yin

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has emphasized the importance and challenges of correctly interpreting antibody test results. Identification of positive and negative samples requires a…

Quantitative Methods · Quantitative Biology 2023-04-26 Rayanne A. Luke , Anthony J. Kearsley , Nora Pisanic , Yukari C. Manabe , David L. Thomas , Christopher D. Heaney , Paul N. Patrone

Sequential Monte Carlo methods are a powerful framework for approximating the posterior distribution of a state variable in a sequential manner. They provide an attractive way of analyzing dynamic systems in real-time, taking into account…

Populations and Evolution · Quantitative Biology 2024-08-29 Dhorasso Temfack , Jason Wyse

The rapid evolution and global impact of coronaviruses, notably SARS-CoV-1 and SARS-CoV-2, underscore the importance of understanding their molecular mechanisms in detail. This study focuses on the receptor-binding motif (RBM) within the…

Biological Physics · Physics 2026-03-16 Rafael B. Frigori

Sequential Monte Carlo (SMC) algorithms represent a suite of robust computational methodologies utilized for state estimation and parameter inference within dynamical systems, particularly in real-time or online environments where data…

The integration of machine learning methods into bioinformatics provides particular benefits in identifying how therapeutics effective in one context might have utility in an unknown clinical context or against a novel pathology. We aim to…

Machine Learning · Computer Science 2020-06-29 Semih Cantürk , Aman Singh , Patrick St-Amant , Jason Behrmann

Mutating variants of COVID-19 have been reported across many US states since 2021. In the fight against COVID-19, it has become imperative to study the heterogeneity in the time-varying transmission rates for each variant in the presence of…

Populations and Evolution · Quantitative Biology 2022-05-17 K. D. Olumoyin , A. Q. M. Khaliq , K. M. Furati

The rapid advancement of software development practices has introduced challenges in ensuring quality and efficiency across the software engineering (SE) lifecycle. As SE systems grow in complexity, traditional approaches often fail to…

Software Engineering · Computer Science 2025-08-04 Samah Kansab

COVID-19 pandemic has reshaped our world in a timescale much shorter than what we can understand. Particularities of SARS-CoV-2, such as its persistence in surfaces and the lack of a curative treatment or vaccine against COVID-19, have…

Recognizing subtle historical patterns is central to modeling and forecasting problems in time series analysis. Here we introduce and develop a new approach to quantify deviations in the underlying hidden generators of observed data…

Machine Learning · Statistics 2019-10-09 Yi Huang , Ishanu Chattopadhyay

The COVID-19 pandemic has severely impacted health systems and economies worldwide. Significant global efforts are therefore ongoing to improve vaccine efficacies, optimize vaccine deployment, and develop new antiviral therapies to combat…

Populations and Evolution · Quantitative Biology 2021-12-21 Rajat Desikan , Pranesh Padmanabhan , Andrzej M. Kierzek , Piet H. van der Graaf

High-accurate machine learning (ML) image classifiers cannot guarantee that they will not fail at operation. Thus, their deployment in safety-critical applications such as autonomous vehicles is still an open issue. The use of fault…

Artificial Intelligence · Computer Science 2021-10-05 Raul Sena Ferreira , Jean Arlat , Jeremie Guiochet , Hélène Waeselynck