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Machine learning methods can automate the in silico design of biological sequences, aiming to reduce costs and accelerate medical research. Given the limited access to wet labs, in silico design methods commonly use an oracle model to…

Machine Learning · Computer Science 2025-02-25 Shikha Surana , Nathan Grinsztajn , Timothy Atkinson , Paul Duckworth , Thomas D. Barrett

Genomic surveillance of SARS-CoV-2 has been instrumental in tracking the spread and evolution of the virus during the pandemic. The availability of SARS-CoV-2 molecular sequences isolated from infected individuals, coupled with phylodynamic…

Applications · Statistics 2021-08-31 Lorenzo Cappello , Jaehee Kim , Sifan Liu , Julia A. Palacios

With recent advances in sequencing technology it has become affordable and practical to sequence genomes to very high depth-of-coverage, allowing researchers to discover low-frequency variants in the genome. However, due to the errors in…

Genomics · Quantitative Biology 2021-05-10 Bryce Kille , Yunxi Liu , Nicolae Sapoval , Michael Nute , Lawrence Rauchwerger , Nancy Amato , Todd J. Treangen

Throughout the COVID-19 outbreak, malicious attacks have become more pervasive and damaging than ever. Malicious intruders have been responsible for most cybercrimes committed recently and are the cause for a growing number of cyber…

Cryptography and Security · Computer Science 2020-09-22 Jamil Ispahany , Rafiqul Islam

With the rapid spread of COVID-19 worldwide, viral genomic data is available in the order of millions of sequences on public databases such as GISAID. This Big Data creates a unique opportunity for analysis towards the research of effective…

Machine Learning · Computer Science 2022-10-14 Sarwan Ali , Babatunde Bello , Zahra Tayebi , Murray Patterson

Effective property prediction methods can help accelerate the search for COVID-19 antivirals either through accurate in-silico screens or by effectively guiding on-going at-scale experimental efforts. However, existing prediction tools have…

Quantitative Methods · Quantitative Biology 2020-05-08 Wengong Jin , Regina Barzilay , Tommi Jaakkola

Machine Learning is transforming medical research by improving diagnostic accuracy and personalizing treatments. General ML models trained on large datasets identify broad patterns across populations, but their effectiveness is often…

Machine Learning · Computer Science 2024-12-24 Gideon Vos , Liza van Eijk , Zoltan Sarnyai , Mostafa Rahimi Azghadi

Machine learning and deep learning play vital roles in predicting diseases in the medical field. Machine learning algorithms are widely classified as supervised, unsupervised, and reinforcement learning. This paper contains a detailed…

Machine Learning · Computer Science 2023-01-27 D. Kamelesun , R. Saranya , P. Kathiravan

Motivation: Computational methods are essential to extract actionable information from raw sequencing data, and to thus fulfill the promise of next-generation sequencing technology. Unfortunately, computational tools developed to call…

Predictive modelling is vital to guide preventive efforts. Whilst large-scale prospective cohort studies and a diverse toolkit of available machine learning (ML) algorithms have facilitated such survival task efforts, choosing the…

Self-supervised learning (SSL) has emerged as a promising paradigm in medical imaging, addressing the chronic challenge of limited labeled data in healthcare settings. While SSL has shown impressive results, existing studies in the medical…

Computer Vision and Pattern Recognition · Computer Science 2025-07-29 Valay Bundele , Karahan Sarıtaş , Bora Kargi , Oğuz Ata Çal , Kıvanç Tezören , Zohreh Ghaderi , Hendrik Lensch

The pharmaceutical Research and development (R&D) process is lengthy and costly, taking nearly a decade to bring a new drug to the market. However, advancements in biotechnology, computational methods, and machine learning algorithms have…

Biomolecules · Quantitative Biology 2024-01-24 Damilola Oshunyinka

Neural network models have become the leading solution for a large variety of tasks, such as classification, language processing, protein folding, and others. However, their reliability is heavily plagued by adversarial inputs: small input…

Machine Learning · Computer Science 2022-10-04 Natan Levy , Guy Katz

Significantly higher transmissibility of SARS CoV-2 (2019) compared to SARS CoV (2003) can be attributed to mutations of structural proteins (Spike S, Nucleocapsid N, Membrane M, and Envelope E) and the role played by non-structural…

Other Quantitative Biology · Quantitative Biology 2022-12-02 Raju Hazari , Parimal Pal Chaudhuri

Despite of the fast development of highly effective vaccines to control the current COVID$-$19 pandemic, the unequal distribution and availability of these vaccines worldwide and the number of people infected in the world lead to the…

The COVID-19 pandemic, caused by SARS-CoV-2, highlighted the critical need for accurate prediction of disease severity to optimize healthcare resource allocation and patient management. The spike protein, which facilitates viral entry into…

Machine Learning · Computer Science 2025-06-02 Caio Cheohen , Vinnícius M. S. Gomes , Manuela L. da Silva

Crafting adversarial examples has become an important technique to evaluate the robustness of deep neural networks (DNNs). However, most existing works focus on attacking the image classification problem since its input space is continuous…

Machine Learning · Computer Science 2020-04-22 Minhao Cheng , Jinfeng Yi , Pin-Yu Chen , Huan Zhang , Cho-Jui Hsieh

Machine learning (ML) is poised to drive innovations in clinical microbiomics, such as in disease diagnostics and prognostics. However, the successful implementation of ML in these domains necessitates the development of reproducible,…

Genomics · Quantitative Biology 2024-12-02 Natasha K. Dudek , Mariam Chakhvadze , Saba Kobakhidze , Omar Kantidze , Yuriy Gankin

As machine-learning (ML) based systems for malware detection become more prevalent, it becomes necessary to quantify the benefits compared to the more traditional anti-virus (AV) systems widely used today. It is not practical to build an…

Cryptography and Security · Computer Science 2018-06-14 William Fleshman , Edward Raff , Richard Zak , Mark McLean , Charles Nicholas

The growing complexity of Cyber-Physical Systems (CPS) and challenges in ensuring safety and security have led to the increasing use of deep learning methods for accurate and scalable anomaly detection. However, machine learning (ML) models…

Machine Learning · Computer Science 2022-05-04 Xugui Zhou , Maxfield Kouzel , Homa Alemzadeh