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Recent advances in self-supervised deep learning have improved our ability to quantify cellular morphological changes in high-throughput microscopy screens, a process known as morphological profiling. However, most current methods only…

Machine Learning · Computer Science 2026-05-18 Yemin Yu , Emre Hayir , Neil Tenenholtz , Lester Mackey , Ying Wei , David Alvarez-Melis , Ava P. Amini , Alex X. Lu

Cryo-electron microscopy (cryo-EM), the subject of the 2017 Nobel Prize in Chemistry, is a technology for determining the 3-D structure of macromolecules from many noisy 2-D projections of instances of these macromolecules, whose…

Computer Vision and Pattern Recognition · Computer Science 2020-04-22 Roy R. Lederman , Joakim Andén , Amit Singer

The need for clear, trustworthy explanations of deep learning model predictions is essential for high-criticality fields, such as medicine and biometric identification. Class Activation Maps (CAMs) are an increasingly popular category of…

Computer Vision and Pattern Recognition · Computer Science 2023-08-01 Emily Kaczmarek , Olivier X. Miguel , Alexa C. Bowie , Robin Ducharme , Alysha L. J. Dingwall-Harvey , Steven Hawken , Christine M. Armour , Mark C. Walker , Kevin Dick

Depth estimation from monocular endoscopic images presents significant challenges due to the complexity of endoscopic surgery, such as irregular shapes of human soft tissues, as well as variations in lighting conditions. Existing methods…

Image and Video Processing · Electrical Eng. & Systems 2025-02-07 Dawei Lu , Deqiang Xiao , Danni Ai , Jingfan Fan , Tianyu Fu , Yucong Lin , Hong Song , Xujiong Ye , Lei Zhang , Jian Yang

Despite more than 100 years of study, it is unclear if the movement of proteins inside the cell is best described as a mosh pit or an exquisitely choreographed dance. Recent studies suggest the latter. Local interactions induce molecular…

Quantitative Methods · Quantitative Biology 2023-08-25 James A. Galbraith , Catherine G. Galbraith

The Entity Set Expansion (ESE) task aims to expand a handful of seed entities with new entities belonging to the same semantic class. Conventional ESE methods are based on mono-modality (i.e., literal modality), which struggle to deal with…

Computation and Language · Computer Science 2023-07-28 Yangning Li , Tingwei Lu , Yinghui Li , Tianyu Yu , Shulin Huang , Hai-Tao Zheng , Rui Zhang , Jun Yuan

Query embedding (QE) -- which aims to embed entities and first-order logical (FOL) queries in low-dimensional spaces -- has shown great power in multi-hop reasoning over knowledge graphs. Recently, embedding entities and queries with…

Artificial Intelligence · Computer Science 2021-12-23 Zhanqiu Zhang , Jie Wang , Jiajun Chen , Shuiwang Ji , Feng Wu

In cryo-electron microscopy (EM), molecular structures are determined from large numbers of projection images of individual particles. To harness the full power of this single-molecule information, we use the Bayesian inference of EM…

Biomolecules · Quantitative Biology 2018-01-17 Pilar Cossio , David Rohr , Fabio Baruffa , Markus Rampp , Volker Lindenstruth , Gerhard Hummer

The significant morphological and distributional variability among subcellular components poses a long-standing challenge for learning-based organelle segmentation models, significantly increasing the risk of biased feature learning.…

Computer Vision and Pattern Recognition · Computer Science 2025-07-24 Bo Fang , Jianan Fan , Dongnan Liu , Hang Chang , Gerald J. Shami , Filip Braet , Weidong Cai

Semantic segmentation is a computer vision task that associates a label with each pixel in an image. Modern approaches tend to introduce class embeddings into semantic segmentation for deeply utilizing category semantics, and regard…

Computer Vision and Pattern Recognition · Computer Science 2023-08-25 Yuhe Liu , Chuanjian Liu , Kai Han , Quan Tang , Zengchang Qin

Recent advances in single cell sequencing and multi-omics techniques have significantly improved our understanding of biological phenomena and our capacity to model them. Despite combined capture of data modalities showing similar progress,…

Molecular Networks · Quantitative Biology 2025-03-13 Marcello Barylli , Joyaditya Saha , Tineke E. Buffart , Jan Koster , Kristiaan J. Lenos , Louis Vermeulen , Vivek M. Sheraton

Text-based person retrieval aims to identify specific individuals within an image database using textual descriptions. Due to the high cost of annotation and privacy protection, researchers resort to synthesized data for the paradigm of…

Computer Vision and Pattern Recognition · Computer Science 2025-04-29 Hang Yu , Jiahao Wen , Zhedong Zheng

With the accumulation of big data of CME observations by coronagraphs, automatic detection and tracking of CMEs has proven to be crucial. The excellent performance of convolutional neural network in image classification, object detection…

Solar and Stellar Astrophysics · Physics 2019-09-25 Pengyu Wang , Yan Zhang , Li Feng , Hanqing Yuan , Yuan Gan , Shuting Li , Lei Lu , Beili Ying , Weiqun Gan , Hui Li

Coreset selection methods are effective in accelerating training and reducing memory requirements but remain largely unexplored in applied multimodal settings. We adapt a state-of-the-art (SoTA) coreset selection technique for multimodal…

Machine Learning · Computer Science 2025-02-25 Viktor Moskvoretskii , Narek Alvandian

Paired single-cell sequencing technologies enable the simultaneous measurement of complementary modalities of molecular data at single-cell resolution. Along with the advances in these technologies, many methods based on variational…

Multi-modal entity alignment (MMEA) aims to identify equivalent entities between two multi-modal knowledge graphs for integration. Unfortunately, prior arts have attempted to improve the interaction and fusion of multi-modal information,…

Machine Learning · Computer Science 2024-03-05 Luyao Wang , Pengnian Qi , Xigang Bao , Chunlai Zhou , Biao Qin

The segmentation of cell nuclei in tissue images stained with the blood dye hematoxylin and eosin (H$\&$E) is essential for various clinical applications and analyses. Due to the complex characteristics of cellular morphology, a large…

Image and Video Processing · Electrical Eng. & Systems 2024-07-26 Ziwei Cui , Jingfeng Yao , Lunbin Zeng , Juan Yang , Wenyu Liu , Xinggang Wang

Estimating rigid objects' poses is one of the fundamental problems in computer vision, with a range of applications across automation and augmented reality. Most existing approaches adopt one network per object class strategy, depend…

Computer Vision and Pattern Recognition · Computer Science 2024-10-14 Jianyu Zhao , Wei Quan , Bogdan J. Matuszewski

Recent developments in single-cell omics technologies have enabled the quantification of molecular profiles in individual cells at an unparalleled resolution. Deep learning, a rapidly evolving sub-field of machine learning, has instilled a…

Genomics · Quantitative Biology 2024-01-17 Manoj M Wagle , Siqu Long , Carissa Chen , Chunlei Liu , Pengyi Yang

Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) derived from somatic cells (SCs) provide promising resources for regenerative medicine and medical research, leading to a daily identification of new cell lines.…

Quantitative Methods · Quantitative Biology 2013-02-15 Anyou Wang
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