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Purpose: Recent developments in computational pathology have been driven by advances in Vision Foundation Models, particularly the Segment Anything Model (SAM). This model facilitates nuclei segmentation through two primary methods:…

Computer Vision and Pattern Recognition · Computer Science 2025-08-22 Xueyuan Li , Can Cui , Ruining Deng , Yucheng Tang , Quan Liu , Tianyuan Yao , Shunxing Bao , Naweed Chowdhury , Haichun Yang , Yuankai Huo

Universal multimodal embedding models have achieved great success in capturing semantic relevance between queries and candidates. However, current methods either condense queries and candidates into a single vector, potentially limiting the…

Information Retrieval · Computer Science 2026-04-08 Zilin Xiao , Qi Ma , Mengting Gu , Chun-cheng Jason Chen , Xintao Chen , Vicente Ordonez , Vijai Mohan

Numerical investigation of the interaction of electromagnetic fields with eukaryotic cells requires specifically adapted computer models. Virtual microdosimetry, used to investigate exposure, requires volumetric cell models, which are…

Data-driven design of mechanical metamaterials is an increasingly popular method to combat costly physical simulations and immense, often intractable, geometrical design spaces. Using a precomputed dataset of unit cells, a multiscale…

Computational Engineering, Finance, and Science · Computer Science 2021-12-08 Yu-Chin Chan , Faez Ahmed , Liwei Wang , Wei Chen

In the integrative analyses of omics data, it is often of interest to extract data representation from one data type that best reflect its relations with another data type. This task is traditionally fulfilled by linear methods such as…

Applications · Statistics 2021-03-30 Tianwei Yu

This work contributes to breast cancer sub-type classification using histopathological images. We utilize masked autoencoders (MAEs) to learn a self-supervised embedding tailored for computer vision tasks in this domain. This embedding…

Computer Vision and Pattern Recognition · Computer Science 2025-06-10 Annalisa Chiocchetti , Marco Dossena , Christopher Irwin , Luigi Portinale

This research aims to develop a dynamic and scalable framework to facilitate harmonization of Common Data Elements (CDEs) across heterogeneous biomedical datasets by addressing challenges such as semantic heterogeneity, structural…

Information Retrieval · Computer Science 2025-06-04 Madan Krishnamurthy , Daniel Korn , Melissa A Haendel , Christopher J Mungall , Anne E Thessen

Single-cell sequencing technology maps cells to a high-dimensional space encoding their internal activity. Recently-proposed virtual cell models extend this concept, enriching cells' representations based on patterns learned from…

Quantitative Methods · Quantitative Biology 2025-11-03 William Gilpin

There are a wide range of applications that involve multi-modal data, such as cross-modal retrieval, visual question-answering, and image captioning. Such applications are primarily dependent on aligned distributions of the different…

Machine Learning · Computer Science 2020-05-26 Vishaal Udandarao , Abhishek Maiti , Deepak Srivatsav , Suryatej Reddy Vyalla , Yifang Yin , Rajiv Ratn Shah

*To be published in Springer Handbook of Surface Science (Springer Verlag) [Preprint]* The capability to display images containing chemical, magnetic and structural information and to perform spectroscopy and diffraction from a {\mu}m-sized…

Mesoscale and Nanoscale Physics · Physics 2018-12-06 Alessandro Sala

Probes are small networks that predict properties of underlying data from embeddings, and they provide a targeted, effective way to illuminate the information contained in embeddings. While analysis through the use of probes has become…

Cell segmentation in histopathological images is vital for diagnosis, and treatment of several diseases. Annotating data is tedious, and requires medical expertise, making it difficult to employ supervised learning. Instead, we study a…

Computer Vision and Pattern Recognition · Computer Science 2025-11-06 Aayush Kumar Tyagi , Vaibhav Mishra , Prathosh A. P. , Mausam

Modeling the relationship between chemical structure and molecular activity is a key goal in drug development. Many benchmark tasks have been proposed for molecular property prediction, but these tasks are generally aimed at specific,…

Quantitative Methods · Quantitative Biology 2020-10-05 Samuel G. Finlayson , Matthew B. A. McDermott , Alex V. Pickering , Scott L. Lipnick , Isaac S. Kohane

Comparing and aligning large datasets is a pervasive problem occurring across many different knowledge domains. We introduce and study MREC, a recursive decomposition algorithm for computing matchings between data sets. The basic idea is to…

Machine Learning · Statistics 2020-02-24 Andrew J. Blumberg , Mathieu Carriere , Michael A. Mandell , Raul Rabadan , Soledad Villar

Melanoma is a fatal skin cancer that is curable and has dramatically increasing survival rate when diagnosed at early stages. Learning-based methods hold significant promise for the detection of melanoma from dermoscopic images. However,…

Image and Video Processing · Electrical Eng. & Systems 2022-04-06 Saban Ozturk , Tolga Cukur

Constant envelope (CE) precoding design is of great interest for massive multiuser multi-input multi-output systems because it can significantly reduce hardware cost and power consumption. However, existing CE precoding algorithms are…

Signal Processing · Electrical Eng. & Systems 2020-06-30 Yunfeng He , Hengtao , He , Chao-Kai Wen , Shi Jin

Deep clustering methods typically rely on a single, well-defined representation for clustering. In contrast, pretrained diffusion models provide abundant and diverse multi-scale representations across network layers and noise timesteps.…

Machine Learning · Computer Science 2026-01-22 Haidong Hu , Xiaoyu Zheng , Jin Zhou , Yingxu Wang , Rui Wang , Pei Dong , Shiyuan Han , Lin Wang , C. L. Philip Chen , Tong Zhang , Yuehui Chen

Antibody binding site prediction plays a pivotal role in computational immunology and therapeutic antibody design. Existing sequence or structure methods rely on single-view features and fail to identify antibody-specific binding sites on…

Machine Learning · Computer Science 2025-09-12 Hongzong Li , Jiahao Ma , Zhanpeng Shi , Rui Xiao , Fanming Jin , Ye-Fan Hu , Hangjun Che , Jian-Dong Huang

While Electrical Impedance Tomography (EIT) has found many biomedicine applications, a better resolution is needed to provide quantitative analysis for tissue engineering and regenerative medicine. This paper proposes an impedance-optical…

Image and Video Processing · Electrical Eng. & Systems 2021-12-09 Zhe Liu , Pierre Bagnaninchi , Yunjie Yang

The living body is composed of innumerable fine and complex structures and although these structures have been studied in the past, a vast amount of information pertaining to them still remains unknown. When attempting to observe these…

Medical Physics · Physics 2021-11-30 Raku Son , Kenji Yamazawa , Akiko Oguchi , Mitsuo Suga , Masaru Tamura , Yasuhiro Murakawa , Satoshi Kume
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