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Droplet microlasers, as promising tools for biophotonics and biomedical sciences, have witnessed rapid advances due to their flexible reconfigurability, high sensitivity to stimuli, and label-free biosensing ability. However, designing…

Our growing ability to tailor healthcare to the needs of individuals has the potential to transform clinical treatment. However, the measurement of multiple biomarkers to inform clinical decisions requires rapid, effective, and affordable…

Biosensors are an essential tool for medical diagnostics, environmental monitoring and food safety. Typically, biosensors are designed to detect specific analytes through functionalization with the appropriate capture agents. However, the…

Medical Physics · Physics 2023-09-26 Simon J. Ward , Tengfei Cao , Xiang Zhou , Catie Chang , Sharon M. Weiss

A low-power wearable wireless sensor measuring both molecular biomarkers and physiological signals is proposed, where the former are measured by a microfluidic biosensing system while the latter are measured electrically. The low-power…

Signal Processing · Electrical Eng. & Systems 2019-07-04 Xueyuan Zhao , Vidyasagar Sadhu , Tuan Le , Dario Pompili , Mehdi Javanmard

Biosensors are essential tools which have been traditionally used to monitor environmental pollution, detect the presence of toxic elements and biohazardous bacteria or virus in organic matter and biomolecules for clinical diagnostics. In…

Chemical Physics · Physics 2021-01-08 Aishwaryadev Banerjee , Swagata Maity , Carlos H. Mastrangelo

Clinical biosensors with low detection limit hold significant promise in the early diagnosis of debilitating diseases. Recent progress in sensor development has led to the demonstration of detection capable of detecting target molecules…

Medical Physics · Physics 2019-12-05 Tuhin Chakrabortty , Chandra R. Murthy , Manoj Varma

Advances in methods of biological data collection are driving the rapid growth of comprehensive datasets across clinical and research settings. These datasets provide the opportunity to monitor biological systems in greater depth and at…

Molecular Networks · Quantitative Biology 2025-01-20 Joshua Pickard , Cooper Stansbury , Amit Surana , Lindsey Muir , Anthony Bloch , Indika Rajapakse

Decentralized diagnostic testing that is accurate, portable, quantitative, and capable of making multiple simultaneous measurements of different biomarkers at the point-of-need remains an important unmet need in the post-pandemic world.…

Electronic biosensors are a natural fit for field-deployable diagnostic devices, because they can be miniaturized, mass produced, and integrated with circuitry. Unfortunately, progress in the development of such platforms has been hindered…

Applied Physics · Physics 2020-07-28 Vladimir Kesler , Boris Murmann , H. Tom Soh

Due to the absence of labels and fast analyses, optical biosensors promise major advances in biomedical diagnostics, security, environmental and food safety applications. However, sensitivity of the most advanced plasmonic biosensor…

Biolasers made of biological materials have attracted a great of research attention due to their biocompatibility and biodegradability, which have the potential for biosensors and biointegration. However, the current fabrication method of…

The recent development of drugs able to mitigate neurodegenerative diseases has created an urgent need for novel diagnostics. Although biomarker detection directly in patients' blood is now possible, low-cost point-of-care tests remain a…

Single-molecule fluorescence techniques provide exceptional sensitivity to probe biomolecular interactions. However, their application to accurately quantify analytes at the picomolar concentrations relevant for biosensing remains…

Optics · Physics 2025-02-18 Malavika Kayyil Veedu , Jérôme Wenger

One of the most important processes in the fight against current and future pandemics is the rapid diagnosis and initiation of treatment of viruses in humans. In these times, the development of high-sensitivity tests and diagnostic kits is…

Optics · Physics 2022-12-13 Junfei Wang , Zhenyu Xu , Domna G. Kotsifaki

Physical limit of molecular sensing has been extensively studied in biological systems. Biosensors are engineered equivalents of molecular sensors in living systems and play critical role in disease diagnosis and management. Investigation…

Biological Physics · Physics 2021-08-10 Tuhin Chakrabortty , Manoj M Varma

Considerable attention has been directed towards the prognosis of lung diseases primarily due to their high prevalence. Despite advancements in detection technologies, current methods such as computed tomography, chest radiographs, bold…

Materials Science · Physics 2025-02-25 Sudipta Saha , Md. Kawsar Alam

Detection of small cancer biomarkers with low molecular weight and a low concentration range has always been challenging yet urgent in many clinical applications such as diagnosing early-stage cancer, monitoring treatment and detecting…

The mechanical properties of biological fluids can serve as early indicators of disease, offering valuable insights into complex physiological and pathological processes. However, the existing technologies can hardly support high throughput…

Optics · Physics 2025-09-18 Zhonghao Li , Zhihan Cai , Chaoyang Gong

Sensing biological forces with microscopic lasers is an emerging technique that offers significant advantages over conventional fluorescent probes and imaging-based techniques. However, the limited availability of suitable deformable or…

Optics · Physics 2026-04-13 Melisa A. Bayrak , David Ripp , Joseph S. Hill , Marcel Schubert

Optical biosensors based on micro-/nano-fibers are highly valuable for probing and monitoring liquid environments and bioactivity. Most of current optical biosensors, however, are still based on glass, semiconductors, or metallic materials,…

Optics · Physics 2025-02-27 X. Yang , L. Xu , S. Xiong , H. Rao , F. Tan , J. Yan , Y. Bao , A. Albanese , A. Camposeo , D. Pisignano , B. Li
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