Related papers: Patient-specific modelling, simulation and real-ti…
Cardio-pulmonary arrest is a common emergency situation causing over 400,000 deaths per year, more than a 1000 per day, in the USA alone. The goal of this work is to develop an agent based computer simulator that will allow trainers to…
The onset of old age brings physiological and mental changes, with anxiety and depression being common mental disorders that can trigger other health issues and reduce lifespan. However, due to a global shortage of mental health…
Pulmonary diseases impact millions of lives globally and annually. The recent outbreak of the pandemic of the COVID-19, a novel pulmonary infection, has more than ever brought the attention of the research community to the machine-aided…
The purpose of this study is to provide means to physicians for automated and fast recognition of airways diseases. In this work, we mainly focus on measures that can be easily recorded using a spirometer. The signals used in this framework…
The European Union's climate targets challenge the building sector to reduce energy use while ensuring comfort. Ventilation systems play an important role in achieving these goals. During system planning, the primary focus tends to lie on…
For many complex diseases, there is a wide variety of ways in which an individual can manifest the disease. The challenge of personalized medicine is to develop tools that can accurately predict the trajectory of an individual's disease,…
We propose a stochastic individual-based model of the progression of atrial fibrillation (AF). The model operates at patient level over a lifetime and is based on elements of the physiology and biophysics of AF, making contact with existing…
As populations age, the rise of multimorbidity poses a significant healthcare challenge. However, our ability to quantitatively forecast the progression of multimorbidity remains limited. Leveraging a nationwide dataset comprising…
Hospital readmissions are expensive and reflect the inadequacies in healthcare system. In the United States alone, treatment of readmitted diabetic patients exceeds 250 million dollars per year. Early identification of patients facing a…
Disease management programs have emerged as a cost-effective approach to treat chronic diseases. Appointment adherence is critical to the success of such programs; missed appointment are costly, resulting in reduced resource utilization and…
The complexity of mathematical models describing respiratory mechanics has grown in recent years, however, parameter identifiability of such models has only been studied in the last decade in the context of observable data. This study…
The increase in cardiac and pulmonary diseases presents an alarming and pervasive health challenge on a global scale responsible for unexpected and premature mortalities. In spite of how serious these conditions are, existing methods of…
Stroke is a major cause of mortality and long--term disability in the world. Predictive outcome models in stroke are valuable for personalized treatment, rehabilitation planning and in controlled clinical trials. In this paper we design a…
Respiratory diseases remain a leading cause of mortality worldwide, highlighting the need for faster and more accurate diagnostic tools. This work presents a novel approach leveraging digital stethoscope technology for automatic respiratory…
Chronic obstructive pulmonary disease (COPD) causes lung inflammation and airflow blockage leading to a variety of respiratory symptoms; it is also a leading cause of death and affects millions of individuals around the world. Patients…
With a mortality rate of 5.4 million lives worldwide every year and a healthcare cost of more than 16 billion dollars in the USA alone, sepsis is one of the leading causes of hospital mortality and an increasing concern in the ageing…
The seemingly simple process of inhalation relies on a complex interplay between muscular contraction in the thorax, elasto-capillary interactions in individual lung branches, propagation of air between different connected branches, and…
Background: Obstructive sleep apnea (OSA) is growing increasingly prevalent in many countries as obesity rises. Sufficient, effective treatment of OSA entails high social and financial costs for healthcare. Objective: For treatment…
Smoking is one of the main risk factors that has affected human mortality and life expectancy over the past century. Smoking accounts for a large part of the nonlinearities in the growth of life expectancy and of the geographic and sex…
Radiation therapy of thoracic and abdominal tumors requires incorporating the respiratory motion into treatments. To precisely account for the patient respiratory motions and predict the respiratory signals, a generalized model for…