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In this paper we study a bilinear optimal control problem associated to a chemo-repulsion model with linear production term. We analyze the existence, uniqueness and regularity of pointwise strong solutions in a bidimensional domain. We…

Optimization and Control · Mathematics 2019-01-23 Francisco Guillén González , Exequiel Mallea-Zepeda , María Ángeles Rodríguez-Bellido

In this paper, we study an optimal control problem for a coupled non-linear system of reaction-diffusion equations with degenerate diffusion, consisting of two partial differential equations representing the density of cells and the…

Optimization and Control · Mathematics 2024-07-11 Georges Chamoun , Mazen Saad , Toni Sayah , Sarah Serhal

We consider a bilinear optimal control problem associated to the following chemotaxis-consumption model in a bounded domain $\Omega \subset \mathbb{R}^3$ during a time interval $(0,T)$: $$\partial_t u - \Delta u = - \nabla \cdot (u \nabla…

Optimization and Control · Mathematics 2023-10-26 Francisco Guillén-González , André Luiz Corrêa Vianna Filho

In the present work we investigate an optimal control problem related to the following chemotaxis-consumption model in a bounded domain $\Omega\subset \mathbb{R}^3$: $$\partial_t u - \Delta u = - \nabla \cdot (u \nabla v), \quad \partial_t…

Optimization and Control · Mathematics 2024-02-12 Francisco Guillén-González , André Luiz Corrêa Vianna Filho

In this paper, we consider an optimal bilinear control problem for the nonlinear Schr\"{o}dinger equations with singular potentials. We show well-posedness of the problem and existence of an optimal control. In addition, the first order…

Analysis of PDEs · Mathematics 2013-01-21 Binhua Feng , Dun Zhao , Pengyu Chen

In this work we introduce a new optimal control algorithm for the Keller-Segel chemo-attraction system, where both boundary and distributed controls are considered and both are associated with introducing/removing the amount of chemical…

Optimization and Control · Mathematics 2026-03-20 F. Guillen-Gonzalez , F. Palmero-Ramos , M. A. Rodriguez-Bellido , G. Tierra

In this paper we study the following three-dimensional parabolic-parabolic chemo-repulsion model with potential production, logistic reaction and bilinear control, defined in $Q=(0,T)\times\Omega$: \begin{equation*}\label{eq0} \left\{…

In this work, we will investigate the question of optimal control for bilinear systems with constrained endpoint. The optimal control will be characterized through a set of unconstrained minimization problems that approximate the former.…

Optimization and Control · Mathematics 2021-07-28 Soufiane Yahyaoui , Lahoussine Lafhim , Mohamed Ouzahra

In this paper, we address a distributed control problem for a system of partial differential equations describing the evolution of a tumor that takes the biological mechanism of chemotaxis into account. The system describing the evolution…

Optimization and Control · Mathematics 2023-09-19 Gianni Gilardi , Andrea Signori , Jürgen Sprekels

We study the solutions of the two-dimensional Keller-Segel system describing chemotaxis. The Keller-Segel system as well as the properties of the blow-up set has been extensively studied. In this paper we obtain generalized solutions for…

Analysis of PDEs · Mathematics 2010-11-02 S. Luckhaus , Y. Sugiyama , J. J. L. Velázquez

In this paper we study a bilinear optimal control problem associated to a 3D chemo-repulsion model with linear production. We prove the existence of weak solutions and we establish a regularity criterion to get global in time strong…

Optimization and Control · Mathematics 2018-08-29 Francisco Guillén-González , Exequiel Mallea-Zepeda , María Ángeles Rodríguez-Bellido

The mathematical modeling of numerous real-world applications results in hierarchical optimization problems with two decision makers where at least one of them has to solve an optimal control problem of ordinary or partial differential…

Optimization and Control · Mathematics 2019-06-20 Patrick Mehlitz , Gerd Wachsmuth

In this paper, we study chemotaxis effect vs logistic dampening on boundedness for the two-dimensional minimal Keller-Segel model with logistic source in a 2-D smooth and bounded domain. It is well-known that this model allows only for…

Analysis of PDEs · Mathematics 2018-07-18 Hai-Yang Jin , Tian Xiang

We consider constrained bilinear optimal control of second-order linear evolution partial differential equations (PDEs) with a reaction term on the half line, where control arises as a time-dependent reaction coefficient and constraints are…

Computational Physics · Physics 2025-11-20 Zhexian Li , Felipe de Barros , Ketan Savla

We consider a bilinear optimal control for an evolution equation involving the fractional Laplace operator of order $0<s<1$. We first give some existence and uniqueness results for the considered evolution equation. Next, we establish some…

Optimization and Control · Mathematics 2024-11-26 Gisèle Mophou , Cyrille Kenne , Mahamadi Warma

This paper concerns a distributed optimal control problem for a tumor growth model of Cahn-Hilliard type including chemotaxis with possibly singular potentials, where the control and state variables are nonlinearly coupled. First, we…

Optimization and Control · Mathematics 2023-06-06 Pierluigi Colli , Andrea Signori , Jürgen Sprekels

It is known that in two dimensions the classical Keller-Segel model can lead to cell aggregation. This behavior can be controlled by adding a logistic growth term with quadratic decay. Researchers have tried to find weaker damping…

Analysis of PDEs · Mathematics 2026-03-17 Nohayla Alaoui , Mohamed Halloumi , Giuseppe Viglialoro

This paper investigates an optimal control problem associated with a two-dimensional multi-species Cahn-Hilliard-Keller-Segel tumor growth model, which incorporates complex biological processes such as species diffusion, chemotaxis,…

Analysis of PDEs · Mathematics 2024-07-26 Pierluigi Colli , Gianni Gilardi , Andrea Signori , Jürgen Sprekels

We propose and analyze an optimal control problem associated with a Keller-Segel type parabolic system with chemoattraction, modeling the glioblastoma growth in a bi-dimensional bounded domain, influenced by the presence of oxygen where the…

Optimization and Control · Mathematics 2026-04-24 Juan J. Forero-Hernańdez , Francisco Guillén-González , Élder J. Villamizar-Roa

The Keller-Segel model is a system of partial differential equations that describes the movement of cells or organisms in response to chemical signals, a phenomenon known as chemotaxis. In this study, we analyze a doubly parabolic…

Analysis of PDEs · Mathematics 2025-03-27 Anne Caroline Bronzi , Crystianne Lilian de Andrade
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