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Traditional survival analysis techniques focus on the occurrence of failures over the time. During analysis of such events, ignoring the related unobserved covariates or heterogeneity involved in data sample may leads us to adverse…

Methodology · Statistics 2021-12-22 Shikhar Tyagi , Arvind Pandey , David D Hanagal

This paper compares six different parameter estimation methods for shared frailty models via a series of simulation studies. A shared frailty model is a survival model that incorporates a random effect term, where the frailties are common…

Methodology · Statistics 2023-11-21 Tingxuan Wu , Cindy Feng , Longhai Li

This work presents a new model and estimation procedure for the illness-death survival data where the hazard functions follow accelerated failure time (AFT) models. A shared frailty variate induces positive dependence among failure times of…

Methodology · Statistics 2022-05-10 Lea Kats , Malka Gorfine

In this work we provide a simple estimation procedure for a general frailty model for analysis of prospective correlated failure times. Rigorous large-sample theory for the proposed estimators of both the regression coefficient vector and…

Statistics Theory · Mathematics 2007-06-13 Malka Gorfine , David M. Zucker , Li Hsu

We propose a novel frailty model with change points applying random effects to a Cox proportional hazard model to adjust the heterogeneity between clusters. Because the frailty model includes random effects, the parameters are estimated…

Methodology · Statistics 2023-01-12 Masahiro Kojima , Shunichiro Orihara

The R package frailtySurv for simulating and fitting semi-parametric shared frailty models is introduced. Package frailtySurv implements semi-parametric consistent estimators for a variety of frailty distributions, including gamma,…

Computation · Statistics 2018-09-07 John V. Monaco , Malka Gorfine , Li Hsu

Frailty models are essential tools in survival analysis for addressing unobserved heterogeneity and random effects in the data. These models incorporate a random effect, the frailty, which is assumed to impact the hazard rate…

Statistics Theory · Mathematics 2025-04-01 Jorge Yslas

A novel mixture cure frailty model is introduced for handling censored survival data. Mixture cure models are preferable when the existence of a cured fraction among patients can be assumed. However, such models are heavily underexplored:…

Methodology · Statistics 2025-05-07 Fatih Kızılaslan , David Michael Swanson , Valeria Vitelli

Dependent survival data arise in many contexts. One context is clustered survival data, where survival data are collected on clusters such as families or medical centers. Dependent survival data also arise when multiple survival times are…

Methodology · Statistics 2022-05-12 Malka Gorfine , David M. Zucker

Here, we introduce a new class of Lindley generated distributions which results in more flexible model with increasing failure rate (IFR), decreasing failure rate(DFR) and up-side down hazard functions for different choices of parametric…

Statistics Theory · Mathematics 2016-01-07 Deepesh Bhati , Mohd. Aamir Malik , K. K. Jose

In this paper a new distribution is proposed. This new model provides more flexibility to modeling data with upside-down bathtub hazard rate function. A significant account of mathematical properties of the new distribution is presented.…

Statistics Theory · Mathematics 2017-11-28 Pedro L. Ramos , Francisco Louzada , Taciana K. O. Shimizu , Aline O. Luiz

Shared frailty models have been proposed to accommodate unmeasured cluster-specific risk factors through the inclusion of a common latent frailty term. Among possible frailty distributions, the Gamma distribution is appealing due to its…

Methodology · Statistics 2026-05-13 Piotr Lewczuk , Oswaldo Gressani , Steven Abrams , Christel Faes

In this paper, we proposed a new lifetime distribution namely generalized weighted Lindley (GLW) distribution. The GLW distribution is a useful generalization of the weighted Lindley distribution, which accommodates increasing, decreasing,…

Statistics Theory · Mathematics 2016-07-20 P. L. Ramos , F. Louzada

This paper presents a score-based weighted likelihood estimator (SWLE) for robust estimations of generalized linear model (GLM) for insurance loss data. The SWLE exhibits a limited sensitivity to the outliers, theoretically justifying its…

Methodology · Statistics 2022-04-25 Tsz Chai Fung

A new class of survival frailty models based on the Generalized Inverse-Gaussian (GIG) distributions is proposed. We show that the GIG frailty models are flexible and mathematically convenient like the popular gamma frailty model.…

We introduce a flexible individual frailty model for clustered right-censored data, in which covariate effects can be marginally interpreted as log failure odds ratios. Flexible correlation structures can be imposed by introducing…

Methodology · Statistics 2014-03-27 Rui Zhang Kwun Chuen Gary Chan

This paper considers robust modeling of the survival time for cancer patients. Accurate prediction can be helpful for developing therapeutic and care strategies. We propose a unified Expectation-Maximization approach combined with the…

Methodology · Statistics 2019-12-23 Yi Li , Muxuan Liang , Lu Mao , Sijian Wang

Frailty models are often the model of choice for heterogeneous survival data. A frailty model contains both random effects and fixed effects, with the random effects accommodating for the correlation in the data. Different estimation…

Methodology · Statistics 2019-09-17 Oodally Ajmal , Luc Duchateau , Estelle Kuhn

Current status data abounds in the field of epidemiology and public health, where the only observable data for a subject is the random inspection time and the event status at inspection. Motivated by such a current status data from a…

Methodology · Statistics 2020-04-24 Tong Wang , Kejun He , Wei Ma , Dipankar Bandyopadhyay , Samiran Sinha

Unobserved individual heterogeneity is a common challenge in population cancer survival studies. This heterogeneity is usually associated with the combination of model misspecification and the failure to record truly relevant variables. We…

Methodology · Statistics 2023-01-06 F. J. Rubio , H. Putter , A. Belot
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