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Hyperpolarized 13C-MRI allows real time observation of metabolism in vivo. Imaging sequences have been developed to follow the metabolism of [1-13C] pyruvate and extract reaction kinetics, which can show tumour treatment response. We…

Biomolecules · Quantitative Biology 2018-01-08 Junzhe Zhao

Subject-specific cardiovascular models rely on parameter estimation using measurements such as 4D Flow MRI data. However, acquiring high-resolution, high-fidelity functional flow data is costly and taxing for the patient. As a result, there…

Medical Physics · Physics 2025-12-09 Miriam Löcke , Ahmed Attia , Dariusz Ucínski , Cristóbal Bertoglio

MRI with hyperpolarized (HP) 13C agents, also known as HP 13C MRI, can measure processes such as localized metabolism that is altered in numerous cancers, liver, heart, kidney diseases, and more. It has been translated into human studies…

We study the problem of estimating a parametric discrete memoryless channel \( p(y \mid x; \boldsymbol{\theta}) \) when the transmitter selects its input distribution \( \pi \) to maximize mutual information under the true parameter \(…

Information Theory · Computer Science 2026-05-13 Hassan Tavakoli , Thinh Nguyen , Bella Bose

Purpose: To develop an approach for improving the resolution and sensitivity of hyperpolarized 13C MRSI based on a priori anatomical information derived from featured, water-based 1H images. Methods: A reconstruction algorithm exploiting 1H…

Medical Physics · Physics 2018-11-26 Gil Farkash , Stefan Markovic , Mihajlo Novakovic , Lucio Frydman

Mutual information (MI) is a promising candidate measure for the assessment and optimization of localization systems, as it captures nonlinear dependencies between random variables. However, the high cost of computing MI, especially for…

Signal Processing · Electrical Eng. & Systems 2025-11-04 Sven Hinderer , Manuel Buchfink , Bin Yang

In the context of emerging stacked intelligent metasurface (SIM)-based holographic MIMO (HMIMO) systems, a fundamental problem is to study the mutual information (MI) between transmitted and received signals to establish their capacity.…

Information Theory · Computer Science 2024-08-27 Nemanja Stefan Perović , Le-Nam Tran

We introduce a novel approach for end-to-end black-box optimization of high energy physics (HEP) detectors using local deep learning (DL) surrogates. These surrogates approximate a scalar objective function that encapsulates the complex…

Machine Learning · Computer Science 2025-03-19 Kinga Anna Wozniak , Stephen Mulligan , Jan Kieseler , Markus Klute , Francois Fleuret , Tobias Golling

Hyperparameter optimization (HPO) is important to leverage the full potential of machine learning (ML). In practice, users are often interested in multi-objective (MO) problems, i.e., optimizing potentially conflicting objectives, like…

Machine Learning · Computer Science 2024-01-12 Joseph Giovanelli , Alexander Tornede , Tanja Tornede , Marius Lindauer

Medicine is evolving beyond therapy largely predicated on anatomical information and towards incorporating patient-specific molecular biomarkers of disease for more accurate diagnosis and effective treatment. The complementary combination…

Adaptive radar waveform design grounded in information-theoretic principles is critical for advancing cognitive radar performance in complex environments. This paper investigates the optimization of phase-coded waveforms under constant…

Signal Processing · Electrical Eng. & Systems 2025-05-01 Ruofeng Yu , Caiguang Zhang , Chenyang Luo , Mengdi Bai , Shangqu Yan , Wei Yang , Yaowen Fu

Positron Emission Tomography and Magnetic Resonance Imaging (PET-MRI) systems can obtain functional and anatomical scans. PET suffers from a low signal-to-noise ratio. Meanwhile, the k-space data acquisition process in MRI is…

Image and Video Processing · Electrical Eng. & Systems 2024-07-12 Taofeng Xie , Zhuo-Xu Cui , Chen Luo , Huayu Wang , Congcong Liu , Yuanzhi Zhang , Xuemei Wang , Yanjie Zhu , Guoqing Chen , Dong Liang , Qiyu Jin , Yihang Zhou , Haifeng Wang

Mutual information (MI) is a general measure of statistical dependence with widespread application across the sciences. However, estimating MI between multi-dimensional variables is challenging because the number of samples necessary to…

Quantitative Methods · Quantitative Biology 2025-03-06 Gokul Gowri , Xiao-Kang Lun , Allon M. Klein , Peng Yin

Mutual information (MI) is a fundamental measure of statistical dependence between two variables, yet accurate estimation from finite data remains notoriously difficult. No estimator is universally reliable, and common approaches fail in…

Data Analysis, Statistics and Probability · Physics 2025-10-02 Eslam Abdelaleem , K. Michael Martini , Ilya Nemenman

The previously established LOUPE (Learning-based Optimization of the Under-sampling Pattern) framework for optimizing the k-space sampling pattern in MRI was extended in three folds: firstly, fully sampled multi-coil k-space data from the…

Image and Video Processing · Electrical Eng. & Systems 2020-07-30 Jinwei Zhang , Hang Zhang , Alan Wang , Qihao Zhang , Mert Sabuncu , Pascal Spincemaille , Thanh D. Nguyen , Yi Wang

The abundance of training data is not guaranteed in various supervised learning applications. One of these situations is the post-earthquake regional damage assessment of buildings. Querying the damage label of each building requires a…

Machine Learning · Computer Science 2021-08-17 Mohamadreza Sheibani , Ge Ou

Many applications in image-guided surgery and therapy require fast and reliable non-linear, multi-modal image registration. Recently proposed unsupervised deep learning-based registration methods have demonstrated superior performance…

Image and Video Processing · Electrical Eng. & Systems 2022-10-07 Gerard Snaauw , Michele Sasdelli , Gabriel Maicas , Stephan Lau , Johan Verjans , Mark Jenkinson , Gustavo Carneiro

Mutual Information is the metric that is used to perform link adaptation, which allows to achieve rates near capacity. The computation of adaptive transmission modes is achieved by employing the mapping between the Signal to Noise Ratio and…

Signal Processing · Electrical Eng. & Systems 2018-07-26 Pol Henarejos , Ana Pérez-Neira , Anxo Tato , Carlos Mosquera

This study demonstrates the efficacy of ML-based trend inference using data from the Large Plasma Device (LAPD). The LAPD is a flexible basic plasma science device with a high discharge repetition rate (0.25-1 Hz) and reproducible plasmas…

Plasma Physics · Physics 2025-08-07 Phil Travis , Jacob Bortnik , Troy Carter
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