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Multiple instance learning (MIL) is a powerful approach to classify whole slide images (WSIs) for diagnostic pathology. A fundamental challenge of MIL on WSI classification is to discover the \textit{critical instances} that trigger the bag…

Computer Vision and Pattern Recognition · Computer Science 2022-09-02 Zhikang Wang , Yue Bi , Tong Pan , Xiaoyu Wang , Chris Bain , Richard Bassed , Seiya Imoto , Jianhua Yao , Jiangning Song

We introduce a graphical framework for multiple instance learning (MIL) based on Markov networks. This framework can be used to model the traditional MIL definition as well as more general MIL definitions. Different levels of ambiguity --…

Machine Learning · Computer Science 2013-09-27 Hossein Hajimirsadeghi , Jinling Li , Greg Mori , Mohammad Zaki , Tarek Sayed

Weakly Supervised Object Detection (WSOD), using only image-level annotations to train object detectors, is of growing importance in object recognition. In this paper, we propose a novel deep network for WSOD. Unlike previous networks that…

Computer Vision and Pattern Recognition · Computer Science 2018-10-16 Peng Tang , Xinggang Wang , Song Bai , Wei Shen , Xiang Bai , Wenyu Liu , Alan Yuille

This paper considers a novel application of deep AUC maximization (DAM) for multi-instance learning (MIL), in which a single class label is assigned to a bag of instances (e.g., multiple 2D slices of a CT scan for a patient). We address a…

Machine Learning · Computer Science 2023-06-07 Dixian Zhu , Bokun Wang , Zhi Chen , Yaxing Wang , Milan Sonka , Xiaodong Wu , Tianbao Yang

In computational pathology, whole-slide image (WSI) classification presents a formidable challenge due to its gigapixel resolution and limited fine-grained annotations. Multiple-instance learning (MIL) offers a weakly supervised solution,…

Computer Vision and Pattern Recognition · Computer Science 2024-09-06 Renao Yan , Qiehe Sun , Cheng Jin , Yiqing Liu , Yonghong He , Tian Guan , Hao Chen

The journey of reducing noise from distant supervision (DS) generated training data has been started since the DS was first introduced into the relation extraction (RE) task. For the past decade, researchers apply the multi-instance…

Computation and Language · Computer Science 2021-06-22 Tao Chen , Haizhou Shi , Siliang Tang , Zhigang Chen , Fei Wu , Yueting Zhuang

Multiple Instance Learning (MIL) has been widely applied to medical imaging diagnosis, where bag labels are known and instance labels inside bags are unknown. Traditional MIL assumes that instances in each bag are independent samples from a…

Image and Video Processing · Electrical Eng. & Systems 2023-07-19 Yunan Wu , Francisco M. Castro-Macías , Pablo Morales-Álvarez , Rafael Molina , Aggelos K. Katsaggelos

We present a weakly supervised deep learning method to perform instance segmentation of cells present in microscopy images. Annotation of biomedical images in the lab can be scarce, incomplete, and inaccurate. This is of concern when…

Computer Vision and Pattern Recognition · Computer Science 2019-08-28 Fidel A. Guerrero-Peña , Pedro D. Marrero Fernandez , Tsang Ing Ren , Alexandre Cunha

Active Learning (AL) has emerged as a powerful approach for minimizing labeling costs by selectively sampling the most informative data for neural network model development. Effective AL for large-scale vision-language models necessitates…

Computer Vision and Pattern Recognition · Computer Science 2025-07-30 Athmanarayanan Lakshmi Narayanan , Amrutha Machireddy , Ranganath Krishnan

Multi-label Classification (MLC) assigns an instance to one or more non-exclusive classes. A challenge arises when the dataset contains a large proportion of instances with no assigned class, referred to as negative data, which can…

Machine Learning · Computer Science 2025-06-09 Dumindu Tissera , Omar Awadallah , Muhammad Umair Danish , Ayan Sadhu , Katarina Grolinger

Most of the existing learning models, particularly deep neural networks, are reliant on large datasets whose hand-labeling is expensive and time demanding. A current trend is to make the learning of these models frugal and less dependent on…

Computer Vision and Pattern Recognition · Computer Science 2022-12-12 Sebastien Deschamps , Hichem Sahbi

Positive instance detection, especially for these in positive bags (true positive instances, TPIs), plays a key role for multiple instance learning (MIL) arising from a specific classification problem only provided with bag (a set of…

Computer Vision and Pattern Recognition · Computer Science 2016-12-13 Dongkuan Xu , Jia Wu , Wei Zhang , Yingjie Tian

Both classification and regression tasks are susceptible to the biased distribution of training data. However, existing approaches are focused on the class-imbalanced learning and cannot be applied to the problems of numerical regression…

Machine Learning · Computer Science 2021-09-15 Wentai Wu , Ligang He , Weiwei Lin

We present a practical and statistically consistent scheme for actively learning binary classifiers under general loss functions. Our algorithm uses importance weighting to correct sampling bias, and by controlling the variance, we are able…

Machine Learning · Computer Science 2009-05-20 Alina Beygelzimer , Sanjoy Dasgupta , John Langford

Accurate tumor detection in digital pathology whole-slide images (WSIs) is crucial for cancer diagnosis and treatment planning. Multiple Instance Learning (MIL) has emerged as a widely used approach for weakly-supervised tumor detection…

Image and Video Processing · Electrical Eng. & Systems 2025-03-03 Marina D'Amato , Jeroen van der Laak , Francesco Ciompi

Multiple instance learning (MIL) is often used in medical imaging to classify high-resolution 2D images by processing patches or classify 3D volumes by processing slices. However, conventional MIL approaches treat instances separately,…

Machine Learning · Computer Science 2025-11-13 Ethan Harvey , Dennis Johan Loevlie , Michael C. Hughes

Imbalanced datasets are commonplace in modern machine learning problems. The presence of under-represented classes or groups with sensitive attributes results in concerns about generalization and fairness. Such concerns are further…

Machine Learning · Computer Science 2022-01-05 Mingchen Li , Xuechen Zhang , Christos Thrampoulidis , Jiasi Chen , Samet Oymak

Multiple Instance Learning (MIL) has been widely used in weakly supervised whole slide image (WSI) classification. Typical MIL methods include a feature embedding part, which embeds the instances into features via a pre-trained feature…

Computer Vision and Pattern Recognition · Computer Science 2024-08-02 Peijie Qiu , Pan Xiao , Wenhui Zhu , Yalin Wang , Aristeidis Sotiras

We present a weakly supervised instance segmentation algorithm based on deep community learning with multiple tasks. This task is formulated as a combination of weakly supervised object detection and semantic segmentation, where individual…

Computer Vision and Pattern Recognition · Computer Science 2020-11-19 Jaedong Hwang , Seohyun Kim , Jeany Son , Bohyung Han

In Multiple Instance learning (MIL), weak labels are provided at the bag level with only presence/absence information known. However, there is a considerable gap in performance in comparison to a fully supervised model, limiting the…

Machine Learning · Computer Science 2021-03-22 Anxiang Zhang , Ankit Shah , Bhiksha Raj
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