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We propose an embarrassingly simple point annotation scheme to collect weak supervision for instance segmentation. In addition to bounding boxes, we collect binary labels for a set of points uniformly sampled inside each bounding box. We…

Computer Vision and Pattern Recognition · Computer Science 2022-06-17 Bowen Cheng , Omkar Parkhi , Alexander Kirillov

Cell classification and counting in immunohistochemical cytoplasm staining images play a pivotal role in cancer diagnosis. Weakly supervised learning is a potential method to deal with labor-intensive labeling. However, the inconstant cell…

Image and Video Processing · Electrical Eng. & Systems 2022-03-01 Shichuan Zhang , Chenglu Zhu , Honglin Li , Jiatong Cai , Lin Yang

Investigation of cell structure is hardly imaginable without bright-field microscopy. Numerous modifications such as depth-wise scanning or videoenhancement make this method being state-of-the-art. This raises a question what maximal…

Image and Video Processing · Electrical Eng. & Systems 2020-10-29 Kirill Lonhus , Renata Rychtarikova , Ganna Platonova , Dalibor Stys

Current biological and medical research is aimed at obtaining a detailed spatiotemporal map of a live cell's interior to describe and predict cell's physiological state. We present here an algorithm for complete 3-D modelling of cellular…

Quantitative Methods · Quantitative Biology 2017-04-03 Renata Rychtarikova , Tomas Nahlik , Kevin Shi , Daria Malakhova , Petr Machacek , Rebecca Smaha , Jan Urban , Dalibor Stys

Medical vision foundation models remain limited in downstream tasks, particularly volumetric medical image segmentation. While fine-tuning on labeled target-domain data improves performance, existing approaches typically rely on randomly…

Image and Video Processing · Electrical Eng. & Systems 2026-05-07 Jin Yang , Daniel S. Marcus , Aristeidis Sotiras

The most realistic information about the transparent sample such as a live cell can be obtained only using bright-field light microscopy. At high-intensity pulsing LED illumination, we captured a primary 12-bit-per-channel (bpc) response…

Image and Video Processing · Electrical Eng. & Systems 2021-08-18 Ganna Platonova , Dalibor Stys , Pavel Soucek , Kirill Lonhus , Jan Valenta , Renata Rychtarikova

Semantic segmentation is a core computer vision problem, but the high costs of data annotation have hindered its wide application. Weakly-Supervised Semantic Segmentation (WSSS) offers a cost-efficient workaround to extensive labeling in…

Computer Vision and Pattern Recognition · Computer Science 2024-05-13 Elham Ravanbakhsh , Cheng Niu , Yongqing Liang , J. Ramanujam , Xin Li

Text segmentation is a challenging vision task with many downstream applications. Current text segmentation methods require pixel-level annotations, which are expensive in the cost of human labor and limited in application scenarios. In…

Computer Vision and Pattern Recognition · Computer Science 2023-03-24 Xinyan Zu , Haiyang Yu , Bin Li , Xiangyang Xue

Fluorescence microscopy is an essential tool for the analysis of 3D subcellular structures in tissue. An important step in the characterization of tissue involves nuclei segmentation. In this paper, a two-stage method for segmentation of…

Image and Video Processing · Electrical Eng. & Systems 2020-01-10 David Joon Ho , Shuo Han , Chichen Fu , Paul Salama , Kenneth W. Dunn , Edward J. Delp

A major obstacle in instance segmentation is that existing methods often need many per-pixel labels in order to be effective. These labels require large human effort and for certain applications, such labels are not readily available. To…

Computer Vision and Pattern Recognition · Computer Science 2019-07-03 Issam H. Laradji , David Vazquez , Mark Schmidt

Generally, microscopy image analysis in biology relies on the segmentation of individual nuclei, using a dedicated stained image, to identify individual cells. However stained nuclei have drawbacks like the need for sample preparation, and…

Image and Video Processing · Electrical Eng. & Systems 2022-11-08 Gendarme Mathieu , Lambert Annika M. , El Debs Bachir

Weakly supervised instance segmentation (WSIS) using only image-level labels is a challenging task due to the difficulty of aligning coarse annotations with the finer task. However, with the advancement of deep neural networks (DNNs), WSIS…

Computer Vision and Pattern Recognition · Computer Science 2024-02-13 Zecheng Li , Zening Zeng , Yuqi Liang , Jin-Gang Yu

Advancements in digital imaging technologies have sparked increased interest in using multiplexed immunofluorescence (mIF) images to visualise and identify the interactions between specific immunophenotypes with the tumour microenvironment…

Image and Video Processing · Electrical Eng. & Systems 2024-07-01 Piumi Sandarenu , Julia Chen , Iveta Slapetova , Lois Browne , Peter H. Graham , Alexander Swarbrick , Ewan K. A. Millar , Yang Song , Erik Meijering

Two major causes of death in the United States and worldwide are stroke and myocardial infarction. The underlying cause of both is thrombi released from ruptured or eroded unstable atherosclerotic plaques that occlude vessels in the heart…

Computer Vision and Pattern Recognition · Computer Science 2022-08-02 Nazanin Moradinasab , Yash Sharma , Laura S. Shankman , Gary K. Owens , Donald E. Brown

This work addresses the task of completely weakly supervised class-incremental learning for semantic segmentation to learn segmentation for both base and additional novel classes using only image-level labels. While class-incremental…

Computer Vision and Pattern Recognition · Computer Science 2025-05-19 David Minkwan Kim , Soeun Lee , Byeongkeun Kang

Brightfield microscopy of unstained live cells is challenging due to low contrast, dynamic morphology, uneven illumination, and lack of labels. Deep learning achieved SOTA performance on stained, high-contrast images but needs large labeled…

Image and Video Processing · Electrical Eng. & Systems 2025-10-15 Surajit Das , Pavel Zun

In microscopy image cell segmentation, it is common to train a deep neural network on source data, containing different types of microscopy images, and then fine-tune it using a support set comprising a few randomly selected and annotated…

Computer Vision and Pattern Recognition · Computer Science 2022-11-21 Youssef Dawoud , Arij Bouazizi , Katharina Ernst , Gustavo Carneiro , Vasileios Belagiannis

Existing salient instance detection (SID) methods typically learn from pixel-level annotated datasets. In this paper, we present the first weakly-supervised approach to the SID problem. Although weak supervision has been considered in…

Computer Vision and Pattern Recognition · Computer Science 2021-11-22 Xin Tian , Ke Xu , Xin Yang , Baocai Yin , Rynson W. H. Lau

Nodule segmentation from breast ultrasound images is challenging yet essential for the diagnosis. Weakly-supervised segmentation (WSS) can help reduce time-consuming and cumbersome manual annotation. Unlike existing weakly-supervised…

Computer Vision and Pattern Recognition · Computer Science 2021-08-03 Yuhao Huang , Xin Yang , Yuxin Zou , Chaoyu Chen , Jian Wang , Haoran Dou , Nishant Ravikumar , Alejandro F Frangi , Jianqiao Zhou , Dong Ni

Accurate delineation of individual cells in microscopy videos is essential for studying cellular dynamics, yet separating touching or overlapping instances remains a persistent challenge. Although foundation-model for segmentation such as…

Computer Vision and Pattern Recognition · Computer Science 2026-03-24 Thomas Mendelson , Joshua Francois , Galit Lahav , Tammy Riklin-Raviv