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Collective behaviors in cellular systems are regulated not only by biochemical signalling pathways but also by intercellular mechanical forces, whose quantification in contractile monolayers remains poorly understood. Here, by integrating…

Quantitative Methods · Quantitative Biology 2025-10-30 Yucheng Huo , Kexin Guo , Massimo Paradiso , K. Jimmy Hsia

The paper addresses the underlying source of two forms of induced anisotropy in granular materials: contact orientation anisotropy and contact force anisotropy. A rational, mathematical structure is reviewed for the manner in which fabric…

Soft Condensed Matter · Physics 2019-01-23 Matthew R. Kuhn

We have recently developed some simple continuum models of static granular media which display "fragile" behaviour: they predict that the medium is unable to support certain types of infinitesimal load (which we call "incompatible" loads)…

Materials Science · Physics 2009-10-31 M. E. Cates , J. P. Wittmer , J. -P. Bouchaud , P. Claudin

We investigate theoretically how the stress propagation characteristics of granular materials evolve as they are subjected to increasing pressures, comparing the results of a two-dimensional scalar lattice model to those of a molecular…

Statistical Mechanics · Physics 2009-10-31 M. L. Nguyen , S. N. Coppersmith

We show how strain stiffening affects the elastic response to internal forces, caused either by material defects and inhomogeneities or by active forces that molecular motors generate in living cells. For a spherical force dipole in a…

Soft Condensed Matter · Physics 2012-05-04 Yair Shokef , Samuel A. Safran

Light forces induced by scattering and absorption in elastic dielectrics lead to local density modulations and deformations. These perturbations in turn modify light propagation in the medium and generate an intricate nonlinear response. We…

Optics · Physics 2012-11-01 Matthias Sonnleitner , Monika Ritsch-Marte , Helmut Ritsch

In comparative and developmental neuroanatomy one encounters questions regarding the deformation of neural tissue under stress. The motivation of this note is an observation (Barbas {\it et al}) that at cortical folds or gyri, the layers of…

Tissues and Organs · Quantitative Biology 2007-05-23 Partha P. Mitra

The stress response of a granular assembly subject to different changes of boundary conditions is studied experimentally in order to define the stress propagation characteristics. These results demonstrate that no simple and single…

Soft Condensed Matter · Physics 2007-05-23 P. Evesque

Spatially confined rigid membranes reorganize their morphology in response to the imposed constraints. A crumpled elastic sheet presents a complex pattern of random folds focusing the deformation energy while compressing a membrane resting…

Tuning of active prestress e.g. through activity of molecular motors constitutes a powerful cellular tool to adjust cellular stiffness through nonlinear material properties. Understanding this tool is an important prerequisite for our…

Soft Condensed Matter · Physics 2018-08-24 Elisabeth Fischer-Friedrich

The unique nonlinear mechanics of the fibrous extracellular matrix (ECM) facilitates long-range cell-cell mechanical communications that would be impossible on linear elastic substrates. Past research has described the contribution of two…

Biological Physics · Physics 2019-05-14 Shahar Goren , Yoni Koren , Xinpeng Xu , Ayelet Lesman

Connecting cell behavior to tissue shape and mechanics is a key challenge in the physics of morphogenesis. Cytoskeletal turnover precludes a fixed reference state, and tensions are actively generated independently of strain; so conventional…

Soft Condensed Matter · Physics 2026-05-28 Nikolas H. Claussen , Fridtjof Brauns , Boris I. Shraiman

Mechanical signaling plays a key role in biological processes like embryo development and cancer growth. One prominent way to probe mechanical properties of tissues is to study their response to externally applied forces. Using a…

Soft Condensed Matter · Physics 2017-04-18 D. A. Matoz-Fernandez , Elisabeth Agoritsas , Jean-Louis Barrat , Eric Bertin , Kirsten Martens

Shear cracks propagation is a basic dynamical process that mediates interfacial failure. We develop a general weakly nonlinear elastic theory of shear cracks and show that these experience tensile-mode crack tip deformation, including…

Materials Science · Physics 2015-06-03 Roi Harpaz , Eran Bouchbinder

Materials with negative Poisson ratio have the counter-intuitive property of expanding laterally when they are stretched longitudinally. They are accordingly termed auxetic, from the Greek auxesis meaning to increase. Experimental studies…

Statistical Mechanics · Physics 2024-05-02 Suzanne M. Fielding

Using confocal microscopy, we measure the packing geometry and interdroplet forces as a function of the osmotic pressure in a 3D emulsion system. We find that the nonlinear elastic response of the pressure with density is not a result of…

Soft Condensed Matter · Physics 2015-06-11 Ivane Jorjadze , Lea-Laetitia Pontani , Jasna Brujic

Coordinated motion of cell monolayers during epithelial wound healing and tissue morphogenesis involves mechanical stress generation. Here we propose a model for the dynamics of epithelial expansion that couples mechanical deformations in…

Soft Condensed Matter · Physics 2015-06-09 Shiladitya Banerjee , Kazage J. C. Utuje , M. Cristina Marchetti

Stress-strain measurements and ultrasound propagation experiments in glass bead packs have been simultaneously conducted to characterize the stress-induced anisotropy under uniaxial loading. These measurements, realized respectively with…

Soft Condensed Matter · Physics 2015-05-14 Yacine Khidas , Xiaoping Jia

We experimentally probe the anisotropy of the fabric of weakly vibrated, flowing granular media. Depending on the driving parameters --- flow rate and vibration strength --- this anisotropy varies significantly. We show how the anisotropy…

Soft Condensed Matter · Physics 2015-11-04 Geert Wortel , Martin van Hecke

Within developing embryos, tissues flow and reorganize dramatically on timescales as short as minutes. This includes epithelial tissues, which often narrow and elongate in convergent extension movements due to anisotropies in external…

Tissues and Organs · Quantitative Biology 2020-06-24 Xun Wang , Matthias Merkel , Leo B. Sutter , Gonca Erdemci-Tandogan , M. Lisa Manning , Karen E. Kasza