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While modern biotechnologies allow synthesizing new proteins and function measurements at scale, efficiently exploring a protein sequence space and engineering it remains a daunting task due to the vast sequence space of any given protein.…

Biomolecules · Quantitative Biology 2024-01-15 Jiahao Qiu , Hui Yuan , Jinghong Zhang , Wentao Chen , Huazheng Wang , Mengdi Wang

Neural prediction offers a promising approach to forecasting the individual variability of neurocognitive functions and disorders and providing prognostic indicators for personalized invention. However, it is challenging to translate neural…

Machine Learning · Computer Science 2025-12-02 Yanlin Wang , Nancy M Young , Patrick C M Wong

The literature on bandit learning and regret analysis has focused on contexts where the goal is to converge on an optimal action in a manner that limits exploration costs. One shortcoming imposed by this orientation is that it does not…

Machine Learning · Computer Science 2017-05-01 Daniel Russo , David Tse , Benjamin Van Roy

Thompson Sampling (TS) is one of the most effective algorithms for solving contextual multi-armed bandit problems. In this paper, we propose a new algorithm, called Neural Thompson Sampling, which adapts deep neural networks for both…

Machine Learning · Computer Science 2022-01-03 Weitong Zhang , Dongruo Zhou , Lihong Li , Quanquan Gu

Directed evolution is an iterative laboratory process of designing proteins with improved function by iteratively synthesizing new protein variants and evaluating their desired property with expensive and time-consuming biochemical…

Machine Learning · Computer Science 2025-09-08 Matouš Soldát , Jiří Kléma

The multi-armed bandit problem is a popular model for studying exploration/exploitation trade-off in sequential decision problems. Many algorithms are now available for this well-studied problem. One of the earliest algorithms, given by W.…

Machine Learning · Computer Science 2012-04-10 Shipra Agrawal , Navin Goyal

Motivated by the pressing need for efficient optimization in online recommender systems, we revisit the cascading bandit model proposed by Kveton et al. (2015). While Thompson sampling (TS) algorithms have been shown to be empirically…

Machine Learning · Computer Science 2021-05-18 Zixin Zhong , Wang Chi Cheung , Vincent Y. F. Tan

We derive an alternative proof for the regret of Thompson sampling (\ts) in the stochastic linear bandit setting. While we obtain a regret bound of order $\widetilde{O}(d^{3/2}\sqrt{T})$ as in previous results, the proof sheds new light on…

Machine Learning · Statistics 2019-11-06 Marc Abeille , Alessandro Lazaric

Differential Evolution (DE) is a renowned optimization stratagem that can easily solve nonlinear and comprehensive problems. DE is a well known and uncomplicated population based probabilistic approach for comprehensive optimization. It has…

Neural and Evolutionary Computing · Computer Science 2015-06-22 Sandeep Kumar , Vivek Kumar Sharma , Rajani Kumari

We study Thompson Sampling-based algorithms for stochastic bandits with bounded rewards. As the existing problem-dependent regret bound for Thompson Sampling with Gaussian priors [Agrawal and Goyal, 2017] is vacuous when $T \le 288 e^{64}$,…

Machine Learning · Computer Science 2024-05-03 Bingshan Hu , Zhiming Huang , Tianyue H. Zhang , Mathias Lécuyer , Nidhi Hegde

Differential evolution (DE) is a simple but powerful evolutionary algorithm, which has been widely and successfully used in various areas. In this paper, an event-triggered impulsive control scheme (ETI) is introduced to improve the…

Neural and Evolutionary Computing · Computer Science 2015-12-25 Wei Du , Sunney Yung Sun Leung , Yang Tang , Athanasios V. Vasilakos

As two popular schools of machine learning, online learning and evolutionary computations have become two important driving forces behind real-world decision making engines for applications in biomedicine, economics, and engineering fields.…

Neural and Evolutionary Computing · Computer Science 2022-05-24 Baihan Lin

Much of the recent literature on bandit learning focuses on algorithms that aim to converge on an optimal action. One shortcoming is that this orientation does not account for time sensitivity, which can play a crucial role when learning an…

Machine Learning · Computer Science 2020-01-09 Daniel Russo , Benjamin Van Roy

In the Multi-Armed Bandit (MAB) problem, there is a given set of arms with unknown reward models. At each time, a player selects one arm to play, aiming to maximize the total expected reward over a horizon of length T. An approach based on…

Optimization and Control · Mathematics 2013-03-12 Sattar Vakili , Keqin Liu , Qing Zhao

This paper considers the use of a simple posterior sampling algorithm to balance between exploration and exploitation when learning to optimize actions such as in multi-armed bandit problems. The algorithm, also known as Thompson Sampling,…

Machine Learning · Computer Science 2014-02-04 Daniel Russo , Benjamin Van Roy

This work introduces Directed-Evolution (DE) method for sparsification of neural networks, where the relevance of parameters to the network accuracy is directly assessed and the parameters that produce the least effect on accuracy when…

Machine Learning · Computer Science 2022-06-14 Luiz M Franca-Neto

We investigate the extent to which offline demonstration data can improve online learning. It is natural to expect some improvement, but the question is how, and by how much? We show that the degree of improvement must depend on the quality…

Machine Learning · Computer Science 2023-05-18 Botao Hao , Rahul Jain , Tor Lattimore , Benjamin Van Roy , Zheng Wen

Restless bandit problems assume time-varying reward distributions of the arms, which adds flexibility to the model but makes the analysis more challenging. We study learning algorithms over the unknown reward distributions and prove a…

Machine Learning · Computer Science 2019-10-15 Young Hun Jung , Marc Abeille , Ambuj Tewari

Thompson Sampling is one of the most widely used and studied bandit algorithms, known for its simple structure, low regret performance, and solid theoretical guarantees. Yet, in stark contrast to most other families of bandit algorithms,…

Machine Learning · Computer Science 2026-05-28 Yanlin Qu , Hongseok Namkoong , Assaf Zeevi

A long line of works characterizes the sample complexity of regret minimization in sequential decision-making by min-max programs. In the corresponding saddle-point game, the min-player optimizes the sampling distribution against an…

Machine Learning · Computer Science 2024-03-18 Johannes Kirschner , Seyed Alireza Bakhtiari , Kushagra Chandak , Volodymyr Tkachuk , Csaba Szepesvári
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