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Backpropagation, a foundational algorithm for training artificial neural networks, predominates in contemporary deep learning. Although highly successful, it is widely considered biologically implausible, because it relies on precise…

Machine Learning · Computer Science 2025-10-07 Li Ji-An , Marcus K. Benna

Stochastic gradient descent with backpropagation is the workhorse of artificial neural networks. It has long been recognized that backpropagation fails to be a biologically plausible algorithm. Fundamentally, it is a non-local procedure --…

Machine Learning · Statistics 2021-12-24 Ganlin Song , Ruitu Xu , John Lafferty

The brain processes information through many layers of neurons. This deep architecture is representationally powerful, but it complicates learning by making it hard to identify the responsible neurons when a mistake is made. In machine…

Neurons and Cognition · Quantitative Biology 2014-11-04 Timothy P. Lillicrap , Daniel Cownden , Douglas B. Tweed , Colin J. Akerman

In artificial neural networks trained with gradient descent, the weights used for processing stimuli are also used during backward passes to calculate gradients. For the real brain to approximate gradients, gradient information would have…

Neurons and Cognition · Quantitative Biology 2020-02-04 Jordan Guerguiev , Konrad P. Kording , Blake A. Richards

Backpropagation is the cornerstone of deep learning, but its reliance on symmetric weight transport and global synchronization makes it computationally expensive and biologically implausible. Feedback alignment offers a promising…

Machine Learning · Computer Science 2025-05-28 Jeonghwan Cheon , Jaehyuk Bae , Se-Bum Paik

Artificial neural networks are most commonly trained with the back-propagation algorithm, where the gradient for learning is provided by back-propagating the error, layer by layer, from the output layer to the hidden layers. A recently…

Machine Learning · Statistics 2016-12-22 Arild Nøkland

The Error Diffusion Learning Algorithm (EDLA) is a learning scheme that performs synaptically local weight updates driven by a single, globally defined error signal. Although originally proposed as an alternative to backpropagation, its…

Machine Learning · Computer Science 2026-03-31 Kazuhisa Fujita

Current algorithms for deep learning probably cannot run in the brain because they rely on weight transport, where forward-path neurons transmit their synaptic weights to a feedback path, in a way that is likely impossible biologically. An…

Machine Learning · Computer Science 2020-01-13 Mohamed Akrout , Collin Wilson , Peter C. Humphreys , Timothy Lillicrap , Douglas Tweed

Recent advances in deep neural networks (DNNs) owe their success to training algorithms that use backpropagation and gradient-descent. Backpropagation, while highly effective on von Neumann architectures, becomes inefficient when scaling to…

Neural and Evolutionary Computing · Computer Science 2019-05-10 Brian Crafton , Abhinav Parihar , Evan Gebhardt , Arijit Raychowdhury

Ongoing studies have identified similarities between neural representations in biological networks and in deep artificial neural networks. This has led to renewed interest in developing analogies between the backpropagation learning…

Neural and Evolutionary Computing · Computer Science 2019-06-11 Theodore H. Moskovitz , Ashok Litwin-Kumar , L. F. Abbott

Training deep neural networks on large-scale datasets requires significant hardware resources whose costs (even on cloud platforms) put them out of reach of smaller organizations, groups, and individuals. Backpropagation, the workhorse for…

Machine Learning · Computer Science 2020-09-22 Alexander Ororbia , Ankur Mali , Daniel Kifer , C. Lee Giles

Error backpropagation is a highly effective mechanism for learning high-quality hierarchical features in deep networks. Updating the features or weights in one layer, however, requires waiting for the propagation of error signals from…

Neural and Evolutionary Computing · Computer Science 2017-11-21 Hesham Mostafa , Vishwajith Ramesh , Gert Cauwenberghs

The backpropagation of error algorithm (backprop) has been instrumental in the recent success of deep learning. However, a key question remains as to whether backprop can be formulated in a manner suitable for implementation in neural…

Neural and Evolutionary Computing · Computer Science 2020-10-13 Beren Millidge , Alexander Tschantz , Anil K Seth , Christopher L Buckley

Backpropagation is the core learning mechanism underlying deep learning. However, whether and how this algorithm is implemented in the brain remains highly debated. In particular, while forward activations of pretrained models reliably map…

The backpropagation algorithm has experienced remarkable success in training large-scale artificial neural networks; however, its biological plausibility has been strongly criticized, and it remains an open question whether the brain…

Neural and Evolutionary Computing · Computer Science 2026-03-27 Bariscan Bozkurt , Cengiz Pehlevan , Alper T Erdogan

Deep artificial neural networks (DNNs) are typically trained via gradient-based learning algorithms, namely backpropagation. Evolution strategies (ES) can rival backprop-based algorithms such as Q-learning and policy gradients on…

Neural and Evolutionary Computing · Computer Science 2018-04-24 Felipe Petroski Such , Vashisht Madhavan , Edoardo Conti , Joel Lehman , Kenneth O. Stanley , Jeff Clune

Recurrent neural networks are a successful neural architecture for many time-dependent problems, including time series analysis, forecasting, and modeling of dynamical systems. Training such networks with backpropagation through time is a…

Machine Learning · Computer Science 2025-01-30 Erik Lien Bolager , Ana Cukarska , Iryna Burak , Zahra Monfared , Felix Dietrich

Backpropagation is driving today's artificial neural networks (ANNs). However, despite extensive research, it remains unclear if the brain implements this algorithm. Among neuroscientists, reinforcement learning (RL) algorithms are often…

Neurons and Cognition · Quantitative Biology 2020-04-24 Benjamin James Lansdell , Prashanth Ravi Prakash , Konrad Paul Kording

Developing strong AI signifies the arrival of technological singularity, contributing greatly to advancing human civilization and resolving social issues. Neural networks (NNs) and deep learning, which utilize NNs, are expected to lead to…

Machine Learning · Computer Science 2024-09-09 Kei Itoh

The back-propagation (BP) algorithm has been considered the de-facto method for training deep neural networks. It back-propagates errors from the output layer to the hidden layers in an exact manner using the transpose of the feedforward…

Neural and Evolutionary Computing · Computer Science 2018-05-01 Hongyin Luo , Jie Fu , James Glass
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