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A core challenge in structural biophysics is generating biomolecular conformations that are both physically plausible and consistent with experimental measurements. While sequence-to-structure diffusion models provide powerful priors,…

Machine Learning · Computer Science 2026-05-15 Minhuan Li , Jiequn Han , Pilar Cossio , Luhuan Wu

A growing body of work underlines striking similarities between biological neural networks and recurrent, binary neural networks. A relatively smaller body of work, however, discusses similarities between learning dynamics employed in deep…

Neural and Evolutionary Computing · Computer Science 2020-05-22 Jacques Kaiser , Hesham Mostafa , Emre Neftci

After a more than decade-long period of relatively little research activity in the area of recurrent neural networks, several new developments will be reviewed here that have allowed substantial progress both in understanding and in…

Machine Learning · Computer Science 2012-12-17 Yoshua Bengio , Nicolas Boulanger-Lewandowski , Razvan Pascanu

To unveil how the brain learns, ongoing work seeks biologically-plausible approximations of gradient descent algorithms for training recurrent neural networks (RNNs). Yet, beyond task accuracy, it is unclear if such learning rules converge…

Neural and Evolutionary Computing · Computer Science 2023-01-18 Yuhan Helena Liu , Arna Ghosh , Blake A. Richards , Eric Shea-Brown , Guillaume Lajoie

Despite the striking successes of deep neural networks trained with gradient-based optimization, these methods differ fundamentally from their biological counterparts. This gap raises key questions about how nature achieves robust,…

Machine Learning · Computer Science 2025-10-15 Mattia Scardecchia

The backpropagation of error algorithm used to train deep neural networks has been fundamental to the successes of deep learning. However, it requires sequential backward updates and non-local computations, which make it challenging to…

Neural and Evolutionary Computing · Computer Science 2022-02-22 Beren Millidge , Tommaso Salvatori , Yuhang Song , Rafal Bogacz , Thomas Lukasiewicz

If edge devices are to be deployed to critical applications where their decisions could have serious financial, political, or public-health consequences, they will need a way to signal when they are not sure how to react to their…

Neural and Evolutionary Computing · Computer Science 2020-05-11 Nathan Wycoff , Prasanna Balaprakash , Fangfang Xia

Despite extensive theoretical work on biologically plausible learning rules, clear evidence about whether and how such rules are implemented in the brain has been difficult to obtain. We consider biologically plausible supervised- and…

Neural and Evolutionary Computing · Computer Science 2022-10-18 Jacob P. Portes , Christian Schmid , James M. Murray

Prompt learning has emerged as an effective technique for fine-tuning large-scale foundation models for downstream tasks. However, conventional prompt learning methods are prone to overfitting and can struggle with out-of-distribution…

Synaptic plasticity is widely accepted to be the mechanism behind learning in the brain's neural networks. A central question is how synapses, with access to only local information about the network, can still organize collectively and…

Neural and Evolutionary Computing · Computer Science 2019-12-06 Dina Obeid , Hugo Ramambason , Cengiz Pehlevan

In a physical neural system, where storage and processing are intimately intertwined, the rules for adjusting the synaptic weights can only depend on variables that are available locally, such as the activity of the pre- and post-synaptic…

Machine Learning · Computer Science 2016-10-25 Pierre Baldi , Peter Sadowski

By and large, Backpropagation (BP) is regarded as one of the most important neural computation algorithms at the basis of the progress in machine learning, including the recent advances in deep learning. However, its computational structure…

Artificial Intelligence · Computer Science 2018-08-22 Alessandro Betti , Marco Gori , Giuseppe Marra

Animals excel at adapting their intentions, attention, and actions to the environment, making them remarkably efficient at interacting with a rich, unpredictable and ever-changing external world, a property that intelligent machines…

Machine Learning · Computer Science 2019-12-09 Nicolas Vecoven , Damien Ernst , Antoine Wehenkel , Guillaume Drion

Large multilayer neural networks trained with backpropagation have recently achieved state-of-the-art results in a wide range of problems. However, using backprop for neural net learning still has some disadvantages, e.g., having to tune a…

Machine Learning · Statistics 2015-07-16 José Miguel Hernández-Lobato , Ryan P. Adams

While surrogate backpropagation proves useful for training deep spiking neural networks (SNNs), incorporating biologically inspired local signals on a large scale remains challenging. This difficulty stems primarily from the high memory…

Neural and Evolutionary Computing · Computer Science 2025-12-09 Yuchen Tian , Samuel Tensingh , Jason Eshraghian , Nhan Duy Truong , Omid Kavehei

Spiking neural networks (SNNs) offer a biologically grounded and energy-efficient alternative to conventional neural architectures; however, they struggle with long-range temporal dependencies due to fixed synaptic and membrane time…

Neural and Evolutionary Computing · Computer Science 2026-01-06 Sarim Chaudhry

Biological neural networks are characterized by their high degree of plasticity, a core property that enables the remarkable adaptability of natural organisms. Importantly, this ability affects both the synaptic strength and the topology of…

Neural and Evolutionary Computing · Computer Science 2024-06-17 Erwan Plantec , Joachin W. Pedersen , Milton L. Montero , Eleni Nisioti , Sebastian Risi

A major drawback of backpropagation through time (BPTT) is the difficulty of learning long-term dependencies, coming from having to propagate credit information backwards through every single step of the forward computation. This makes BPTT…

Artificial Intelligence · Computer Science 2017-11-08 Nan Rosemary Ke , Anirudh Goyal , Olexa Bilaniuk , Jonathan Binas , Laurent Charlin , Chris Pal , Yoshua Bengio

Large language models display in-context learning as an emergent effect of scale, but they rely on static weights during inference. In contrast, biological systems continually adapt via synaptic plasticity. We investigate whether explicit,…

Neural and Evolutionary Computing · Computer Science 2025-11-06 Siddharth Chaudhary

Recurrent neural networks in the chaotic regime exhibit complex dynamics reminiscent of high-level cortical activity during behavioral tasks. However, existing training methods for such networks are either biologically implausible, or…

Neurons and Cognition · Quantitative Biology 2015-12-09 Thomas Miconi