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Aging is a fundamental aspect of living systems that undergo a progressive deterioration of physiological function with age and an increase of vulnerability to disease and death. Living systems, known as complex systems, require complexity…

Populations and Evolution · Quantitative Biology 2010-11-15 Byung Mook Weon , Jung Ho Je

We introduce a model for describing the dynamics of large numbers of interacting cells. The fundamental dynamical variables in the model are sub-cellular elements, which interact with each other through phenomenological intra- and…

Quantitative Methods · Quantitative Biology 2007-05-23 T. J. Newman

This new long version of my 1983 paper suggests the goals you might have for your system -- Simple, Timely, Efficient, Adaptable, Dependable, Yummy (STEADY) -- and techniques for achieving them -- Approximate, Incremental, Divide & Conquer…

Distributed, Parallel, and Cluster Computing · Computer Science 2021-08-23 Butler Lampson

Biological systems are generally complicated and/or complex. In the former approach, one sets up a model with a large number of parameters to describe the system in detail. The latter approach focuses on understanding the universal aspects…

Biological Physics · Physics 2026-03-19 Kunihiko Kaneko

Biological organisms are adaptive, able to function in unpredictably changing environments. Drawing on recent nonequilibrium physics, we show that in adaptation, fitness has two components parameterized by observable coordinates: a static…

Statistical Mechanics · Physics 2026-02-19 Ying-Jen Yang , Charles D. Kocher , Ken A. Dill

Biomaterial systems have allowed for the in vitro production of complex, emergent tissue behaviors that were not possible with conventional 2D culture systems allowing for analysis of the normal development as well as disease processes. We…

Tissues and Organs · Quantitative Biology 2019-10-16 Matthew S Hall , Joseph T Decker , Lonnie D Shea

Energy and pollution are urging problems of the 21th century. By gradually changing the actual power grid system, smart grid may evolve into different systems by means of size, elements and strategies, but its fundamental requirements and…

Optimization and Control · Mathematics 2025-12-19 Soufian Ben Amor , Alain Bui , Guillaume Guerard

Information theory and the framework of information dynamics have been used to provide tools to characterise complex systems. In particular, we are interested in quantifying information storage, information modification and information…

Information Theory · Computer Science 2013-03-25 Oliver Obst , Joschka Boedecker , Benedikt Schmidt , Minoru Asada

Modularity is a general principle present in many fields. It offers attractive advantages, including, among others, ease of conceptualization, interpretability, scalability, module combinability, and module reusability. The deep learning…

Machine Learning · Computer Science 2023-10-03 Haozhe Sun , Isabelle Guyon

Living systems, from single cells to higher vertebrates, receive a continuous stream of non-stationary inputs that they sense, e.g., via cell surface receptors or sensory organs. Integrating these time-varying, multi-sensory, and often…

Other Quantitative Biology · Quantitative Biology 2024-04-17 Daniel Koch , Akhilesh Nandan , Gayathri Ramesan , Aneta Koseska

Typically, AI researchers and roboticists try to realize intelligent behavior in machines by tuning parameters of a predefined structure (body plan and/or neural network architecture) using evolutionary or learning algorithms. Another but…

Artificial Intelligence · Computer Science 2018-06-21 Sam Kriegman , Nick Cheney , Francesco Corucci , Josh C. Bongard

Motility is an essential factor for an organism's survival and diversification. With the advent of novel single-cell technologies, analytical frameworks and theoretical methods, we can begin to probe the complex lives of microscopic motile…

Manufacturing companies face challenges when it comes to quickly adapting their production control to fluctuating demands or changing requirements. Control approaches that encapsulate production functions as services have shown to be…

Artificial Intelligence · Computer Science 2022-07-26 Aljosha Köcher , Rene Heesch , Niklas Widulle , Anna Nordhausen , Julian Putzke , Alexander Windmann , Oliver Niggemann

Robustness, the insensitivity of some of a biological system's functionalities to a set of distinct conditions, is intimately linked to fitness. Recent studies suggest that it may also play a vital role in enabling the evolution of species.…

Adaptation and Self-Organizing Systems · Physics 2011-12-15 James M Whitacre , Axel Bender

Redundancy is a fundamental characteristic of many biological processes such as those in the genetic, visual, muscular and nervous system; yet its function has not been fully understood. The conventional interpretation of redundancy is that…

Information Theory · Computer Science 2019-02-04 Anh Tuan Nguyen , Jian Xu , Diu Khue Luu , Qi Zhao , Zhi Yang

The fast changing reality in technical and natural domains perceived by always more accurate observations has drawn attention on new and very broad class of systems with specific behaviour represented under the common wording complexity.…

Adaptation and Self-Organizing Systems · Physics 2007-06-06 Michel Cotsaftis

Animals (especially humans) have an amazing ability to learn new tasks quickly, and switch between them flexibly. How brains support this ability is largely unknown, both neuroscientifically and algorithmically. One reasonable supposition…

Machine Learning · Computer Science 2017-06-23 Kevin T. Feigelis , Daniel L. K. Yamins

Multitask learning algorithms are typically designed assuming some fixed, a priori known latent structure shared by all the tasks. However, it is usually unclear what type of latent task structure is the most appropriate for a given…

Machine Learning · Computer Science 2012-07-03 Alexandre Passos , Piyush Rai , Jacques Wainer , Hal Daume

Collective systems that self-organise to maximise the group's ability to collect and distribute information can be successful in environments with high spatial and temporal variation. Such organisations are abundant in nature, as sharing…

Populations and Evolution · Quantitative Biology 2025-10-28 R. S. Walker , G. Ramos-Fernandez , D. Boyer , S. E. Smith-Aguilar , X. O'Neill , M. J. Silk

The aim of this paper is to propose an alternative behavioural definition of computation (and of a computer) based simply on whether a system is capable of reacting to the environment-the input-as reflected in a measure of programmability.…

Logic in Computer Science · Computer Science 2012-11-26 Hector Zenil