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Increased availability of data and accessibility of computational tools in recent years have created unprecedented opportunities for scientific research driven by statistical analysis. Inherent limitations of statistics impose constrains on…

Genomics · Quantitative Biology 2016-09-13 Olga A. Vsevolozhskaya , Gabriel Ruiz , Dmitri V. Zaykin

After some general remarks about the interrelation between philosophical and statistical thinking, the discussion centres largely on significance tests. These are defined as the calculation of $p$-values rather than as formal procedures for…

Statistics Theory · Mathematics 2007-06-13 Deborah G. Mayo , D. R. Cox

Attacks on the P-value are nothing new, but the recent attacks are increasingly more serious. They come from more mainstream sources, with widening targets such as a call to retire the significance testing altogether. While well meaning, I…

Other Statistics · Statistics 2022-01-11 Yudi Pawitan

Verifying that a statistically significant result is scientifically meaningful is not only good scientific practice, it is a natural way to control the Type I error rate. Here we introduce a novel extension of the p-value - a…

Methodology · Statistics 2018-07-04 Jeffrey D. Blume , Lucy DAgostino McGowan , William D. Dupont , Robert A. Greevy

The Full Bayesian Significance Test (FBST) for precise hypotheses was presented by Pereira and Stern (1999) as a Bayesian alternative instead of the traditional significance test based on p-value. The FBST uses the evidence in favor of the…

Methodology · Statistics 2018-08-31 Alejandra Estefanía Patiño Hoyos , Victor Fossaluza

What are the criteria that a measure of statistical evidence should satisfy? It is argued that a measure of evidence should be consistent. Consistency is an asymptotic criterion: the probability that if a measure of evidence in data…

Statistics Theory · Mathematics 2011-11-22 M. Grendar

Nurses should rely on the best evidence, but tend to struggle with statistics, impeding research integration into clinical practice. Statistical significance, a key concept in classical statistics, and its primary metric, the p-value, are…

Methodology · Statistics 2023-11-27 Christopher Holmberg

Since its introduction by Fisher, the method of hypothesis testing that relies on computing error probabilities has witnessed several developments. Perhaps the most significant development was the seminal contributions of Neyman and Pearson…

Other Statistics · Statistics 2026-05-08 Reason Machete

A key objective in conducting a Bell test is to quantify the statistical evidence against a local-hidden variable model (LHVM) given that we can collect only a finite number of trials in any experiment. The notion of statistical evidence is…

Quantum Physics · Physics 2018-04-19 David Elkouss , Stephanie Wehner

The Full Bayesian Significance Test (FBST) for precise hypotheses was presented by Pereira and Stern [Entropy 1(4) (1999) 99-110] as a Bayesian alternative instead of the traditional significance test using p-value. The FBST is based on the…

Methodology · Statistics 2019-06-12 Alejandra Estefanía Patiño Hoyos , Victor Fossaluza

The validity of classical hypothesis testing requires the significance level $\alpha$ be fixed before any statistical analysis takes place. This is a stringent requirement. For instance, it prohibits updating $\alpha$ during (or after) an…

Statistics Theory · Mathematics 2026-01-21 Ben Chugg , Tyron Lardy , Aaditya Ramdas , Peter Grünwald

Hypothesis testing is an essential statistical method in psychology and the cognitive sciences. The problems of traditional null hypothesis significance testing (NHST) have been discussed widely, and among the proposed solutions to the…

Methodology · Statistics 2020-05-28 Riko Kelter

We derive inferential procedures for large sample sizes that remain valid under data-dependent significance levels (so-called "post-hoc valid inference"). Classical statistical tools require that the significance level -- the "type-I error"…

Statistics Theory · Mathematics 2026-03-10 Ben Chugg , Etienne Gauthier , Michael I. Jordan , Aaditya Ramdas , Ian Waudby-Smith

Persistent homology is a vital tool for topological data analysis. Previous work has developed some statistical estimators for characteristics of collections of persistence diagrams. However, tools that provide statistical inference for…

Applications · Statistics 2016-02-23 Andrew Robinson , Katharine Turner

Particle physics experiments such as those run in the Large Hadron Collider result in huge quantities of data, which are boiled down to a few numbers from which it is hoped that a signal will be detected. We discuss a simple probability…

Applications · Statistics 2011-02-18 A. C. Davison , N. Sartori

Importance sampling is a common technique for Monte Carlo approximation, including Monte Carlo approximation of p-values. Here it is shown that a simple correction of the usual importance sampling p-values creates valid p-values, meaning…

Computation · Statistics 2011-04-12 Matthew T. Harrison

Null Hypothesis Significance Testing (NHST) has long been of central importance to psychology as a science, guiding theory development and underlying the application of evidence-based intervention and decision-making. Recent years, however,…

Methodology · Statistics 2020-10-20 Fintan Costello , Paul Watts

The internal validity of observational study is often subject to debate. In this study, we define the counterfactuals as the unobserved sample and intend to quantify its relationship with the null hypothesis statistical testing (NHST). We…

Applications · Statistics 2019-06-21 Tenglong Li , Kenneth A. Frank

In this paper, we demonstrate that a new measure of evidence we developed called the Dempster-Shafer p-value which allow for insights and interpretations which retain most of the structure of the p-value while covering for some of the…

Methodology · Statistics 2024-02-28 Kentaro Hoffman , Kai Zhang , Tyler McCormick , Jan Hannig

This article explains, and discusses the merits of, three approaches for analyzing the certainty with which statistical results can be extrapolated beyond the data gathered. Sometimes it may be possible to use more than one of these…

Methodology · Statistics 2016-10-03 Michael Wood