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In recent years, two parallel research trends have emerged in machine learning, yet their intersections remain largely unexplored. On one hand, there has been a significant increase in literature focused on Individual Treatment Effect (ITE)…

Causality defines the relationship between cause and effect. In multivariate time series field, this notion allows to characterize the links between several time series considering temporal lags. These phenomena are particularly important…

Methodology · Statistics 2023-06-01 Antonin Arsac , Aurore Lomet , Jean-Philippe Poli

An individualized treatment rule (ITR) is a decision rule that aims to improve individual patients health outcomes by recommending optimal treatments according to patients specific information. In observational studies, collected data may…

Methodology · Statistics 2023-10-03 Zeyu Bian , Erica EM Moodie , Susan M Shortreed , Sylvie D Lambert , Sahir Bhatnagar

Agentic AI systems combine LLM-based reasoning, orchestration, tool invocation, and interaction with external environments. These systems introduce faults that are difficult to characterize using existing taxonomies. To address this gap, we…

Software Engineering · Computer Science 2026-05-08 Mehil B Shah , Mohammad Mehdi Morovati , Mohammad Masudur Rahman , Foutse Khomh

The classical notion of causal effect identifiability is defined in terms of treatment and outcome variables. In this paper, we consider the identifiability of state-based causal effects: how an intervention on a particular state of…

Machine Learning · Computer Science 2026-02-24 Yizuo Chen , Adnan Darwiche

In this work, we consider causal inference in various high-dimensional treatment settings, including for single multi-valued treatments and vector treatments with binary or continuous components, when the number of treatments can be…

Statistics Theory · Mathematics 2026-02-26 Patrick Kramer , Edward H. Kennedy , Isaac M. Opper

Health informatics can inform decisions that practitioners, patients, policymakers, and researchers need to make about health and disease. Health informatics is built upon patient health data leading to the need to codify patient health…

Computers and Society · Computer Science 2023-04-14 Jacob S. Zelko , Sarah Gasman , Shenita R. Freeman , Dong Yun Lee , Jaan Altosaar , Azza Shoaibi , Gowtham Rao

Diseases involve complex processes and modifications to the cellular machinery. The gene expression profile of the affected cells contains characteristic patterns linked to a disease. Hence, biological knowledge pertaining to a disease can…

Quantitative Methods · Quantitative Biology 2020-04-13 Thomas Gaudelet , Noel Malod-Dognin , Jon Sanchez-Valle , Vera Pancaldi , Alfonso Valencia , Natasa Przulj

Machine Learning explainability techniques have been proposed as a means of `explaining' or interrogating a model in order to understand why a particular decision or prediction has been made. Such an ability is especially important at a…

Machine Learning · Statistics 2022-02-28 Matthew J. Vowels

I develop a new identification strategy for treatment effects when noisy measurements of unobserved confounding factors are available. I use proxy variables to construct a random variable conditional on which treatment variables become…

Econometrics · Economics 2022-09-30 Kenichi Nagasawa

Background: Symbolic models, particularly decision trees, are widely used in software engineering for explainable analytics in defect prediction, configuration tuning, and software quality assessment. Most of these models rely on…

Software Engineering · Computer Science 2026-02-19 Amirali Rayegan , Tim Menzies

Causal inference is essential for developing and evaluating medical interventions, yet real-world medical datasets are often difficult to access due to regulatory barriers. This makes synthetic data a potentially valuable asset that enables…

Machine Learning · Computer Science 2025-10-22 Harry Amad , Zhaozhi Qian , Dennis Frauen , Julianna Piskorz , Stefan Feuerriegel , Mihaela van der Schaar

Causal effects are commonly defined as comparisons of the potential outcomes under treatment and control, but this definition is threatened by the possibility that the treatment or control condition is not well-defined, existing instead in…

Methodology · Statistics 2019-04-26 Raiden B. Hasegawa , Sameer K. Deshpande , Dylan S. Small , Paul R. Rosenbaum

Structural Equation Models (SEM) are the standard approach to representing causal dependencies between variables in causal models. In this paper we propose a new interpretation of SEMs when reasoning about Actual Causality, in which SEMs…

Artificial Intelligence · Computer Science 2025-12-23 Maksim Gladyshev , Natasha Alechina , Mehdi Dastani , Dragan Doder , Brian Logan

Search engine logs have a great potential in tracking and predicting outbreaks of infectious disease. More precisely, one can use the search volume of some search terms to predict the infection rate of an infectious disease in nearly…

Machine Learning · Computer Science 2020-08-25 Thien Q. Tran , Jun Sakuma

This paper introduces a novel decomposition framework to explain heterogeneity in causal effects observed across different studies, considering both observational and randomized settings. We present a formal decomposition of between-study…

Methodology · Statistics 2025-12-18 Brian Gilbert , Ivan Dıaz , Kara E. Rudolph , Nicholas Williams , Tat-Thang Vo

Understanding causality should be a core requirement of any attempt to build real impact through AI. Due to the inherent unobservability of counterfactuals, large randomised trials (RCTs) are the standard for causal inference. But large…

Understanding the distinction between causation and correlation is critical in Alzheimer's disease (AD) research, as it impacts diagnosis, treatment, and the identification of true disease drivers. This experiment investigates the…

Artificial Intelligence · Computer Science 2025-06-13 Hamzah Dabool , Raghad Mustafa

Data scarcity is a tremendous challenge in causal effect estimation. In this paper, we propose to exploit additional data sources to facilitate estimating causal effects in the target population. Specifically, we leverage additional source…

Machine Learning · Computer Science 2021-06-01 Thanh Vinh Vo , Pengfei Wei , Trong Nghia Hoang , Tze-Yun Leong

Single-subject health data are becoming increasingly available thanks to advances in self-tracking technology (e.g., wearable devices, mobile apps, sensors, implants). Many users and health caregivers seek to use such observational time…

Applications · Statistics 2019-01-23 Eric Jay Daza
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