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Advances in high-throughput technologies have originated an ever-increasing availability of omics datasets. The integration of multiple heterogeneous data sources is currently an issue for biology and bioinformatics. Multiple kernel…

Machine Learning · Statistics 2024-12-04 Mitja Briscik , Gabriele Tazza , Marie-Agnes Dillies , László Vidács , Sébastien Dejean

Muilti-modality data are ubiquitous in biology, especially that we have entered the multi-omics era, when we can measure the same biological object (cell) from different aspects (omics) to provide a more comprehensive insight into the…

Genomics · Quantitative Biology 2021-12-15 Xuesong Wang , Zhihang Hu , Tingyang Yu , Ruijie Wang , Yumeng Wei , Juan Shu , Jianzhu Ma , Yu Li

Recent developments in single-cell omics technologies have enabled the quantification of molecular profiles in individual cells at an unparalleled resolution. Deep learning, a rapidly evolving sub-field of machine learning, has instilled a…

Genomics · Quantitative Biology 2024-01-17 Manoj M Wagle , Siqu Long , Carissa Chen , Chunlei Liu , Pengyi Yang

Multiple Instance Learning (MIL) has advanced WSI analysis but struggles with the complexity and heterogeneity of WSIs. Existing MIL methods face challenges in aggregating diverse patch information into robust WSI representations. While…

Computer Vision and Pattern Recognition · Computer Science 2025-07-28 Beidi Zhao , SangMook Kim , Hao Chen , Chen Zhou , Zu-hua Gao , Gang Wang , Xiaoxiao Li

Multimodal learning, integrating histology images and genomics, promises to enhance precision oncology with comprehensive views at microscopic and molecular levels. However, existing methods may not sufficiently model the shared or…

Computer Vision and Pattern Recognition · Computer Science 2024-06-12 Huahui Yi , Xiaofei Wang , Kang Li , Chao Li

In recent years, the advances in single-cell RNA-seq techniques have enabled us to perform large-scale transcriptomic profiling at single-cell resolution in a high-throughput manner. Unsupervised learning such as data clustering has become…

Genomics · Quantitative Biology 2020-01-07 Shixiong Zhang , Xiangtao Li , Qiuzhen Lin , Ka-Chun Wong

In this paper, we propose a novel multi-view clustering model, named Dual-space Co-training Large-scale Multi-view Clustering (DSCMC). The main objective of our approach is to enhance the clustering performance by leveraging co-training in…

Machine Learning · Computer Science 2024-01-30 Zisen Kong , Zhiqiang Fu , Dongxia Chang , Yiming Wang , Yao Zhao

Single-cell RNA sequencing (scRNA-seq) is essential for unraveling cellular heterogeneity and diversity, offering invaluable insights for bioinformatics advancements. Despite its potential, traditional clustering methods in scRNA-seq data…

Machine Learning · Computer Science 2025-10-01 Ping Xu , Zhiyuan Ning , Meng Xiao , Guihai Feng , Xin Li , Yuanchun Zhou , Pengfei Wang

We propose a novel method for multiple clustering that assumes a co-clustering structure (partitions in both rows and columns of the data matrix) in each view. The new method is applicable to high-dimensional data. It is based on a…

High-throughput molecular profiling technologies have produced high-dimensional multi-omics data, enabling systematic understanding of living systems at the genome scale. Studying molecular interactions across different data types helps…

Machine Learning · Computer Science 2020-10-23 Ehsan Hajiramezanali , Arman Hasanzadeh , Nick Duffield , Krishna R Narayanan , Xiaoning Qian

The Latent Block Model (LBM) is a prominent model-based co-clustering method, returning parametric representations of each block cluster and allowing the use of well-grounded model selection methods. The LBM, while adapted in literature to…

Multi-view clustering (MVC) is a popular technique for improving clustering performance using various data sources. However, existing methods primarily focus on acquiring consistent information while often neglecting the issue of redundancy…

Machine Learning · Computer Science 2023-09-26 Chenhang Cui , Yazhou Ren , Jingyu Pu , Jiawei Li , Xiaorong Pu , Tianyi Wu , Yutao Shi , Lifang He

Technological advances facilitate the ability to acquire multimodal data, posing a challenge for recognition systems while also providing an opportunity to use the heterogeneous nature of the information to increase the generalization…

Machine Learning · Computer Science 2024-08-06 Paweł Zyblewski , Leandro L. Minku

Image clustering is a particularly challenging computer vision task, which aims to generate annotations without human supervision. Recent advances focus on the use of self-supervised learning strategies in image clustering, by first…

Computer Vision and Pattern Recognition · Computer Science 2024-09-30 Foivos Ntelemis , Yaochu Jin , Spencer A. Thomas

Biclustering is an unsupervised machine-learning approach aiming to cluster rows and columns simultaneously in a data matrix. Several biclustering algorithms have been proposed for handling numeric datasets. However, real-world data mining…

Machine Learning · Computer Science 2024-08-26 Adán José-García , Julie Jacques , Clément Chauvet , Vincent Sobanski , Clarisse Dhaenens

Real data are often with multiple modalities or from multiple heterogeneous sources, thus forming so-called multi-view data, which receives more and more attentions in machine learning. Multi-view clustering (MVC) becomes its important…

Machine Learning · Computer Science 2019-03-05 Menglei Hu , Songcan Chen

Radiologists must utilize multiple modal images for tumor segmentation and diagnosis due to the limitations of medical imaging and the diversity of tumor signals. This leads to the development of multimodal learning in segmentation.…

Computer Vision and Pattern Recognition · Computer Science 2024-07-11 Chuyun Shen , Wenhao Li , Haoqing Chen , Xiaoling Wang , Fengping Zhu , Yuxin Li , Xiangfeng Wang , Bo Jin

Single-cell RNA sequencing (scRNA-seq) reveals cell heterogeneity, with cell clustering playing a key role in identifying cell types and marker genes. Recent advances, especially graph neural networks (GNNs)-based methods, have…

Genomics · Quantitative Biology 2025-10-03 Ping Xu , Zhiyuan Ning , Pengjiang Li , Wenhao Liu , Pengyang Wang , Jiaxu Cui , Yuanchun Zhou , Pengfei Wang

The swift advancement of single-cell RNA sequencing (scRNA-seq) technologies enables the investigation of cellular-level tissue heterogeneity. Cell annotation significantly contributes to the extensive downstream analysis of scRNA-seq data.…

Machine Learning · Computer Science 2024-11-28 Huifa Li , Jie Fu , Xinpeng Ling , Zhiyu Sun , Kuncan Wang , Zhili Chen

Multiple clustering aims at exploring alternative clusterings to organize the data into meaningful groups from different perspectives. Existing multiple clustering algorithms are designed for single-view data. We assume that the…

Machine Learning · Computer Science 2019-05-16 Shixing Yao , Guoxian Yu , Jun Wang , Carlotta Domeniconi , Xiangliang Zhang