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This paper presents a method of reconstruction a primary structure of a protein that folds into a given geometrical shape. This method predicts the primary structure of a protein and restores its linear sequence of amino acids in the…

Quantitative Methods · Quantitative Biology 2017-01-04 Andrii Riazanov , Mikhail Karasikov , Sergei Grudinin

Quantum annealing is a promising heuristic method to solve combinatorial optimization problems, and efforts to quantify performance on real-world problems provide insights into how this approach may be best used in practice. We investigate…

Quantum Physics · Physics 2023-09-07 Kazuki Ikeda , Yuma Nakamura , Travis S. Humble

Quantum annealing (QA) is a hardware-based heuristic optimization and sampling method applicable to discrete undirected graphical models. While similar to simulated annealing, QA relies on quantum, rather than thermal, effects to explore…

Quantum annealers offer an efficient way to compute high quality solutions of NP-hard problems when expressed in a QUBO (quadratic unconstrained binary optimization) or an Ising form. This is done by mapping a problem onto the physical…

Quantum Physics · Physics 2022-04-26 Elijah Pelofske , Georg Hahn , Hristo N. Djidjev

Ab initio wavefunction methods provide accurate molecular simulations but their computational scaling restricts applications to small systems. We develop a workflow combining quantum embedding to decompose a molecule into fragments with a…

We perform an in-depth comparison of quantum annealing with several classical optimisation techniques, namely thermal annealing, Nelder-Mead, and gradient descent. We begin with a direct study of the 2D Ising model on a quantum annealer,…

Quantum Physics · Physics 2022-10-19 Steve Abel , Andrew Blance , Michael Spannowsky

Providing an optimal path to a quantum annealing algorithm is key to finding good approximate solutions to computationally hard optimization problems. Reinforcement is one of the strategies that can be used to circumvent the exponentially…

Disordered Systems and Neural Networks · Physics 2022-07-27 Abolfazl Ramezanpour

Quantum annealers of D-Wave Systems, Inc., offer an efficient way to compute high quality solutions of NP-hard problems. This is done by mapping a problem onto the physical qubits of the quantum chip, from which a solution is obtained after…

Quantum Physics · Physics 2022-11-30 Elijah Pelofske , Georg Hahn , Hristo N. Djidjev

Variational quantum algorithms constitute one of the most widespread methods for using current noisy quantum computers. However, it is unknown if these heuristic algorithms provide any quantum-computational speedup, although we cannot…

Quantum annealers are specialized quantum computers for solving combinatorial optimization problems using special characteristics of quantum computing (QC), such as superposition, entanglement, and quantum tunneling. Theoretically, quantum…

Software Engineering · Computer Science 2024-07-29 Xinyi Wang , Asmar Muqeet , Tao Yue , Shaukat Ali , Paolo Arcaini

To increase efficiency in automotive manufacturing, newly produced vehicles can move autonomously from the production line to the distribution area. This requires an optimal placement of sensors to ensure full coverage while minimizing the…

Emerging Technologies · Computer Science 2025-07-23 Nico Kraus , Marvin Erdmann , Alexander Kuzmany , Daniel Porawski , Jonas Stein

Fitting geometric models onto outlier contaminated data is provably intractable. Many computer vision systems rely on random sampling heuristics to solve robust fitting, which do not provide optimality guarantees and error bounds. It is…

Computer Vision and Pattern Recognition · Computer Science 2022-06-28 Anh-Dzung Doan , Michele Sasdelli , David Suter , Tat-Jun Chin

A dilutely filled $N$-site optical lattice near zero temperature within a high-$Q$ multimode cavity can be mapped to a spin ensemble with tailorable interactions at all length scales. The effective full site to site interaction matrix can…

Quantum Physics · Physics 2017-03-15 Valentin Torggler , Sebastian Krämer , Helmut Ritsch

We explore the applicability of quantum annealing to the approximation task of curve fitting. To this end, we consider a function that shall approximate a given set of data points and is written as a finite linear combination of…

Optimization and Control · Mathematics 2026-02-27 Philipp Isserstedt , Daniel Jaroszewski , Wolfgang Mergenthaler , Felix Paul , Bastian Harrach

Quantum annealing is a promising method for solving combinational optimization problems and performing quantum chemical calculations. The main sources of errors in quantum annealing are the effects of decoherence and non-adiabatic…

Quantum Physics · Physics 2022-11-23 Takashi Imoto , Yuya Seki , Yuichiro Matsuzaki and , Shiro Kawabata

Quantum annealing and D-Wave quantum annealer attracted considerable attention for their ability to solve combinatorial optimization problems. In order to solve other type of optimization problems, it is necessary to apply certain kinds of…

Quantum Physics · Physics 2021-05-31 Michiya Kuramata , Ryota Katsuki , Kazuhide Nakata

From fundamental sciences to economics and industry, discrete optimization problems are ubiquitous. Yet, their complexity often renders exact solutions intractable, necessitating the use of approximate methods. Heuristics inspired by…

Quantum Physics · Physics 2025-11-20 Lorenzo Fioroni , Vincenzo Savona

Quantum annealing is typically regarded as a tool for combinatorial optimization, but its coherent dynamics also offer potential for machine learning. We present a model that encodes classical data into an Ising Hamiltonian, evolves it on a…

Data scarcity remains a central challenge in materials discovery, where finding meaningful descriptors and tuning models for generalization is critical but inherently a discrete optimization problem prone to multiple local minima…

We discuss recent theoretical developments in the study of simple lattice models of proteins. Such models are designed to understand general features of protein structures and mechanism of folding. Among the topics covered are (i) the use…

Soft Condensed Matter · Physics 2007-05-23 D. Thirumalai , D. K. Klimov