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Related papers: Folding lattice proteins with quantum annealing

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Quantum annealing aims at solving optimization problems efficiently by preparing the ground state of an Ising spin-Hamiltonian quantum mechanically. A prerequisite of building a quantum annealer is the implementation of programmable…

Quantum Gases · Physics 2020-11-10 Xingze Qiu , Peter Zoller , Xiaopeng Li

Quantum annealing is a computational paradigm in which optimisation problems are mapped onto the energy landscape of an interacting quantum system and explored through its dynamical evolution. By continuously transforming a simple initial…

Quantum Physics · Physics 2026-05-11 Steven Abel , Andrei Constantin , Luca A. Nutricati

Optimization problems associated with the interaction of linked particles are at the heart of polymer science, protein folding and other important problems in the physical sciences. In this review we explain how to recast these problems as…

The logistic network design is an abstract optimization problem that, under the assumption of minimal cost, seeks the optimal configuration of the supply chain's infrastructures and facilities based on customer demand. Key economic…

Quantum Physics · Physics 2021-02-04 Yongcheng Ding , Xi Chen , Lucas Lamata , Enrique Solano , Mikel Sanz

Quantum annealing offers a promising strategy for solving complex optimization problems by encoding the solution into the ground state of a problem Hamiltonian. While most implementations rely on spin-$1/2$ systems, we explore the…

Quantum Physics · Physics 2026-05-12 M. Haider Akbar , Özgür E. Müstecaplıoğlu

A phenomenological model hamiltonian to describe the folding of a protein with any given sequence is proposed. The protein is thought of as a collection of pieces of helices; as a consequence its configuration space increases with the…

Soft Condensed Matter · Physics 2009-10-30 Pierpaolo Bruscolini

We propose a framework to solve non-linear and history-dependent mechanical problems based on a hybrid classical computer -- quantum annealer approach. Quantum Computers are anticipated to solve particular operations exponentially faster.…

Computational Engineering, Finance, and Science · Computer Science 2024-02-20 Van-Dung Nguyen , Ling Wu , Françoise Remacle , Ludovic Noels

We propose a hybrid classical-quantum digitized-counterdiabatic algorithm to tackle the protein folding problem on a tetrahedral lattice. Digitized-counterdiabatic quantum computing is a paradigm developed to compress quantum algorithms via…

Quantum Physics · Physics 2023-07-13 Pranav Chandarana , Narendra N. Hegade , Iraitz Montalban , Enrique Solano , Xi Chen

In the post-Moore era, the need for efficient solutions to non-deterministic polynomial-time (NP) problems is becoming more pressing. In this context, the Ising model implemented by the probabilistic computing systems with probabilistic…

Applied Physics · Physics 2025-02-28 Chao Fang , Yihan He , Xiao Gong , Gengchiau Liang

The Fermi-Hubbard model (FHM) on a two dimensional square lattice has long been an important testbed and target for simulating fermionic Hamiltonians on quantum hardware. We present an alternative for quantum simulation of FHMs based on an…

Classical and quantum annealing is discussed for a kinetically constrained chain of $N$ non-interacting asymmetric double wells, represented by Ising spins in a longitudinal field $h$. It is shown that in certain cases, where the kinetic…

Statistical Mechanics · Physics 2016-08-31 Arnab Das , Bikas K. Chakrabarti , Robin B. Stinhcombe

Predicting protein secondary structure using lattice model is one of the most studied computational problem in bioinformatics. Here secondary structure or three dimensional structure of protein is predicted from its amino acid sequence.…

Computational Engineering, Finance, and Science · Computer Science 2014-07-18 Dipan Lal Shaw , M. Sohel Rahman , A. S. M. Sohidull Islam , Shuvasish Karmaker

Quantum annealing is a promising algorithm for solving combinatorial optimization problems. It searches for the ground state of the Ising model, which corresponds to the optimal solution of a given combinatorial optimization problem. The…

Statistical Mechanics · Physics 2026-02-25 Tomohiro Hattori , Shu Tanaka

Sampling equilibrium ensembles of dense polymer mixtures is a paradigmatically hard problem in computational physics, even in lattice-based models. Here, we develop a formalism based on interacting binary tensors that allows for tackling…

Soft Condensed Matter · Physics 2021-08-25 Cristian Micheletti , Philipp Hauke , Pietro Faccioli

Quantum annealing is a heuristic algorithm for searching the ground state of an Ising model. Heuristic algorithms aim to obtain near-optimal solutions with a reasonable computation time. Accordingly, many algorithms have so far been…

Quantum Physics · Physics 2022-11-09 Shuntaro Okada , Masayuki Ohzeki

Quantum annealing is a quantum algorithm to solve combinatorial optimization problems. In the current quantum annealing devices, the dynamic range of the input Ising Hamiltonian, defined as the ratio of the largest to the smallest…

Quantum Physics · Physics 2026-04-07 Kentaro Ohno , Nozomu Togawa

One of the main bottlenecks in solving combinatorial optimization problems with quantum annealers is the qubit connectivity in the hardware. A possible solution for larger connectivty is minor embedding. This techniques makes the…

Quantum Physics · Physics 2024-05-24 Michele Cattelan , Jemma Bennett , Sheir Yarkoni , Wolfgang Lechner

Protein folding -- the problem of predicting the spatial structure of a protein given its sequence of amino-acids -- has attracted considerable research effort in biochemistry in recent decades. In this work, we explore the potential of…

Quantum Physics · Physics 2022-04-06 Sami Boulebnane , Xavier Lucas , Agnes Meyder , Stanislaw Adaszewski , Ashley Montanaro

Quantum annealing is a quantum algorithm for computing solutions to combinatorial optimization problems. This study proposes a method for minor embedding optimization problems onto sparse quantum annealing hardware graphs called 4-clique…

Quantum Physics · Physics 2024-03-19 Elijah Pelofske

Quantum annealing is a novel type of analog computation that aims to use quantum mechanical fluctuations to search for optimal solutions of Ising problems. Quantum annealing in the Transverse Ising model, implemented on D-Wave QPUs, are…

Quantum Physics · Physics 2025-03-14 Elijah Pelofske