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We propose a computationally lean, two-stage approach that reliably predicts self-assembly behavior of complex charged molecules on a metallic surfaces under electrochemical conditions. Stage one uses ab initio simulations to provide…

Computational Physics · Physics 2020-07-15 Benedikt Hartl , Shubham Sharma , Oliver Brügner , Stijn F. L. Mertens , Michael Walter , Gerhard Kahl

The formation of biomolecular condensates inside cells often involve intrinsically disordered proteins (IDPs), and several of these IDPs are also capable of forming droplet-like dense assemblies on their own, through liquid-liquid phase…

Biological Physics · Physics 2020-02-26 Daniel Nilsson , Anders Irbäck

We study the percolation properties of the growing clusters model. In this model, a number of seeds placed on random locations on a lattice are allowed to grow with a constant velocity to form clusters. When two or more clusters eventually…

Statistical Mechanics · Physics 2015-05-18 Nikolaos Tsakiris , Michail Maragakis , Kosmas Kosmidis , Panos Argyrakis

Molecular search phenomena are observed in a variety of chemical and biological systems. During the search the participating particles frequently move in complex inhomogeneous environments with random transitions between different dynamic…

Statistical Mechanics · Physics 2018-11-13 Jaeoh Shin , Anatoly B. Kolomeisky

A general criterion for the existence of phase separation in driven one-dimensional systems is proposed. It is suggested that phase separation is related to the size dependence of the steady-state currents of domains in the system. A…

Statistical Mechanics · Physics 2009-11-07 Y. Kafri , E. Levine , D. Mukamel , G. M. Schutz , J. Torok

So-called polar liquid crystals possess spontaneous long-range mutual orientation of their electric dipole moments, conferring bulk polarity to fluid phases of matter. The combination of polarity and fluidity leads to complex phase…

Soft Condensed Matter · Physics 2025-08-22 Jordan Hobbs , Calum J. Gibb , Richard J. Mandle

We study the coarsening of strongly microphase separated membrane domains in the presence of recycling of material. We study the dynamics of the domain size distribution under both scale-free and size-dependent recycling. Closed form…

Subcellular Processes · Quantitative Biology 2018-05-11 S. Alex Rautu , G. Rowlands , M. S. Turner

Pattern formation inside a liquid phase is a phenomenon involved in many different aspects of life on our planet. The droplet form of a liquid that evaporates can reveal patterns that depend on the chemistry of the droplet and the physical…

Soft Condensed Matter · Physics 2024-09-12 Vahid Nasirimarekani

Cell membranes interact with a myriad of curvature-active proteins that control membrane morphology and are responsible for mechanosensation and mechanotransduction. Some of these proteins, such as those containing BAR domains, are curved…

Soft Condensed Matter · Physics 2020-09-21 Caterina Tozzi , Nikhil Walani , Anabel-Lise Le Roux , Pere Roca-Cusachs , Marino Arroyo

Biomembranes, which are mainly composed of neutral and charged lipids, exhibit a large variety of functional structures and dynamics. Here, we report a coarse-grained molecular dynamics (MD) simulation of the phase separation and…

Soft Condensed Matter · Physics 2016-11-07 Hiroaki Ito , Yuji Higuchi , Naofumi Shimokawa

Sorting is one of the fundamental problems in computer science. Playing a role in many processes, it has a lower complexity bound imposed by $\mathcal{O}(n\log{n})$ when executing on a sequential machine. This limit can be brought down to…

Hardware Architecture · Computer Science 2025-07-23 Daniel Bascones , Borja Morcillo

A chemostat enables long-term, continuous, exponential-phase growth in an environment limited as prescribed by the researcher. It is thus a potent tool for laboratory evolution - selecting for strains with desired phenotypes. However,…

Populations and Evolution · Quantitative Biology 2018-06-04 Aryeh Wides , Ron Milo

We present results from extensive 3-d molecular dynamics (MD) simulations of phase separation kinetics in fluids. A coarse-graining procedure is used to obtain state-of-the-art MD results. We observe an extended period of temporally linear…

Statistical Mechanics · Physics 2015-05-19 Shaista Ahmad , Subir K. Das , Sanjay Puri

The interaction of phase-separating systems with chemical reactions is of great interest in various contexts, from biology to material science. In biology, phase separation is thought to be the driving force behind the formation of…

Soft Condensed Matter · Physics 2026-01-08 Franco Blanchini , Elisa Franco , Giulia Giordano , Dino Osmanovic

In this paper the issue of filtering and smoothing in continuous discrete time is studied when the state variable evolves in some submanifold of Euclidean space, which may not have the usual Lebesgue measure. Formal expressions for…

Optimization and Control · Mathematics 2020-04-22 Filip Tronarp , Simo Särkkä

This work unravels the atomic details of the interaction of solute atoms with nanoscale crystalline defects. The complexity of this phenomenon is elucidated through detailed atom probe tomographic investigations on epitaxially-strained,…

Materials Science · Physics 2021-12-22 Samik Mukherjee , Simone Assali , Oussama Moutanabbir

Spatial gradients of diffusible signalling molecules play crucial roles in controlling diverse cellular behaviour such as cell differentiation, tissue patterning and chemotaxis. In this paper, we report the design and testing of a…

Quantitative Methods · Quantitative Biology 2016-12-15 Yasushi Saka , Murray MacPherson , Claudiu V. Giuraniuc

Biological cells use droplets to separate components and spatially control their interior. Experiments demonstrate that the complex, crowded cellular environment affects the droplet arrangement and their sizes. To understand this behavior,…

Soft Condensed Matter · Physics 2021-10-27 Estefania Vidal-Henriquez , David Zwicker

Spontaneous phase separation, or demixing, is important in biological phenomena such as cell sorting. In particle-based models, an open question is whether differences in diffusivity can drive such demixing. While…

Soft Condensed Matter · Physics 2023-07-10 Erin McCarthy , Ojan Damavandi , Raj Kumar Manna , M. Lisa Manning

Biological membranes are host to proteins and molecules which may form domain-like structures resulting in spatially-varying material properties. Vesicles with such heterogeneous membranes can exhibit intricate shapes at equilibrium and…

Soft Condensed Matter · Physics 2023-06-22 Prerna Gera , David Salac , Saverio E. Spagnolie