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Machine learning is widely used to analyze biological sequence data. Non-sequential models such as SVMs or feed-forward neural networks are often used although they have no natural way of handling sequences of varying length. Recurrent…

Quantitative Methods · Quantitative Biology 2016-03-14 Søren Kaae Sønderby , Casper Kaae Sønderby , Henrik Nielsen , Ole Winther

The design of DNN accelerators includes two key parts: HW resource configuration and mapping strategy. Intensive research has been conducted to optimize each of them independently. Unfortunately, optimizing for both together is extremely…

Neural and Evolutionary Computing · Computer Science 2022-01-28 Sheng-Chun Kao , Michael Pellauer , Angshuman Parashar , Tushar Krishna

Dynamic Random Access Memory (DRAM) is the de-facto choice for main memory devices due to its cost-effectiveness. It offers a larger capacity and higher bandwidth compared to SRAM but is slower than the latter. With each passing generation,…

Hardware Architecture · Computer Science 2022-01-19 Kaustav Goswami , Hemanta Kumar Mondal , Shirshendu Das , Dip Sankar Banerjee

Resistive random-access memory (RRAM) is widely recognized as a promising emerging hardware platform for deep neural networks (DNNs). Yet, due to manufacturing limitations, current RRAM devices are highly susceptible to hardware defects,…

Emerging Technologies · Computer Science 2024-04-25 Mingyuan Xiang , Xuhan Xie , Pedro Savarese , Xin Yuan , Michael Maire , Yanjing Li

Graph neural networks (GNNs) have gained significant interest for applications such as citation network analysis and drug discovery due to their ability to apply machine learning techniques on graph-structured data. GNNs typically employ a…

Hardware Architecture · Computer Science 2026-05-28 Siddhartha Raman Sundara Raman , Lizy John , Jaydeep P. Kulkarni

Processing-in-memory (PIM) architecture is an inherent match for data analytics application, but we observe major challenges to address when accelerating it using PIM. In this paper, we propose Darwin, a practical LRDIMM-based multi-level…

Systems and Control · Electrical Eng. & Systems 2025-09-23 Donghyuk Kim , Jae-Young Kim , Wontak Han , Jongsoon Won , Haerang Choi , Yongkee Kwon , Joo-Young Kim

Progress in artificial intelligence and machine learning over the past decade has been driven by the ability to train larger deep neural networks (DNNs), leading to a compute demand that far exceeds the growth in hardware performance…

Hardware Architecture · Computer Science 2023-08-07 Sourjya Roy , Cheng Wang , Anand Raghunathan

In this paper, we present GradPIM, a processing-in-memory architecture which accelerates parameter updates of deep neural networks training. As one of processing-in-memory techniques that could be realized in the near future, we propose an…

Machine Learning · Computer Science 2021-02-16 Heesu Kim , Hanmin Park , Taehyun Kim , Kwanheum Cho , Eojin Lee , Soojung Ryu , Hyuk-Jae Lee , Kiyoung Choi , Jinho Lee

Fast parallel search capabilities on large datasets provided by content addressable memories (CAM) are required across multiple application domains. However compared to RAM, CAMs feature high area overhead and power consumption, and as a…

Hardware Architecture · Computer Science 2023-12-27 Leonid Yavits

Servers produced by mainstream vendors are inefficient in processing Big Data queries due to bottlenecks inherent in the fundamental architecture of these systems. Current server blades contain multicore processors connected to DRAM memory…

Databases · Computer Science 2020-03-23 Ed T. Upchurch

This paper discusses recent research that aims to enable computation close to data, an approach we broadly call processing-in-memory (PIM). PIM places computation mechanisms in or near where the data is stored (i.e., inside memory chips or…

Hardware Architecture · Computer Science 2025-02-07 Onur Mutlu , Saugata Ghose , Juan Gómez-Luna , Rachata Ausavarungnirun , Mohammad Sadrosadati , Geraldo F. Oliveira

Open-access neuroimaging datasets have reached petabyte scale, and continue to grow. The ability to leverage the entirety of these datasets is limited to a restricted number of labs with both the capacity and infrastructure to process the…

Performance · Computer Science 2019-12-30 Valerie Hayot-Sasson , Shawn T Brown , Tristan Glatard

To support emerging applications ranging from holographic communications to extended reality, next-generation mobile wireless communication systems require ultra-fast and energy-efficient baseband processors. Traditional complementary…

Signal Processing · Electrical Eng. & Systems 2023-08-22 Qunsong Zeng , Jiawei Liu , Mingrui Jiang , Jun Lan , Yi Gong , Zhongrui Wang , Yida Li , Can Li , Jim Ignowski , Kaibin Huang

Designing lightweight convolutional neural network (CNN) models is an active research area in edge AI. Compute-in-memory (CIM) provides a new computing paradigm to alleviate time and energy consumption caused by data transfer in von Neumann…

Hardware Architecture · Computer Science 2025-08-19 Wenyong Zhou , Yuan Ren , Jiajun Zhou , Tianshu Hou , Ngai Wong

AI clusters today are one of the major uses of High Bandwidth Memory (HBM). However, HBM is suboptimal for AI workloads for several reasons. Analysis shows HBM is overprovisioned on write performance, but underprovisioned on density and…

Technologies for sequencing (reading) and synthesizing (writing) DNA have progressed on a Moore's law-like trajectory over the last three decades. This has motivated the idea of using DNA for data storage. Theoretically, DNA-based storage…

Emerging Technologies · Computer Science 2023-07-07 Ajay Manicka , Andrew Stephan , Sriram Chari , Gemma Mendonsa , Peyton Okubo , John Stolzberg-Schray , Anil Reddy , Marc Riedel

This work presents a method for reducing memory consumption to a constant complexity when training deep neural networks. The algorithm is based on the more biologically plausible alternatives of the backpropagation (BP): direct feedback…

Computer Vision and Pattern Recognition · Computer Science 2020-12-23 Tien Chu , Kamil Mykitiuk , Miron Szewczyk , Adam Wiktor , Zbigniew Wojna

As dynamic random access memory (DRAM) and other current transistor-based memories approach their scalability limits, the search for alternative storage methods becomes increasingly urgent. Phase-change memory (PCM) emerges as a promising…

Hardware Architecture · Computer Science 2025-11-10 Mahek Desai , Rowena Quinn , Marjan Asadinia

3D die-stacked DRAM has emerged as a key technology for delivering high bandwidth and high density for applications such as high-performance computing, graphics, and machine learning. However, different applications place diverse and…

Hardware Architecture · Computer Science 2025-12-16 Victor Cai , Jennifer Zhou , Haebin Do , David Brooks , Gu-Yeon Wei

Because of DNA appealing features as perfect material, including minuscule size, defined structural repeat and rigidity, programmable DNA-mediated processing is a promising computing paradigm, which employs DNAs as information storing and…

Biological Physics · Physics 2015-08-17 Jian-Jun Shu , Qi-Wen Wang , Kian-Yan Yong , Fangwei Shao , Kee Jin Lee
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