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As a sensitive functional imaging technique, positron emission tomography (PET) plays a critical role in early disease diagnosis. However, obtaining a high-quality PET image requires injecting a sufficient dose (standard dose) of…

Image and Video Processing · Electrical Eng. & Systems 2024-12-06 Caiwen Jiang , Mianxin Liu , Kaicong Sun , Dinggang Shen

Diffusion models (DMs) have recently been introduced as a regularizing prior for PET image reconstruction, integrating DMs trained on high-quality PET images with unsupervised schemes that condition on measured data. While these approaches…

Medical Physics · Physics 2026-03-18 George Webber , Alexander Hammers , Andrew P King , Andrew J Reader

We investigate subset-based optimization methods for positron emission tomography (PET) image reconstruction incorporating a regularizing prior. PET reconstruction methods that use a prior, such as the relative difference prior (RDP), are…

Medical Physics · Physics 2025-06-06 Matthias J. Ehrhardt , Zeljko Kereta , Georg Schramm

An approach to incorporate deep learning within an iterative image reconstruction framework to reconstruct images from severely incomplete measurement data is presented. Specifically, we utilize a convolutional neural network (CNN) as a…

Computer Vision and Pattern Recognition · Computer Science 2017-09-05 Brendan Kelly , Thomas P. Matthews , Mark A. Anastasio

Although sparse-view computed tomography (CT) has significantly reduced radiation dose, it also introduces severe artifacts which degrade the image quality. In recent years, deep learning-based methods for inverse problems have made…

Image and Video Processing · Electrical Eng. & Systems 2024-01-02 Shuo Xu , Yucheng Zhang , Gang Chen , Xincheng Xiang , Peng Cong , Yuewen Sun

Image deconvolution is the process of recovering convolutional degraded images, which is always a hard inverse problem because of its mathematically ill-posed property. On the success of the recently proposed deep image prior (DIP), we…

Computer Vision and Pattern Recognition · Computer Science 2022-11-28 Zhunxuan Wang , Zipei Wang , Qiqi Li , Hakan Bilen

Positron emission tomography (PET) scanners continue to increase sensitivity and axial coverage by adding an ever expanding array of block detectors. As they age, one or more block detectors may lose sensitivity due to a malfunction or…

Medical Physics · Physics 2019-10-17 William Whiteley , Jens Gregor

The analysis of multi-modality positron emission tomography and computed tomography (PET-CT) images for computer aided diagnosis applications requires combining the sensitivity of PET to detect abnormal regions with anatomical localization…

Computer Vision and Pattern Recognition · Computer Science 2019-10-29 Ashnil Kumar , Michael Fulham , Dagan Feng , Jinman Kim

Positron Emission Tomography (PET) is a functional imaging modality widely used in neuroscience studies. To obtain meaningful quantitative results from PET images, attenuation correction is necessary during image reconstruction. For PET/MR…

Medical Physics · Physics 2018-08-01 Kuang Gong , Jaewon Yang , Kyungsang Kim , Georges El Fakhri , Youngho Seo , Quanzheng Li

Deep image prior (DIP) proposed in recent research has revealed the inherent trait of convolutional neural networks (CNN) for capturing substantial low-level image statistics priors. This framework efficiently addresses the inverse problems…

Computer Vision and Pattern Recognition · Computer Science 2024-04-19 Ziyu Shu , Zhixin Pan

This paper investigates the application of unsupervised learning methods for computed tomography (CT) reconstruction. To motivate our work, we review several existing priors, namely the truncated Gaussian prior, the $l_1$ prior, the total…

Image and Video Processing · Electrical Eng. & Systems 2023-06-02 Chen Cheng , Qingping Zhou

Computed tomography (CT) involves a patient's exposure to ionizing radiation. To reduce the radiation dose, we can either lower the X-ray photon count or down-sample projection views. However, either of the ways often compromises image…

Image and Video Processing · Electrical Eng. & Systems 2023-10-12 Wenjun Xia , Yongyi Shi , Chuang Niu , Wenxiang Cong , Ge Wang

We present deformable unsupervised medical image registration using a randomly-initialized deep convolutional neural network (CNN) as regularization prior. Conventional registration methods predict a transformation by minimizing…

Image and Video Processing · Electrical Eng. & Systems 2019-08-05 Max-Heinrich Laves , Sontje Ihler , Tobias Ortmaier

Positron Emission Tomography (PET) scanners are usually designed with the goal to obtain the best compromise between sensitivity, resolution, field-of-view size, and cost. Therefore, it is difficult to improve the resolution of a PET…

Medical Physics · Physics 2023-07-18 Pablo Galve , Alejandro Lopez-Montes , Jose M Udias , Stephen C Moore , Joaquin L Herraiz

Uncompressed clinical data from modern positron emission tomography (PET) scanners are very large, exceeding 350 million data points (projection bins). The last decades have seen tremendous advancements in mathematical imaging tools many of…

Medical Physics · Physics 2020-01-08 Matthias J. Ehrhardt , Pawel Markiewicz , Carola-Bibiane Schönlieb

Radiation exposure in positron emission tomography (PET) imaging limits its usage in the studies of radiation-sensitive populations, e.g., pregnant women, children, and adults that require longitudinal imaging. Reducing the PET radiotracer…

Image and Video Processing · Electrical Eng. & Systems 2021-07-22 Viswanath P. Sudarshan , Uddeshya Upadhyay , Gary F. Egan , Zhaolin Chen , Suyash P. Awate

Medical imaging is playing a more and more important role in clinics. However, there are several issues in different imaging modalities such as slow imaging speed in MRI, radiation injury in CT and PET. Therefore, accelerating MRI, reducing…

Computer Vision and Pattern Recognition · Computer Science 2019-09-06 Jing Cheng , Haifeng Wang , Yanjie Zhu , Qiegen Liu , Qiyang Zhang , Ting Su , Jianwei Chen , Yongshuai Ge , Zhanli Hu , Xin Liu , Hairong Zheng , Leslie Ying , Dong Liang

A unified self-supervised and supervised deep learning framework for PET image reconstruction is presented, including deep-learned filtered backprojection (DL-FBP) for sinograms, deep-learned backproject then filter (DL-BPF) for…

Image and Video Processing · Electrical Eng. & Systems 2023-02-28 Andrew J. Reader

We develop and evaluate MlPET, a fast localized machine learning approach for probabilistic PET image analysis addressing the noise-resolution trade-off in conventional reconstructions. MlPET replaces computationally demanding Markov chain…

Medical Physics · Physics 2026-01-27 Thomas Mejer Hansen , Nana Christensen , Mikkel Vendelbo

Spectral computed tomography (CT) has attracted much attention in radiation dose reduction, metal artifacts removal, tissue quantification and material discrimination. The x-ray energy spectrum is divided into several bins, each…

Image and Video Processing · Electrical Eng. & Systems 2021-08-26 Weiwen Wu , Dianlin Hu , Chuang Niu , Lieza Vanden Broeke , Anthony P. H. Butler , Peng Cao , James Atlas , Alexander Chernoglazov , Varut Vardhanabhuti , Ge Wang