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The more we learn about the cytoplasm of cells, the more we realise that the cytoplasm is not uniform but instead is highly inhomogeneous. In any inhomogeneous solution, there are concentration gradients, and particles move either up or…

Subcellular Processes · Quantitative Biology 2019-04-03 Richard P. Sear

A ubiquitous way that cells share information is by exchanging molecules. Yet, the fundamental ways that this information exchange is influenced by intracellular dynamics remain unclear. Here we use information theory to investigate a…

Biological Physics · Physics 2020-07-23 Amir Erez , Tommy A. Byrd , Michael Vennettilli , Andrew Mugler

Coordinated responses to environmental stimuli are critical for multicellular organisms. To overcome the obstacles of cell-to-cell heterogeneity and noisy signaling dynamics within individual cells, cells must effectively exchange…

Biological Physics · Physics 2022-10-12 Guanyu Li , Ryan LeFebre , Alia Starman , Patrick Chappell , Andrew Mugler , Bo Sun

Diffusion-based and neural communication are two interesting domains in molecular communication. Both of them have distinct advantages and are exploited separately in many works. However, in some cases, neural and diffusion-based ways have…

Emerging Technologies · Computer Science 2015-07-07 Peng He , Yuming Mao , Qiang Liu , Kun Yang

Units of complex systems -- such as neurons in the brain or individuals in societies -- must communicate efficiently to function properly: e.g., allowing electrochemical signals to travel quickly among functionally connected neuronal areas…

Physics and Society · Physics 2020-03-17 Arsham Ghavasieh , Manlio De Domenico

Cells frequently employ extracellular vesicles, or exosomes, to signal across long distances and coordinate collective actions. Exosomes diffuse slowly, can be actively degraded, and contain stochastic amounts of molecular cargo. These…

Biological Physics · Physics 2025-10-15 Louis González , Andrew Mugler

In molecular communications, the direct detection of signaling molecules may be challenging due to a lack of suitable sensors and interference in the environment. Motivated by research in molecular biology, we investigate an indirect…

Information Theory · Computer Science 2022-04-25 Trang Ngoc Cao , Vahid Jamali , Wayan Wicke , Phee Lep Yeoh , Nikola Zlatanov , Jamie S Evans , Robert Schober

In this paper, we consider a molecular diffusion based communications link that conveys information on the macro-scale (several metres). The motivation is to apply molecular-based communications to challenging electromagnetic environments.…

Networking and Internet Architecture · Computer Science 2016-11-18 Siyi Wang , Weisi Guo , Song Qiu , Mark D. McDonnell

In the classical transport theory, the coefficients such as the diffusion, thermal conductivity and viscosity of fluid are usually expressed in a form proportional to the mean free path of molecules. We point out that this may cause a great…

Statistical Mechanics · Physics 2021-12-14 Xiaofeng Yang , Luyao Shang , Jian Sui

Flux of rigid or soft particles (such as drops, vesicles, red blood cells, etc.) in a channel is a complex function of particle concentration, which depends on the details of induced dissipation and suspension structure due to hydrodynamic…

Molecular communication (MC) is a kind of communication technology based on biochemical molecules for internet of bio-nano things, in which the biochemical molecule is used as the information carrier for the interconnection of nano-devices.…

Information Theory · Computer Science 2017-09-15 Jiaxing Wang , Bonan Yin , Mugen Peng

The biological cell exhibits a fantastic range of behaviors, but ultimately these are governed by a handful of physical and chemical principles. Here we explore simple theory, known for decades and based on the simple thermodynamics of…

Biomolecules · Quantitative Biology 2020-03-25 Daniel M. Zuckerman

We consider nanonodes randomly distributed in a circular area and characterize the received signal strength when a pair of these nodes employ molecular communication. Two communication methods are investigated, namely free diffusion and…

Emerging Technologies · Computer Science 2018-01-29 Rafay Iqbal Ansari , Chrysostomos Chrysostomou , Taqwa Saeed , Marios Lestas , Andreas Pitsillides

The motor part of a crawling eukaryotic cell can be represented schematically as an active continuum layer. The main active processes in this layer are protrusion, originating from non-equilibrium polymerization of actin fibers,…

Biological Physics · Physics 2015-01-29 Pierre Recho , Lev Truskinovsky

We study the effect of intracellular ion diffusion on ionic currents permeating through the cell membrane. Ion flux across the cell membrane is mediated by special proteins forming specific channels. The structure of potassium channels have…

Cell Behavior · Quantitative Biology 2015-02-20 D. Andreucci , D. Bellaveglia , E. N. M. Cirillo , S. Marconi

Bacterial cellulose biofilms are complex networks of strong interwoven nanofibers that control transport and protect bacterial colonies in the film. Design of diverse applications of bacterial cellulose films also relies on understanding…

Soft Condensed Matter · Physics 2022-06-09 Firoozeh Babayekhorasani , Maryam Hosseini , Patrick T. Spicer

This paper considers the scenario of a targeted drug delivery system, which consists of deploying a number of biological nanomachines close to a biological target (e.g. a tumor), able to deliver drug molecules in the diseased area. Suitably…

Emerging Technologies · Computer Science 2018-08-14 Mauro Femminella , Gianluca Reali , Athanasios V. Vasilakos

We consider the diffusion-advection problem in two simple cellular flow models (often invoked as examples for subdiffusive tracer's motion) and concentrate on the intermediate time range, in which the tracer's motion indeed may show…

Fluid Dynamics · Physics 2016-09-28 Patrick Pöschke , Igor M. Sokolov , Alexander A. Nepomnyashchy , Michael A. Zaks

Recent experiments have indicated that many biological systems self-organise near their critical point, which hints at a common design principle. While it has been suggested that information transmission is optimized near the critical…

Statistical Mechanics · Physics 2021-02-03 Matthijs Meijers , Sosuke Ito , Pieter Rein ten Wolde

Both action potentials and mechanosensitive signalling are an important communication mechanisms in plants. Considering an information theoretic framework, this paper explores the effective range of multiple action potentials for a long…

Molecular Networks · Quantitative Biology 2019-11-13 Hamdan Awan , Kareem Zeid , Raviraj S. Adve , Nigel Wallbridge , Carrol Plummer , Andrew W. Eckford
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