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Tensor canonical correlation analysis (TCCA) has garnered significant attention due to its effectiveness in capturing high-order correlations in multi-view learning. However, existing TCCA methods often underemphasize the characterization…

Optimization and Control · Mathematics 2025-12-10 Yanjiao Zhu , Wanquan Liu , Xianchao Xiu , Jianqin Sun

Single-cell multi-omics data contain huge information of cellular states, and analyzing these data can reveal valuable insights into cellular heterogeneity, diseases, and biological processes. However, as cell differentiation \& development…

Genomics · Quantitative Biology 2025-08-27 Wuchao Liu , Han Peng , Wengen Li , Yichao Zhang , Jihong Guan , Shuigeng Zhou

In brain-computer interface or neuroscience applications, generalized canonical correlation analysis (GCCA) is often used to extract correlated signal components in the neural activity of different subjects attending to the same stimulus.…

Signal Processing · Electrical Eng. & Systems 2023-02-17 Simon Geirnaert , Tom Francart , Alexander Bertrand

Despite the wealth of single-cell multi-omics data, it remains challenging to predict the consequences of novel genetic and chemical perturbations in the human body. It requires knowledge of molecular interactions at all biological levels,…

Artificial Intelligence · Computer Science 2025-01-22 You Wu , Lei Xie

Integrating multi-omics datasets through data-driven analysis offers a comprehensive understanding of the complex biological processes underlying various diseases, particularly cancer. Graph Neural Networks (GNNs) have recently demonstrated…

Machine Learning · Computer Science 2025-08-11 Jielong Lu , Zhihao Wu , Jiajun Yu , Jiajun Bu , Haishuai Wang

In classical canonical correlation analysis (CCA), the goal is to determine the linear transformations of two random vectors into two new random variables that are most strongly correlated. Canonical variables are pairs of these new random…

Methodology · Statistics 2025-10-24 Tomasz Górecki , Mirosław Krzyśko , Felix Gnettner , Piotr Kokoszka

Multi-omics data is increasingly being utilized to advance computational methods for cancer classification. However, multi-omics data integration poses significant challenges due to the high dimensionality, data complexity, and distinct…

Genomics · Quantitative Biology 2024-10-10 Fadi Alharbi , Aleksandar Vakanski , Boyu Zhang , Murtada K. Elbashir , Mohanad Mohammed

Coronary artery calcium (CAC) scoring plays a crucial role in the early detection and risk stratification of coronary artery disease (CAD). In this study, we focus on non-contrast coronary computed tomography angiography (CCTA) scans, which…

Extracting meaningful latent representations from high-dimensional sequential data is a crucial challenge in machine learning, with applications spanning natural science and engineering. We introduce InfoDPCCA, a dynamic probabilistic…

Machine Learning · Computer Science 2025-06-11 Shiqin Tang , Shujian Yu

We study the stochastic optimization of canonical correlation analysis (CCA), whose objective is nonconvex and does not decouple over training samples. Although several stochastic gradient based optimization algorithms have been recently…

Machine Learning · Computer Science 2016-11-15 Weiran Wang , Jialei Wang , Dan Garber , Nathan Srebro

Molecular subtyping of breast cancer is crucial for personalized treatment and prognosis. Traditional classification approaches rely on either histopathological images or gene expression profiling, limiting their predictive power. In this…

Computer Vision and Pattern Recognition · Computer Science 2025-03-05 Amin Honarmandi Shandiz

Sparse Canonical Correlation Analysis (SCCA) is a fundamental statistical tool for identifying linear relationships in high-dimensional, multi-view data. While minimax theory establishes an optimal sample complexity scaling additively with…

Signal Processing · Electrical Eng. & Systems 2026-04-21 Mengchu Xu , Jian Wang , Yonina C. Eldar

Anomalies are ubiquitous in all scientific fields and can express an unexpected event due to incomplete knowledge about the data distribution or an unknown process that suddenly comes into play and distorts observations. Due to such events'…

Computer Vision and Pattern Recognition · Computer Science 2021-12-14 Fabio Valerio Massoli , Fabrizio Falchi , Alperen Kantarci , Şeymanur Akti , Hazim Kemal Ekenel , Giuseppe Amato

Multiple types or views of data (e.g. genetics, proteomics) measured on the same set of individuals are now popularly generated in many biomedical studies. A particular interest might be the detection of sample subgroups (e.g. subtypes of…

Methodology · Statistics 2025-05-09 Kaifeng Yang , Thierry Chekouo , Sandra E. Safo

Deep Generative Models (DGMs) are versatile tools for learning data representations while adequately incorporating domain knowledge such as the specification of conditional probability distributions. Recently proposed DGMs tackle the…

Machine Learning · Computer Science 2024-01-30 Romain Lopez , Jan-Christian Huetter , Ehsan Hajiramezanali , Jonathan Pritchard , Aviv Regev

Existing approaches for unsupervised domain adaptive object detection perform feature alignment via adversarial training. While these methods achieve reasonable improvements in performance, they typically perform category-agnostic domain…

Computer Vision and Pattern Recognition · Computer Science 2021-04-06 Vibashan VS , Vikram Gupta , Poojan Oza , Vishwanath A. Sindagi , Vishal M. Patel

We extend multi-way, multivariate ANOVA-type analysis to cases where one covariate is the view, with features of each view coming from different, high-dimensional domains. The different views are assumed to be connected by having paired…

Machine Learning · Statistics 2009-12-17 Ilkka Huopaniemi , Tommi Suvitaival , Janne Nikkilä , Matej Orešič , Samuel Kaski

Gene set analysis (GSA) is a foundational approach for interpreting genomic data of diseases by linking genes to biological processes. However, conventional GSA methods overlook clinical context of the analyses, often generating long lists…

Knowledge of molecular subtypes of gliomas can provide valuable information for tailored therapies. This study aimed to investigate the use of deep convolutional neural networks (DCNNs) for noninvasive glioma subtyping with radiological…

Image and Video Processing · Electrical Eng. & Systems 2022-03-14 Dong Wei , Yiming Li , Yinyan Wang , Tianyi Qian , Yefeng Zheng

In this paper we address the problem of matching sets of vectors embedded in the same input space. We propose an approach which is motivated by canonical correlation analysis (CCA), a statistical technique which has proven successful in a…

Computer Vision and Pattern Recognition · Computer Science 2013-06-11 Ognjen Arandjelovic