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In vivo and in vitro cells rely on the support of an underlying biocompatible substrate, such as the extracellular matrix or a culture substrate, to spread and proliferate. The mechanical and chemical properties of such structures play a…

Soft Condensed Matter · Physics 2021-11-04 Diogo E. P. Pinto , Margarida M. Telo da Gama , Nuno A. M. Araujo

A curious feature of organ and organoid morphogenesis is that in certain cases, spatial oscillations in the thickness of the growing "film" are out-of-phase with the deformation of the slower-growing "substrate," while in other cases, the…

Biological Physics · Physics 2018-12-26 T. A. Engstrom , Teng Zhang , A. K. Lawton , A. L. Joyner , J. M. Schwarz

There is a growing interest in cell-type-specific analysis from bulk samples with a mixture of different cell types. A critical first step in such analyses is the accurate estimation of cell-type proportions in a bulk sample. Although many…

Methodology · Statistics 2022-09-12 Biao Cai , Jingfei Zhang , Hongyu Li , Chang Su , Hongyu Zhao

Topological invariants are a significant ingredient in the study of topological phases of matter that intertwines the supposedly contradicting concepts of bulk and boundary. The nature of the invariants differ depending on the dimension of…

Mesoscale and Nanoscale Physics · Physics 2023-11-28 Srijata Lahiri , Saurabh Basu

We investigate elastic periodic structures characterized by topologically nontrivial bandgaps supporting backscattering suppressed edge waves. These edge waves are topologically protected and are obtained by breaking inversion symmetry…

Soft Condensed Matter · Physics 2017-03-08 Raj Kumar Pal , Massimo Ruzzene

In order to describe two-dimensionally packed cells in epithelial tissues both mathematically and physically, there have been developed several sorts of geometrical models, such as the vertex model, the finite element model, the…

Biological Physics · Physics 2014-11-19 Yukitaka Ishimoto , Yoshihiro Morishita

Many living and physical systems such as cell aggregates, tissues or bacterial colonies behave as unconventional systems of particles that are strongly constrained by volume exclusion and shape interactions. Understanding how these…

Quantitative Methods · Quantitative Biology 2026-05-20 Antoine Diez , Jean Feydy

Bending the edge of a thin elastic material promotes rigidity far from its clamped boundary. However, this curvature-induced rigidity can be overwhelmed by gravity or other external loading, resulting in elastic buckling and large…

Soft Condensed Matter · Physics 2025-04-16 Hanzhang Mao , Thomas G. J. Chandler , Mark Han , Saverio E. Spagnolie

A three-dimensional X-ray tomography is performed to investigate the internal structure and its evolution of a crumpled aluminum foil. The upper and lower bounds of the internal geometric fractal dimension are determined, which increase…

Soft Condensed Matter · Physics 2009-12-18 Yen-Chih Lin , J. M. Sun , H. W. Yang , C. L. Wang , Yeukuang Hwu , T. M. Hong

Critical systems are described by conformal field theories, whose dynamics can be exactly solved in two dimensions. In the presence of a boundary, with the so-called method of images it is possible to study the surface critical behaviour of…

High Energy Physics - Theory · Physics 2007-05-23 Valentina Riva

The phenomenological model for cell shape deformation and cell migration (Chen et.al. 2018; Vermolen and Gefen 2012) is extended with the incorporation of cell traction forces and the evolution of cell equilibrium shapes as a result of cell…

Cell Behavior · Quantitative Biology 2021-04-27 Qiyao Peng , Fred Vermolen , Daphne Weihs

Starting from the hypothesis that both physics, in particular space-time and the physical vacuum, and the corresponding mathematics are discrete on the Planck scale we develop a certain framework in form of a class of ' cellular networks'…

High Energy Physics - Theory · Physics 2016-09-06 Manfred Requardt

This monograph offers an overview on the topological invariants in fermionic topological insulators from the complex classes. Tools from K-theory and non-commutative geometry are used to define bulk and boundary invariants, to establish the…

Mathematical Physics · Physics 2016-02-17 Emil Prodan , Hermann Schulz-Baldes

We present a theoretical and computational model for the behavior of a porous solid undergoing two interdependent processes, the finite deformation of a solid and species migration through the solid, which are distinct in bulk and on…

Soft Condensed Matter · Physics 2023-05-16 Jaemin Kim , Ida Ang , Francesco Ballarin , Chung-Yuen Hui , Nikolaos Bouklas

We study the topological properties of the two-body bound states in an interacting Haldane model as a function of interparticle interactions. In particular, we identify topological phases where the two-body edge states have either the same…

Quantum Gases · Physics 2018-02-01 Grazia Salerno , Marco Di Liberto , Chiara Menotti , Iacopo Carusotto

Quantum Hall systems are characterized by the quantization of the Hall conductance -- a bulk property rooted in the topological structure of the underlying quantum states. In condensed matter devices, material imperfections hinder a direct…

Cells are dynamic systems characterized by temporal variations in biophysical properties such as stiffness and contractility. Recent studies show that the recruitment and release of actin filaments into and out of the cell cortex - a…

Biological Physics · Physics 2023-02-13 Garrett Zills , Trinanjan Datta , Abdul N Malmi-Kakkada

We introduce a general theoretical framework to study the shape dynamics of actively growing and remodeling surfaces. Using this framework we develop a physical model for growing bacterial cell walls and study the interplay of cell shape…

Biological Physics · Physics 2016-04-08 Shiladitya Banerjee , Norbert F. Scherer , Aaron R. Dinner

In this paper we study the structure of cellular pseudomanifolds (aka abstract polytopes). These are natural combinatorial generalisations of polytopal spheres (i.e., boundary complexes of convex polytopes). This class is closed under…

Combinatorics · Mathematics 2023-07-06 Bhaskar Bagchi , Basudeb Datta

The bulk-edge correspondence (BEC) is the hallmark of topological systems. In continuous (nonlattice) Hermitian systems with an unbounded wave vector, it was recently shown that the BEC of Chern insulators is modified. How would it be…

Mesoscale and Nanoscale Physics · Physics 2023-02-13 Orr Rapoport , Moshe Goldstein