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Recent advances in deep learning for medical image segmentation demonstrate expert-level accuracy. However, in clinically realistic environments, such methods have marginal performance due to differences in image domains, including…

Computer Vision and Pattern Recognition · Computer Science 2019-06-13 Ling Zhang , Xiaosong Wang , Dong Yang , Thomas Sanford , Stephanie Harmon , Baris Turkbey , Holger Roth , Andriy Myronenko , Daguang Xu , Ziyue Xu

We propose DiRL, a Diversity-inducing Representation Learning technique for histopathology imaging. Self-supervised learning techniques, such as contrastive and non-contrastive approaches, have been shown to learn rich and effective…

Computer Vision and Pattern Recognition · Computer Science 2023-09-13 Saarthak Kapse , Srijan Das , Jingwei Zhang , Rajarsi R. Gupta , Joel Saltz , Dimitris Samaras , Prateek Prasanna

Whole slide images (WSI) are microscopy images of stained tissue slides routinely prepared for diagnosis and treatment selection in medical practice. WSI are very large (gigapixel size) and complex (made of up to millions of cells). The…

Computer Vision and Pattern Recognition · Computer Science 2022-12-08 Tristan Lazard , Marvin Lerousseau , Etienne Decencière , Thomas Walter

Domain adaptation (DA) techniques have the potential in machine learning to alleviate distribution differences between training and test sets by leveraging information from source domains. In image classification, most advances in DA have…

Computer Vision and Pattern Recognition · Computer Science 2025-08-29 Ahmad Chaddad , Yihang Wu , Reem Kateb , Christian Desrosiers

Digital pathology has attracted significant attention in recent years. Analysis of Whole Slide Images (WSIs) is challenging because they are very large, i.e., of Giga-pixel resolution. Identifying Regions of Interest (ROIs) is the first…

Image and Video Processing · Electrical Eng. & Systems 2020-09-21 A Nugaliyadde , Kok Wai Wong , Jeremy Parry , Ferdous Sohel , Hamid Laga , Upeka V. Somaratne , Chris Yeomans , Orchid Foster

Accurate analysis of histopathological images is critical for disease diagnosis and treatment planning. Whole-slide images (WSIs), which digitize tissue specimens at gigapixel resolution, are fundamental to this process but require…

Computer Vision and Pattern Recognition · Computer Science 2026-05-07 Enhui Chai , Sicheng Chen , Tianyi Zhang , Chad Wong , Kecheng Huang , Zeyu Liu , Fei Xia

Traditional domain generalization methods often rely on domain alignment to reduce inter-domain distribution differences and learn domain-invariant representations. However, domain shifts are inherently difficult to eliminate, which limits…

Computer Vision and Pattern Recognition · Computer Science 2024-12-10 Yuheng Xu , Taiping Zhang

Accurate classification of Whole Slide Images (WSIs) and Regions of Interest (ROIs) is a fundamental challenge in computational pathology. While mainstream approaches often adopt Multiple Instance Learning (MIL), they struggle to capture…

Computer Vision and Pattern Recognition · Computer Science 2025-08-08 Mingxi Fu , Xitong Ling , Yuxuan Chen , Jiawen Li , fanglei fu , Huaitian Yuan , Tian Guan , Yonghong He , Lianghui Zhu

In this paper, we propose a novel interpretation method tailored to histological Whole Slide Image (WSI) processing. A Deep Neural Network (DNN), inspired by Bag-of-Features models is equipped with a Multiple Instance Learning (MIL) branch…

Computer Vision and Pattern Recognition · Computer Science 2019-04-17 Magdalini Paschali , Muhammad Ferjad Naeem , Walter Simson , Katja Steiger , Martin Mollenhauer , Nassir Navab

Digital whole slides images contain an enormous amount of information providing a strong motivation for the development of automated image analysis tools. Particularly deep neural networks show high potential with respect to various tasks…

Computer Vision and Pattern Recognition · Computer Science 2023-12-07 Michael Gadermayr , Maximilian Tschuchnig

Whole Slide Images (WSI), obtained by high-resolution digital scanning of microscope slides at multiple scales, are the cornerstone of modern Digital Pathology. However, they represent a particular challenge to AI-based/AI-mediated analysis…

Computer Vision and Pattern Recognition · Computer Science 2024-04-12 Martim Afonso , Praphulla M. S. Bhawsar , Monjoy Saha , Jonas S. Almeida , Arlindo L. Oliveira

Convolutional Neural Networks (CNNs) can play a key role in Medical Image Analysis under large-scale annotated datasets. However, preparing such massive dataset is demanding. In this context, Generative Adversarial Networks (GANs) can…

Image and Video Processing · Electrical Eng. & Systems 2021-06-04 Changhee Han

The segmentation of prostate whole gland and transition zone in Diffusion Weighted MRI (DWI) are the first step in designing computer-aided detection algorithms for prostate cancer. However, variations in MRI acquisition parameters and…

Image and Video Processing · Electrical Eng. & Systems 2020-10-29 Saman Motamed , Isha Gujrathi , Dominik Deniffel , Anton Oentoro , Masoom A. Haider , Farzad Khalvati

We present a novel weakly-supervised framework for classifying whole slide images (WSIs). WSIs, due to their gigapixel resolution, are commonly processed by patch-wise classification with patch-level labels. However, patch-level labels…

Computer Vision and Pattern Recognition · Computer Science 2022-03-10 Tiange Xiang , Yang Song , Chaoyi Zhang , Dongnan Liu , Mei Chen , Fan Zhang , Heng Huang , Lauren O'Donnell , Weidong Cai

In histopathology, scanner-induced domain shifts are known to impede the performance of trained neural networks when tested on unseen data. Multi-domain pre-training or dedicated domain-generalization techniques can help to develop…

Digital pathology has made significant advances in tumor diagnosis and segmentation, but image variability due to differences in organs, tissue preparation, and acquisition - known as domain shift - limits the effectiveness of current…

Image and Video Processing · Electrical Eng. & Systems 2024-09-23 Ho Heon Kim , Won Chan Jeong , Young Shin Ko , Young Jin Park

Robustness and generalizability in medical image segmentation are often hindered by scarcity and limited diversity of training data, which stands in contrast to the variability encountered during inference. While conventional strategies --…

Computer Vision and Pattern Recognition · Computer Science 2024-12-18 Yimu Pan , Sitao Zhang , Alison D. Gernand , Jeffery A. Goldstein , James Z. Wang

Assessing microsatellite stability status of a patient's colorectal cancer is crucial in personalizing treatment regime. Recently, convolutional-neural-networks (CNN) combined with transfer-learning approaches were proposed to circumvent…

Computer Vision and Pattern Recognition · Computer Science 2022-08-23 Daniel Shats , Hadar Hezi , Guy Shani , Yosef E. Maruvka , Moti Freiman

Advancement in digital pathology and artificial intelligence has enabled deep learning-based computer vision techniques for automated disease diagnosis and prognosis. However, WSIs present unique computational and algorithmic challenges.…

Computer Vision and Pattern Recognition · Computer Science 2021-06-15 Yash Sharma , Lubaina Ehsan , Sana Syed , Donald E. Brown

End-to-end deep learning improves breast cancer classification on diffusion-weighted MR images (DWI) using a convolutional neural network (CNN) architecture. A limitation of CNN as opposed to previous model-based approaches is the…