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Computational pathology is a domain that aims to develop algorithms to automatically analyze large digitized histopathology images, called whole slide images (WSI). WSIs are produced scanning thin tissue samples that are stained to make…
The domain generalization problem has been widely investigated in deep learning for non-contrast imaging over the last years, but it received limited attention for contrast-enhanced imaging. However, there are marked differences in contrast…
Histopathological analysis of Whole Slide Images (WSIs) has seen a surge in the utilization of deep learning methods, particularly Convolutional Neural Networks (CNNs). However, CNNs often fall short in capturing the intricate spatial…
Digital whole slide images (WSIs) are generally captured at microscopic resolution and encompass extensive spatial data. Directly feeding these images to deep learning models is computationally intractable due to memory constraints, while…
Convolutional Neural Networks (CNN) are state-of-the-art models for many image classification tasks. However, to recognize cancer subtypes automatically, training a CNN on gigapixel resolution Whole Slide Tissue Images (WSI) is currently…
The rapid growth of digital pathology in recent years has provided an ideal opportunity for the development of artificial intelligence-based tools to improve the accuracy and efficiency of clinical diagnoses. One of the significant…
The development of computational pathology lies in the consensus that pathological characteristics of tumors are significant guidance for cancer diagnostics. Most existing research focuses on the inner-contextual information within each WSI…
We propose an exhaustive methodology that leverages all levels of feature abstraction, targeting an enhancement in the generalizability of image classification to unobserved hospitals. Our approach incorporates augmentation-based…
Generalization capability to unseen domains is crucial for machine learning models when deploying to real-world conditions. We investigate the challenging problem of domain generalization, i.e., training a model on multi-domain source data…
Deep neural networks are increasingly applied in automated histopathology. Yet, whole-slide images (WSIs) are often acquired at gigapixel sizes, rendering them computationally infeasible to analyze entirely at high resolution. Diagnostic…
In modern cancer diagnostics, Whole Slide Imaging (WSI) is widely used to digitize tissue specimens for detailed, high-resolution examination; however, other diagnostic approaches, such as liquid biopsy and molecular testing, are also…
Considering the profound transformation affecting pathology practice, we aimed to develop a scalable artificial intelligence (AI) system to diagnose colorectal cancer from whole-slide images (WSI). For this, we propose a deep learning (DL)…
With the development of computer-aided diagnosis (CAD) and image scanning technology, Whole-slide Image (WSI) scanners are widely used in the field of pathological diagnosis. Therefore, WSI analysis has become the key to modern digital…
The insertion of deep learning in medical image analysis had lead to the development of state-of-the art strategies in several applications such a disease classification, as well as abnormality detection and segmentation. However, even the…
Domain shift is a critical problem for pathology AI as pathology data is heavily influenced by center-specific conditions. Current pathology domain adaptation methods focus on image patches rather than WSI, thus failing to capture global…
Deep learning models that are trained on histopathological images obtained from a single lab and/or scanner give poor inference performance on images obtained from another scanner/lab with a different staining protocol. In recent years,…
Medical image segmentation plays a crucial role in clinical workflows, but domain shift often leads to performance degradation when models are applied to unseen clinical domains. This challenge arises due to variations in imaging…
Histopathological whole slide images (WSIs) classification has become a foundation task in medical microscopic imaging processing. Prevailing approaches involve learning WSIs as instance-bag representations, emphasizing significant…
In computer vision, data shift has proven to be a major barrier for safe and robust deep learning applications. In medical applications, histopathological images are often associated with data shift and they are hardly available. It is…
Supervised deep learning methods have achieved considerable success in medical image analysis, owing to the availability of large-scale and well-annotated datasets. However, creating such datasets for whole slide images (WSIs) in…