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The Quantum Approximate Optimization Algorithm (QAOA) is a variational quantum algorithm that can be used to approximately solve combinatorial optimization problems. However, a major limitation of QAOA is that it is a "local" algorithm for…

Quantum Physics · Physics 2025-04-10 Quinn Langfitt , Reuben Tate , Stephan Eidenbenz

A frequent starting point of quantum computation platforms are two-state quantum systems, i.e., qubits. However, in the context of integer optimization problems, relevant to scheduling optimization and operations research, it is often more…

This research explores the integration of the Quantum Approximate Optimization Algorithm (QAOA) into Hybrid Quantum-HPC systems for solving the Max-Cut problem, comparing its performance with classical algorithms like brute-force search and…

Quantum Physics · Physics 2024-10-22 Ishan Patwardhan , Akhil Akkapelli

The Quantum Approximate Optimisation Algorithm (QAOA) is a widely studied quantum-classical iterative heuristic for combinatorial optimisation. While QAOA targets problems in complexity class NP, the classical optimisation procedure…

Quantum Physics · Physics 2025-11-12 Tom Krüger , Wolfgang Mauerer

Parameterized quantum circuits are attractive candidates for potential quantum advantage in the near term and beyond. At the same time, as quantum computing hardware not only continues to improve but also begins to incorporate new features…

Quantum Physics · Physics 2024-03-19 Tobias Stollenwerk , Stuart Hadfield

The Quantum Approximate Optimization Algorithm (QAOA) requires that circuit parameters are determined that allow one to sample from high-quality solutions to combinatorial optimization problems. Such parameters can be obtained using either…

Quantum Physics · Physics 2023-01-11 David Headley , Frank K. Wilhelm

One of the leading candidates for near-term quantum advantage is the class of Variational Quantum Algorithms, but these algorithms suffer from classical difficulty in optimizing the variational parameters as the number of parameters…

Quantum Physics · Physics 2022-11-28 Cem M. Unsal , Lucas T. Brady

In order to qualify quantum algorithms for industrial NP-Hard problems, comparing them to available polynomial approximate classical algorithms and not only to exact ones -- exponential by nature -- , is necessary. This is a great challenge…

The Quantum Approximate Optimization Algorithm can naturally be applied to combinatorial search problems on graphs. The quantum circuit has p applications of a unitary operator that respects the locality of the graph. On a graph with…

Quantum Physics · Physics 2020-04-21 Edward Farhi , David Gamarnik , Sam Gutmann

A protein is a linear chain containing a set of amino acids, which folds on itself to create a specific native structure, also called the minimum energy conformation. It is the native structure that determines the functionality of each…

Biomolecules · Quantitative Biology 2021-05-28 Nabil Boumedine , Sadek Bouroubi

We investigate the potential of the Quantum Approximate Optimization Algorithm (QAOA) for reducing energy consumption in route planning, a key challenge in logistics due to the NP-hard nature of the Traveling Salesman and Vehicle Routing…

Emerging Technologies · Computer Science 2026-04-21 Ayush Nadiger , Adriana Caraeni , Katie Schouten

This paper proposes a quasi-binary encoding based algorithm for solving a specific quadratic optimization models with discrete variables, in the quantum approximate optimization algorithm (QAOA) framework. The quadratic optimization model…

Quantum Physics · Physics 2024-01-25 Bingren Chen , Hanqing Wu , Haomu Yuan , Lei Wu , Xin Li

A new methodology is proposed to solve classical Boolean problems as Hamiltonians, using the quantum approximate optimization algorithm (QAOA). Our methodology successfully finds all optimized approximated solutions for Boolean problems,…

Quantum Physics · Physics 2024-07-11 Ali Al-Bayaty , Marek Perkowski

We explore strategies aimed at reducing the amount of computation, both quantum and classical, required to run the Quantum Approximate Optimization Algorithm (QAOA). First, following Wurtz et al. [Phys.Rev A 104:052419], we consider the…

The Quantum Approximate Optimization Algorithm (QAOA) is a prominent quantum algorithm designed to find approximate solutions to combinatorial optimization problems, which are challenging for classical computers. In the current era, where…

The quantum approximate optimization algorithm (QAOA) applies two Hamiltonians to a quantum system in alternation. The original goal of the algorithm was to drive the system close to the ground state of one of the Hamiltonians. This paper…

Quantum Physics · Physics 2018-12-31 Seth Lloyd

Conformation generation, also known as molecular unfolding (MU), is a crucial step in structure-based drug design, remaining a challenging combinatorial optimization problem. Quantum annealing (QA) has shown great potential for solving…

Usage of cutting-edge artificial intelligence will be the baseline at future high energy colliders such as the High Luminosity Large Hadron Collider, to cope with the enormously increasing demand of the computing resources. The rapid…

Quantum Physics · Physics 2024-03-01 Hideki Okawa

Quantum Approximate Optimization Algorithm (QAOA) and Quantum Annealing are prominent approaches for solving combinatorial optimization problems, such as those formulated as Quadratic Unconstrained Binary Optimization (QUBO). These…

The quantum approximate optimization algorithm~(QAOA) first proposed by Farhi et al. promises near-term applications based on its simplicity, universality, and provable optimality. A depth-p QAOA consists of p interleaved unitary…

Quantum Physics · Physics 2019-05-30 Murphy Yuezhen Niu , Sirui Lu , Isaac L. Chuang